“…Immunofluorescent (IF) studies of serum specimens of patients with car cinoma of the prostate (CaP) have disclosed the presence in some of these patients of anti-: nuclear [4][5][6], bile canalicular [5], and epithelial [1,2,4,6] antibodies. Initially, the antiepithelial antibodies were observed to react with the cytoplasmic membrane (CM) of prostatic secretory epithelial cells [6], However, recently completed studies directed at attempting to elucidate the possible tissue -and species -specificity of these antibodies disclosed that A b u n Demonstration of Intercellular and Basement-Membrane some of the patients with CaP possessing CM antibodies to prostatic epi thelial tissue also contained antibodies reactive with components of strati fied squamous epithelium, e.g., intercellular (IC) areas and keratohyalin gran ules (?)…”