Prospective Study on Stereotactic Radiotherapy of Limited Stage Non-Small Cell Lung Cancer

Høyer, Morten; Roed, Henrik; Hansen, Aviaja Anna; Ohlhuis, Lars; Jorgen, P.; Nellemann, Hanne; Berthelsen, Anne Kiil; Grau, C.; Engelholm, Svend A.; Maase, Hans von der

doi:10.1016/j.ijrobp.2005.07.675

Cited by 23 publications

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“…In SBRT, hypodense regions of the liver occurring 1 Á3 months after treatment in volumes receiving 30 Gy in 3 fractions [25] or 14 Gy in 1 fraction [27] might be an indication of hepatic hypofunction. In SBRT of lung tumors, studies suggest that pneumonitis and lung fibrosis may be limited if small tumors are treated with central doses of 45 Á67 Gy in 3 fractions [7,8,28].…”

Section: Discussionmentioning

confidence: 99%

“…A detailed description of the principles of treatment has been given previously [6,7,9]. Patients were firmly immobilized by custom made fixation systems that differed between the centres in Aarhus and Copenhagen.…”

Section: Radiotherapymentioning

confidence: 99%

“…Patients were firmly immobilized by custom made fixation systems that differed between the centres in Aarhus and Copenhagen. In Aarhus, patients were immobilised by the stereotactic body frame (SBF; Elekta AB, Stockholm, Sweden) with an external reference coordinate system visible on CT and a diaphragm control that reduces the internal respiration related movement of the liver [6,7,9]. A maximum respiratory movement of the diaphragm of 10 mm during the respiratory cycle evaluated by fluoroscopy was allowed.…”

Section: Radiotherapymentioning

confidence: 99%

“…The efficacy of SBRT has primarily been investigated in the treatment of limited stage small cell lung cancer [7,8]. In the present study, SBRT was evaluated in patients with CRC metastases not amendable for surgery or other local treatment in a Danish joint prospective phase-II trial.…”

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Phase II study on stereotactic body radiotherapy of colorectal metastases

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Radiotherapymentioning

confidence: 99%

Section: Radiotherapymentioning

confidence: 99%

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confidence: 99%

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Phase II study on stereotactic body radiotherapy of colorectal metastases

et al. 2006

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“…Stereotactic body radiation therapy (SBRT) is emerging as an efficient treatment for Stage I/ II medical inoperable and surgically unresectable non-small-cell and metastatic lung cancer [1][2][3][4][5][6][7][8][9][10][11][12]. Dose escalation and hypofractional dose delivery has the potential to increase patients' survival rates [3] and the probability of local tumor control [4,6,8], while increasing median survival time and long-term progression-free survival [7].…”

Section: Introductionmentioning

confidence: 99%

An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors

Shekhar

et al. 2008

Radiotherapy and Oncology

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Purpose-To evaluate four planning techniques for stereotactic body radiation therapy (SBRT) in lung tumors.Methods and Materials-Four SBRT plans were performed for 12 patients with stage I/II nonsmall-cell lung cancer under the following conditions: (1) conventional margins on free-breathing CT (plan 1), (2) generation of an internal target volume (ITV) using 4DCT with beam delivery under free-breathing conditions (plan 2), (3) gating at end-exhale (plan 3), and (4) gating at end-inhale (plan 4). Planning was performed following the RTOG 0236 protocol with a prescription dose of 54Gy (3 fractions). For each plan 4D dose was calculated using deformable image registration.Results-There was no significant difference in tumor dose delivered by the 4 plans. However, compared with plan 1, plans 2-4 reduced total lung BED by 1.9±1.2Gy, 3.1±1.6Gy and 3.5±2.1Gy, reduced mean lung dose by 0.8±0.5Gy, 1.5±0.8Gy, and 1.6±1.0Gy, reduced V20 by 1.5±1.0%, 2.7 ±1.4%, and 2.8±1.8% respectively with p<0.01. Compared with plan 2, plans 3-4 reduced lung BED by 1.2±1.0Gy and 1.6±1.5Gy, reduced mean lung dose by 0.6±0.5Gy and 0.8±0.7Gy, reduced V20 by 1.2±1.1% and 1.3±1.5% respectively with p<0.01. The differences in lung BED, mean dose and V20 of plan 4 compared with plan 3 are insignificant.Conclusions-Tumor dose coverage was statistically insignificant between all plans. However, compared with plan 1, plans 2-4 significantly reduced lung doses. Compared with plan 2, plan 3-4 also reduced lung toxicity. The difference in lung doses between plan 3 and plan 4 was not significant.

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Stereotactic body radiotherapy: A critical review for nonradiation oncologists

Kirkpatrick

Kelsey

Palta

et al. 2013

Cancer

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Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate delivery of multiple radiation beams to the target. This is particularly challenging, because extracranial lesions often move with respiration and are irregular in shape, requiring careful treatment planning and continual management of this motion and patient position during irradiation. This review presents the rationale, process workflow, and technology for the safe and effective administration of SBRT, as well as the indications, outcome, and limitations for this technique in the treatment of lung cancer, liver cancer, and metastatic disease. Cancer 2014;120:942-54.

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Prospective Study on Stereotactic Radiotherapy of Limited Stage Non-Small Cell Lung Cancer

Cited by 23 publications

References 0 publications

Phase II study on stereotactic body radiotherapy of colorectal metastases

Phase II study on stereotactic body radiotherapy of colorectal metastases

An evaluation of planning techniques for stereotactic body radiation therapy in lung tumors

Stereotactic body radiotherapy: A critical review for nonradiation oncologists

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