Prospective Study of Uterine Leiomyomas I N a Tertiary Care Hospital

Abstract

BACKGROUND: Fibroids are benign smooth muscle neoplasms that may occur singly, but more often are multiple. Uterine tumors are the most common and the leading cause of hysterectomy in women. METHODS: The present study is a prospective study conducted in the department of pathology, Andhra Medical College, King George Hospital, Visakhapatnam in the period of one year, from March 2014 to March 2015. RESULTS: We received a total of 368 hysterectomy and 5 myomectomy specimens during this period, out of which, 249(66.7%) were single and 124(33.3%) were multiple. The age group ranged from 20 to 69. The most common location was intramural 243(65.1%) cases, subserosal were 51(13.7%), submucosal were 18(4.8%), cervical were 7(1.8%) and 2(0.5%) were broad ligament fibroids. The size ranged from as large as 19 cm to as small as seedling fibroids of size 0.1cm. Microscopically, the most common degeneration was hyaline degeneration 80 cases, 5 myxoid, 5 cystic and one case of chondroid degeneration. 6 cases showed calcifications. The most common age group was seen in the age group of 40-49 which were 207 cases (55.5%). 51(13.7%) cases were associated with adenomyosis. The results from our study were comparable with those reported in literature and provide a simple integrated pathogenetic view for further thinking, to establish new therapeutic options. CONCLUSIONS: The clinico-social and economic burden of uterine leiomyomas is increasing and requires future studies to clarify the etiopathogenesis and elaborate new and effective therapies for this condition.