Prospective risk of stillbirth in women with placental mesenchymal dysplasia

Abstract

18Aims: To provide better counsel to pregnant women with suspected placental 19 mesenchymal dysplasia (PMD) regarding the risks of preterm birth and intrauterine 20 fetal death (IUFD).

Placental mesenchymal dysplasia with a good outcome: A case report

“…In addition, as one of the specific causes of IUFD with PMD, fetomaternal hemorrhage is suggested . And, four IUFD/stillbirth cases out of 27 PMD cases (14.8%) seemed consistent with the rate as the complication of PMD based on previous studies . Given those conditions excluding BWS cases and including IUFD/still birth cases, the rate of infants heavier than 2500 g was 25% (1/4) in males and 17% (4/23) in females with an odds ratio of 1.58 ( P < 0.01).…”

“…We included those cases in analysis because a certain percentage of complication of IUFD/still birth is known to occur with PMD. Nayeri and Ishikawa reported 13% and 29.4% of women with PMD experienced stillbirth. And the prospective risk of stillbirth with PMD was significantly high at any GW of 24 or later with median GW of 31 .…”

“…Nayeri and Ishikawa reported 13% and 29.4% of women with PMD experienced stillbirth. And the prospective risk of stillbirth with PMD was significantly high at any GW of 24 or later with median GW of 31 . In addition, as one of the specific causes of IUFD with PMD, fetomaternal hemorrhage is suggested .…”

Placental mesenchymal dysplasia

“…Течение беременности при МДП, не связанной с синдромом Беквита-Видеманна, часто осложняется задержкой внутриутробного роста плода, невынашиванием, внутриутробной гипоксией [3,13]. Проспективный риск антенатальных потерь составляет 29,4% к сроку беременности 24 нед и 13% -36 нед [13].…”

“…Течение беременности при МДП, не связанной с синдромом Беквита-Видеманна, часто осложняется задержкой внутриутробного роста плода, невынашиванием, внутриутробной гипоксией [3,13]. Проспективный риск антенатальных потерь составляет 29,4% к сроку беременности 24 нед и 13% -36 нед [13]. Особенности течения неонатального периода изучены недостаточно; описаны случаи анемии и тромбоцитопении, ДВС-синдрома у новорожденных [14,15].…”