Highlights
This study investigated the difference between COVID-19 RCT in medRxiv and in PubMed.
SPIN in the conclusion was more frequently seen in reports in medRxiv than PubMed.
Readers should pay attention to the overstatements in preprints of COVID-19 RCT.
Placental mesenchymal dysplasia (PMD), characterized by an enlarged and thickened placenta with multiple hypoechoic cystic spaces, frequently leads to a poor infantile/fetal outcome. Here, we describe a case of PMD involving an infant delivered at term with a good outcome. The fetus was male, and the proportion of the PMD lesion to the entire placenta remained constant: the PMD lesion did not enlarge. Given what is known about the pathogenesis of PMD with its association with vascular endothelial growth factor-D (VEGF-D) encoded by an X-linked gene and androgenetic/biparental mosaicism, which is consistent with female dominancy and a poor outcome, we suggest that a male sex of the fetus and non-progressing PMD may have been associated with this good outcome.
Background: No studies have comprehensively assessed the quality of studies related to COVID-19 in preprints [11]. Hence, we will conduct a meta-epidemiological study based on the following research question: Are the quality of COVID-19 RCT and SR articles in medRxiv lower than those indexed in PubMed? Methods: We will conduct a meta-epidemiological cross-sectional study. We will include randomized controlled trial articles and systematic review articles indexed in PubMed or MedRxiv from 1 st January to 15 th June 2020. We will include articles of COVID-19 patients or healthcare workers engaged in the care of COVID-19 patients. We will exclude study protocols. We will evaluate the characteristics of included studies, methodological quality, number of mentions on social networking sites (SNS), and citations. We will use chi-squared test, logistic regression analysis, and linear regression analysis as appropriate. Two-tailed p values will be considered statistically significant if less than 0.05. Ethical consideration: We will only use openly available data. There is no need to make ethical considerations. ATTACHMENTS qor_preprints_protocol061 7v2.pdf
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.