Prospective application of exosomes derived from adipose‐derived stem cells in skin wound healing: A review

Abstract

Background: Wound healing has always been an intractable medical problem for both clinicians and researchers and a burden for patients both physically and financially. Poor wound healing at the injury site, especially in an exposed site, is associated with an unappealing esthetic appearance in patients and also results in a bad skin barrier, tissue infection and necrosis, loss of main function in extreme cases and other serious local and systemic consequences. There is a crucial and urgent need for newer, more efficacious methods for enhancing the healing process to achieve optimal outcomes morphologically and functionally. Recent advances have focused on developing therapies that promote tissue regeneration through positively activating the mechanism of tissue repair. Given the increasing high-quality studies concerning exosomes derived from adipose-derived stem cells (ADSCs-Exos), their potential use in accelerating or supporting the wound healing process has gained increasing attention in recent years. Aims:In this review, we present an overview of the recent advances in the field of ADSCs-Exos and investigate their benefit in wound healing for skin regeneration with the expectation of providing a perspective on how to best utilize this powerful cell-free therapy in the future. Methods:A retrospective review of the published data was conducted. Results: Most studies have shown the possible roles of ASCs-derived exosomes (ADSCs-Exos) in cutaneous wound healing through regulation of the inflammatory response and promotion of cell proliferation, migration, differentiation, angiogenesis and matrix reconstruction to provide a new perspective strategy for the use of ASCs-Exos in skin wound healing.Conclusion: ADSCs-Exos are likely to achieve the best functionally and cosmetic skin wound healing while avoiding undesirable consequences. ADSCs-Exos represent a novel therapeutic tool in soft tissue repair; however, further randomized, doubleblind, comparative clinical trials must be performed to determine the specific mechanisms, safety and other relevant cosmetic concerns. K E Y W O R D Sadipose-derived stem cell-derived exosomes, adipose-derived stem cells, exosome, skin regeneration, skin wound healing | 575 QIU et al.

Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway

“…However, MSCs transplantation may induce immunoreactivity to the host [4]. To avoid host-immunoreactivity, MSC-derived exosomes shows a alternative therapeutic attention for regenerative wound repair [5][6][7]. The current study has been demonstrated that MSC-derived exosomes accelerated the wound healing through increased reepithelialization, angiogenesis, and tissue granulation [6].…”

“…Recently, studies have shown that the prospective application of MSCs-derived exosomes promoted cutaneous wound healing [5,7,19]. The possible roles of MSCs-derived exosomes in wound healing through promotion of cell proliferation, migration, differentiation, angiogenesis and matrix reconstruction [6].…”

Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway

“…However, MSCs transplantation may induce immunoreactivity to the host [4]. To avoid host-immunoreactivity, MSC-derived exosomes shows a alternative therapeutic attention for regenerative wound repair [5][6][7]. The current study has been demonstrated that MSCderived exosomes accelerated the wound healing through increased re-epithelialization, angiogenesis, and tissue granulation [6].…”

Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery

“…Studies have shown that ASC-exos played a positive role in cutaneous wound healing by means of acting on HDFs and HaCaTs and other main target cells through various signal channels ( Figure 1C; Qiu et al, 2020). Ma et al (2019) exposed HaCaTs to hydrogen peroxide (H 2 O 2 ) for establishing a skin lesion model, discovering that ASC-exos could foster HaCaTs proliferation, migration, and inhibit apoptosis through Wnt/β-catenin signaling pathway.…”