Propranolol for the treatment of subglottic hemangiomas

Metry, Denise; Edmonds, Joseph L.; Chandy, Binoy; Sulek, Marcelle; Larrier, Deidre

doi:10.1016/j.ijporl.2011.08.017

Cited by 29 publications

(13 citation statements)

References 22 publications

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“…The primary exclusion criterion was the use of any intervention or medical therapy prior to propranolol. Twenty‐four studies published between 2009 and 2016 met all inclusion criteria to be included in the final review and analysis . Although our search began with articles in 2008, the first study meeting our inclusion criteria of primary treatment with propranolol was not published until 2009.…”

Section: Resultsmentioning

confidence: 99%

“…Although propranolol has become more widely accepted as a first‐line treatment in SGH, there are no standardized guidelines regarding treatment duration or optimal dosing. Although most studies indicate that propranolol is efficacious, there have been nonresponders reported, and there is limited information regarding rebound rates upon weaning or terminating propranolol . The occurrence of rebound growth in the subglottis could lead to significant airway compromise of the patient.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and rebound rates in propranolol‐treated subglottic hemangioma: A literature review

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy and rebound rates in propranolol‐treated subglottic hemangioma: A literature review

et al. 2017

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“…Since it was first reported in the therapy of IH, propranolol has become the first choice of therapy for complicated IH. Various therapeutic options have been utilized for treatment of LIH, including tracheotomy, open surgical excision, laser ablation, intralesional steroid injection, systemic steroids, and now oral propranolol (6). The proposed mechanism for the action of propranolol is that it induces vasoconstriction and capillary endothelial cell apoptosis (8).…”

Section: Discussionmentioning

confidence: 99%

“…Treatment should aim to reduce the size of the SGH, resolve symptoms and maintain stable lesion involution. Carefully administered, propranolol may demonstrate efficacy as a first-line agent in most cases, including severely respiratory compromised cases, avoiding surgery, tracheostomy, prolonged steroids, or as treatment of a diffuse and unresectable disease (6,9,10,11). However, some lesions may be resistant to propranolol and require surgery or longterm steroids (12).…”

Section: Discussionmentioning

confidence: 99%

Propranolol in the Treatment of Subglottic Haemangioma

et al. 2014

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Objective -Subglottic infantile haemangioma (SGH) is a rare but potentially life-threatening disease. We describe a case of successful treatment with propranolol of a severely respiratory compromised 2-month-old infant with an obstructing SGH. Case report -A fullterm 2-month-old male infant, weighing 4.8 kg, without cutaneous haemangioma, presented with stridor, dyspnoea, oxygen desaturation and tachycardia. Contrast enhanced neck-chest CT scan was used to diagnose a 5×7×7 mm subglottic elliptic lesion, referable to SGH with a free air column of 2 mm wide. Per oral propranolol was started with a therapeutic dosage of 2 mg/kg/day in 3 administrations. On the second day of treatment there was rapid clinical improvement of the infant with withdrawal of respiratory symptoms. After treatment, the control CT showed the regression of SGH. Twenty-one months later the patient is without respiratory symptoms. Conclusion -Propranolol medical treatment should be considered in all subglottic haemangioma, even in acute cases.

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“…Se aconseja realizar laringoscopía mensualmente para evaluar la vía área en estos pacientes [21][22][23][24] .…”

Section: Discussionunclassified

Hemangioma subglótico tratado con propranolol: Una nueva alternativa terapéutica. Caso clínico

2013

Rev. chil. pediatr.

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Propranolol for the treatment of subglotic hemangioma-A new therapeutic alternativeInfantile Subglottic Hemangiomas (ISH) are rare and potentially fatal. Many treatments have been described for this condition. Propranolol is a new therapeutic alternative, with successful results in skin and airway infantile hemangiomas. Case study: The case of an infant with ISH and 90% blockage of his airway is presented. The patient underwent a tracheostomy procedure and then treated with oral propranolol, showing a good response after a month of treatment, presenting 10% obstruction and consequently, ending the tracheostomy early. Conclusion: The discovery of the effect of propranolol in the ISH has revolutionized the management of this condition, displacing steroids and surgery as first-line treatments. This study discusses the current ISH management. RESUMENLos hemangiomas infantiles subglóticos (HIS) son poco frecuentes y potencialmente mortales. Muchos tratamientos se han descrito para los HIS. El propranolol es una nueva alternativa terapéutica, con resultados exitosos en hemangiomas infantiles de piel y de vía áerea. Caso clínico: Se reporta el manejo de un lactante con HIS que presentaba una obstrucción del 90% de su vía aérea, que debió ser traqueostomizado, luego se inicio propranolol oral, presentando una muy buena respuesta al mes de tratamiento, con 10% de obstrucción, retirando traqueostomía precozmente. Conclusión: El descubrimiento del efecto del propranolol en los HIS ha revolucionado su manejo, desplazando a los corticoides y a la cirugía como primera línea de tratamiento. En el presente reporte se discute el manejo actual de los HIS.

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Propranolol for the treatment of subglottic hemangiomas

Cited by 29 publications

References 22 publications

Efficacy and rebound rates in propranolol‐treated subglottic hemangioma: A literature review

Efficacy and rebound rates in propranolol‐treated subglottic hemangioma: A literature review

Propranolol in the Treatment of Subglottic Haemangioma

Hemangioma subglótico tratado con propranolol: Una nueva alternativa terapéutica. Caso clínico

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