The specifics of improving current regulatory acts on nuclear medicine under the conditions of the "regulatory guillotine" are considered. The current state of regulatory documentation on ensuring the radiation safety of patients, personnel, individuals from the population and the environment, as well as on assessing working conditions and pension provision for personnel of domestic nuclear medicine units, is analyzed. The presence of a large number of provisions that are scientifically unsubstantiated and inconsistent with international recommendations and many years of nuclear medicine practice is shown. A number of proposals have been developed to introduce appropriate amendments to regulatory documents intended for practical use after the end of the “regulatory guillotine”.