Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Shimizu, Jun; Wada-Funada, Urara; Miyata, Hiroshi; Matahira, Yoshiharu; Kawaguchi, Mitsuaki; Wada, Masahiro

doi:10.1248/jhs.51.394

Cited by 51 publications

(40 citation statements)

References 14 publications

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“…Frequencies of HTLV-1-specific CD8(+) T-cells, natural killer cells, invariant natural killer T-cells and dendritic cells in the peripheral blood were analyzed but did not show significant changes. This contrasts with research in which fucoidan intake did alter immune parameters [33,40]. In this clinical study, there were mild side effects.…”

Section: Therapies From Fucoidancontrasting

confidence: 89%

Therapies from Fucoidan; Multifunctional Marine Polymers

Fitton¹

2011

Marine Drugs

318

225

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Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.

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Section: Therapies From Fucoidancontrasting

confidence: 89%

Therapies from Fucoidan; Multifunctional Marine Polymers

Fitton¹

2011

Marine Drugs

318

225

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“…Shimizu et al (2005) reported that high-molecular-weight fucoidan extracted from Okinawa mozuku changed the ratio of CD4 + /CD8 + and increased the ratio of cytotoxic T cells in mice splenocytes. In the present study, all fractions had higher molecular weights than those previously reported (Lee et al 2004) from the same source; the molecular weight of fucoidan determined by their study was 9,000 kDa.…”

Section: Discussionmentioning

confidence: 99%

Growth-inhibitory effect of a fucoidan from brown seaweed Undaria pinnatifida on Plasmodium parasites

et al. 2008

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The present study was undertaken to investigate the inhibitory effects of fucoidan, a sulfated polysaccharide isolated from the edible brown seaweed Undaria pinnatifida, on the growth of Plasmodium parasites. In order to assess the anti-malarial activity of fucoidan, growth inhibition activities were evaluated using cultured Plasmodium falciparum parasites in vitro and on Plasmodium berghei-infected mice in vivo. Fucoidan significantly inhibited the invasion of erythrocytes by P. falciparum merozoites, and its 50% inhibition concentration was similar to those for the chloroquine-sensitive P. falciparum 3D7 strain and the chloroquine-resistant K1 strain. Four-day suppressive testing in P. berghei-infected mice with fucoidan resulted in a 37% suppressive effect versus the control group and a delay in death associated with anemia (P < 0.05). In addition, fucoidans had no toxic effect on RAW 264.7 cells. These findings indicate that fucoidans from the Korean brown algae U. pinnatifida inhibits the invasion of Plasmodium merozoites into erythrocytes in vitro and in vivo.

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“…However, it is different to use fucoidan because of its high molecular weight causing the bioavailability to be lower (Shimizu et al 2005). Therefore, reducing the molecular weight of fucoidan has been a topic of research (Colliec et al 1991).…”

Section: Effect Of Lmw Fucoidan and Fucoidan On Cell Viabilitymentioning

confidence: 99%

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

et al. 2015

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Osteoporosis has been reported as a hidden death factor in aged people. So far, prevention and treatment therapies for osteoporosis only slow down the progress but do not treat the disease. Fucoidan has been recognized its roles in anti-tumor, anti-inflammatory, anti-coagulant and antiviral activities. To date, low molecular weight (LMW) fucoidan role in bone loss disease has been not determined yet. Therefore, this study aims to figure out potential effects of LMW fucoidan in osteoporosis in vitro and in vivo. LMW fucoidan was extracted from fresh Sargassum hemiphyllum showing a significant increase in 7F2 cell viability to 150.33 ± 6.50 % relative to normal fucoidan (130.12 ± 5.74 %). The expression of level BMP-2, ALP, osteocalcin significantly increased with 2.28 ± 0.06, 2.18 ± 0.12 and 2.06 ± 0.07 fold, respectively. The RT-PCR assay showed that LMW fucoidan increased mRNA expression of BMP-2, ALP, osteocalcin, COL I, BSP and osteonectin. Furthermore, the bone density and bone ash weight were considerably boosted by the oral administration of280 mg/kg LMW fucoidan and 100 mg/kg calcium carbonate in C57BL/6J female aged mice. The present finding indicated that LMW fucoidan triggered osteogenic differentiation in vitro, and had an anabolic effect on bone mineralization in vivo. Dietary intake of LMW fucoidan from S. hemiphyllum suggested playing a role in the enhancement of bone loss with increasing age.

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Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)

Cited by 51 publications

References 14 publications

Therapies from Fucoidan; Multifunctional Marine Polymers

Therapies from Fucoidan; Multifunctional Marine Polymers

Growth-inhibitory effect of a fucoidan from brown seaweed Undaria pinnatifida on Plasmodium parasites

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

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