Therapies from Fucoidan; Multifunctional Marine Polymers

Fitton, J. Helen

doi:10.3390/md9101731

Cited by 320 publications

(246 citation statements)

References 118 publications

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“…Natural fucoidan has been reported to inhibit coated viruses such as HSV by blocking receptor-mediated entry and interfering with replication. 48 To determine whether these antiviral activities are retained in our synthetic glycopolymers, we tested the drug effect of glycopolymers in HSV-1-infected HCECs.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

Tengdelius¹,

Lee²,

Grenegård

et al. 2014

Biomacromolecules

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The sulfated marine polysaccharide fucoidan has been reported to have health benefits ranging from antivirus and anticancer properties to modulation of high blood pressure. Hence, they could enhance the biological function of materials for biomedical applications. However, the incorporation of fucoidan into biomaterials has been difficult, possibly due to its complex structure and lack of suitable functional groups for covalent anchoring to biomaterials. We have developed an approach for a rapid synthesis of fucoidan-mimetic glycopolymer chains through cyanoxyl-mediated free-radical polymerization, a method suitable for chain-end functionalizing and subsequent linkage to biomaterials. The resulting sulfated and nonsulfated methacrylamido α-L-fucoside glycopolymers' fucoidan-mimetic properties were studied in HSV-1 infection and platelet activation assays. The sulfated glycopolymer showed similar properties to natural fucoidan in inducing platelet activation and inhibiting HSV-1 binding and entry to cells, thus indicating successful syntheses of fucoidan-mimetic glycopolymers.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

Tengdelius¹,

Lee²,

Grenegård

et al. 2014

Biomacromolecules

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show abstract

“…The intensity of biological activities of fucoidan varies with species, molecular weight, composition, structure and the route of extraction (Fitton 2011), and its non-animal origin brings particular pharmacological activities (Senni et al 2006). Fucoidan has been well studied for its antitumor (Hsu et al 2013), antiviral (Tengdelius et al 2014), anti-inflammatory (Hwang et al 2011), and anticoagulant (Irhimeh et al 2009) activities.…”

Section: Introductionmentioning

confidence: 99%

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

et al. 2015

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Osteoporosis has been reported as a hidden death factor in aged people. So far, prevention and treatment therapies for osteoporosis only slow down the progress but do not treat the disease. Fucoidan has been recognized its roles in anti-tumor, anti-inflammatory, anti-coagulant and antiviral activities. To date, low molecular weight (LMW) fucoidan role in bone loss disease has been not determined yet. Therefore, this study aims to figure out potential effects of LMW fucoidan in osteoporosis in vitro and in vivo. LMW fucoidan was extracted from fresh Sargassum hemiphyllum showing a significant increase in 7F2 cell viability to 150.33 ± 6.50 % relative to normal fucoidan (130.12 ± 5.74 %). The expression of level BMP-2, ALP, osteocalcin significantly increased with 2.28 ± 0.06, 2.18 ± 0.12 and 2.06 ± 0.07 fold, respectively. The RT-PCR assay showed that LMW fucoidan increased mRNA expression of BMP-2, ALP, osteocalcin, COL I, BSP and osteonectin. Furthermore, the bone density and bone ash weight were considerably boosted by the oral administration of280 mg/kg LMW fucoidan and 100 mg/kg calcium carbonate in C57BL/6J female aged mice. The present finding indicated that LMW fucoidan triggered osteogenic differentiation in vitro, and had an anabolic effect on bone mineralization in vivo. Dietary intake of LMW fucoidan from S. hemiphyllum suggested playing a role in the enhancement of bone loss with increasing age.

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“…Fucoidan, a class of fucose-enriched sulfated polysaccharides, is a naturally occurring polysaccharide compound in brown alga, such as Fucus vesiculosus, Cladosiphon okamuranus and Laminaria saccharina [1,2] . It has recently been reported that fucoidan possesses a wide variety of biological activities, including anticoagulant, antiviral, antiangiogenic, anticancer and immune-modulatory activities [3] .…”

Section: Introductionmentioning

confidence: 99%

Fucoidan induces Apoptosis in MDA-MB-231 Cells by Activating Caspase Cascade and Down-regulating XIAP

Banafa¹,

Roshan²,

Liu³

et al. 2014

IOSRJPBS

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Summary: Previous studies have shown fucoidan could induce apoptosis in breast cancers, while the detailed mechanisms need to be investigated.Results of this study illustrated that number of viable MDA-MB-231 cells was decreased by fucoidan with a dose-dependent manner, while the fucoidan did not affect the viable epithelial cells number of normal human mammary (MCF10A).. After incubation with fucoidan, several apoptotic events such as chromatin condensation and increase of the population of G2/M phase were observed in MDA-MB-231 cells. RT-PCR and Western blot results showed that the activation of caspase cascade such caspase-3, caspase-8 and caspase-9, as well as the expression of XIAP (X-linked inhibitor of apoptosis protein), was involved in the apoptosis process. Besides that, reactive oxygen species(ROS) production was increased after fucoidan treatment. These results indicated that fucoidan could induce the apoptotic cell death through modulation of XIAP and caspases activation in MDA-MB-231 cells and could also induce the generation of ROS.

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Therapies from Fucoidan; Multifunctional Marine Polymers

Cited by 320 publications

References 118 publications

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

Fucoidan induces Apoptosis in MDA-MB-231 Cells by Activating Caspase Cascade and Down-regulating XIAP

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