Propolis from Different Geographic Origins Decreases Intestinal Inflammation and <i>Bacteroides</i> spp. Populations in a Model of DSS‐Induced Colitis

Wang, Kai; Jin, Xi; Li, Qiangqiang; Sawaya, Alexandra Christine Helena Frankland; Leu, Richard K. Le; Conlon, Michael A.; Wu, Liming; Hu, Fuliang

doi:10.1002/mnfr.201800080

Cited by 171 publications

(128 citation statements)

References 50 publications

(73 reference statements)

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“…Our previous studies also found that the Lonicera caerulea L. berry rich in C3G could attenuate inflammation potentially through the modulation of gut microbiota, especially the ratio of Firmicutes to Bacteroidetes in a mouse model of experimental non-alcoholic fatty liver disease [67]. Nevertheless, another study revealed that propolis rich in PCA, VA, and FA could suppress intestinal inflammation in a rat model of dextran sulfate sodium-induced colitis potentially by reducing the population of Bacteroides spp [68]. This may be because of the inhibitory and lethal effects on pathogenic bacteria by anthocyanins and their metabolites.…”

Section: Crosstalk Between Gut Microbiota and C3gandc3g-msmentioning

confidence: 93%

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

Tan

Hou

et al. 2019

Antioxidants

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Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.

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Section: Crosstalk Between Gut Microbiota and C3gandc3g-msmentioning

confidence: 93%

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

Tan

Hou

et al. 2019

Antioxidants

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“…Colonic histological damage was evaluated using a semi‐quantitative score. In brief, the score was based on cell infiltration (0–3, from rare inflammatory cells in the lamina propria to severe transmural extension of inflammatory cell infiltration) and tissue damage (0–3, from no mucosal damage to extensive mucosal damage and extension through deeper structures of the bowel wall) . The immunohistochemistry score was calculated by the following equation: Immunohistochemistry score = (percentage of cells of weak intensity × 1) + (percentage of cells of moderate intensity × 2) + (percentage of cells of strong intensity × 3).…”

Section: Methodsmentioning

confidence: 99%

Honey Polyphenols Ameliorate DSS‐Induced Ulcerative Colitis via Modulating Gut Microbiota in Rats

Zhao

Cheng

Zhou

et al. 2019

Molecular Nutrition Food Res

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Scope Ulcerative colitis (UC) is a multifaceted and recurrent immune disorder that requires long‐term potent pharmacological treatment. Honey, as a natural food of nourishment and pharmaceutical value, has been found to defend against colitis. Methods and results The effects of different constituents in honey are investigated on DSS‐induced colitis in rats. Rats are given DSS, sugars, honey, polyphenols, or SASP for a week, with blood and colon samples collected for the biochemical parameters and inflammation‐related gene analysis and colon contents for gut microbiota. The results show that pretreatments with honey polyphenols significantly improve SOD, GSH‐Px, NO, and MPO levels and reduce DSS‐induced colonic apoptosis, the colonic inflammatory cytokines IL‐6, TNF‐α, and TGF‐β1 accompanied by downregulation of IL‐1β, IL‐6, TNF‐α, and IFN‐γ gene and upregulation of IκB‐α gene. Furthermore, honey polyphenols and SASP show similar microbial community structure shifts and selective enrichment of key species. At the genus level, honey polyphenols significantly reduce the population of Bacteroides, Corynebacterium, and Proteus species. The correlation analysis indicates that colonic gene expression regulated by honey polyphenols is relative to the key species of gut microbiota. Conclusions Honey polyphenols improve intestinal inflammation and oxidative stress resistance via modulating gut microbiota, which is conducive to revealing the host–microbe interactions.

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“…Flavonoids are also regarded as the major active constituents of bee propolis, a natural dietary supplement produced by honeybees from the resin of plants which has been widely used to prevent inflammatory diseases [9]. Recent studies from our lab have also suggested that propolis flavonoids have considerable potential as complementary and alternative reagents relative to classical IBD therapeutics [10,11]. Nevertheless, propolis contains numerous flavonoids, and there is scant information regarding the active constituents in relation to its gastrointestinal effects.…”

Section: Introductionmentioning

confidence: 99%

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Han

Hao

et al. 2020

Nutrients

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Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed to investigate the preventive effects of galangin against dextran sulphate sodium (DSS)-induced acute murine colitis, which mimics the symptoms of human ulcerative colitis (UC). Pre-treatment with galangin (15 mg/kg, p.o.) resulted in a significant decreased in the macroscopic signs of DSS-induced colitic symptoms, including a decreased disease activity index, prevention of the colon length shortening, and alleviation of the pathological changes occurring in the colon. Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group. Moreover, galangin pre-treatment significantly increased the expressions of autophagy-related proteins and promoted the formation of autophagosome in the colon. Galangin pre-treatment increased the diversity of the gut microbiota, and this was accompanied by increased levels of short-chain fatty acids. These observed changes could involve the modulating effects conferred by galangin in relation to some specific bacteria populations, including the recovery of Lactobacillus spp., and increased Butyricimonas spp. Overall, these results support the use of galangin in the prevention of UC.

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Propolis from Different Geographic Origins Decreases Intestinal Inflammation and Bacteroides spp. Populations in a Model of DSS‐Induced Colitis

Abstract: Despite the dissimilar polyphenol compositions of CP and BP, their ability to protect against DSS-induced colitis is similar. Nevertheless, some different physiological impacts were observed.

Cited by 171 publications

References 50 publications

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

Honey Polyphenols Ameliorate DSS‐Induced Ulcerative Colitis via Modulating Gut Microbiota in Rats

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

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