Propofol Effect on Stress Response and Free Radicals in Patient during Surgery and Sedation Procedure

Rahardjo, Theresia Monica

doi:10.18585/inabj.v7i3.183

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…It causes smooth induction, rapid recovery with short half-life, and insignificant postoperative complications [ 30 ]. It has anti-stress and antioxidant properties [ 31 ]. Xylazine is an alpha2-adrenoceptor agonist that is used for premedication, sedation, and analgesia in small animal practice [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

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Aim:The importance of physical and psychological stress caused by pain during surgery cannot be overemphasized. The aim of this study was to assess the effects of ovariohysterectomy (OVH), gastrotomy (GST), and intestinal resection and anastomosis (IRA) on biochemical parameters of Nigerian dogs anesthetized with the xylazine-propofol combination.Materials and Methods:A total of 12 dogs were randomly divided into three groups of four each. The animals were treated with xylazine and propofol anesthetics for OVH, GST, and IRA in Groups 1-3, respectively. Blood samples were collected at 0 h, 2, 24, 48, 72, 96, 120, and 144 h postsurgery for determination of cortisol (CORT), glucose (GLU), total protein (TP), albumin (ALB), globulin (GL), and ALB/GL ratio.Results:There were significant increases (p<0.05) in mean CORT concentrations 2 h postsurgery in the three groups and at 24 h in Group 3 and 96 h in Groups 1 and 3, respectively. GLU concentrations increased significantly (p<0.05) in the three groups at 2 h postsurgery. The mean protein concentrations in Groups 2 and 3 decreased significantly (p<0.05) at 2h and 24 h and 72 h, 96 h, 120 h, and 144 h in Group 3, respectively. There was significant decrease (p<0.05) in the mean ALB concentrations at 2 h, 24 h, 72 h, 96 h, 120 h, and 144 h postsurgery. There was a significant difference (p<0.05) in the mean GL concentrations in Group 3 at 24 h, 72 h, 96 h, and 144 h. All other parameters were not significantly different (p>0.05) in comparison with the control.Conclusion:Xylazine-propofol combination could decrease humoral immune status and increase serum GLU level invariably portending a high risk of diabetes in the vulnerable dogs.

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Section: Introductionmentioning

confidence: 99%

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

2018

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“…Recoveries in dogs are reported to be smooth in propofol anesthesia [2]. Respiratory depression and apnea are the most common adverse effects associated with IV administration of propofol [3] along with pain on injection [4]. …”

Section: Introductionmentioning

confidence: 99%

Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs

Anandmay¹,

Dass²,

Sharma³

et al. 2016

Vet World

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Aim:The aim of this study is to find out the effect of propofol and its combination with meperidine and pentazocine lactate on certain clinico-anesthetic profiles in dogs.Materials and Methods:15 apparently healthy mongrel dogs of either sex of about 1 year of age were randomly divided into three groups of five dogs each. The animals of Group I were administered propofol intravenously alone “to effect,” whereas meperidine at 2 mg/kgb.wt. and pentazocine lactate at 2 mg/kg b.wt. were injected intramuscularly 15 min before propofol “to effect” in Groups II and III, respectively. Atropine sulfate at 0.04 mg/kgb.wt. was injected intramuscularly 20 min before each treatment. Rectal temperature, heart rate, respiration rate, and anesthetic indices were recorded before and at 5, 10, 20, 30, and 60 min of induction.Results:As compared to Group I, the animals of Groups II and III exhibited a significant decrease (p<0.05) in the level of rectal temperature, respiration rate, and heart rate. Duration of recumbency, time of standing, time of recovery as well as the duration of analgesia were longer in pentazocine lactate (Group III) followed by meperidine (Group II) as compared to propofol alone (Group I). Meperidine treated dogs showed defecation and muscle twitching during anesthesia.Conclusion:Meperidine and pentazocine are suitable opioids used in combination with propofol for achieving surgical anesthesia and helpful in reduction of propofol dose.

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Propofol Effect on Stress Response and Free Radicals in Patient during Surgery and Sedation Procedure

Cited by 2 publications

References 13 publications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Effects of various surgical procedures on biochemical parameters of Nigerian dogs and their clinical implications

Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs

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