Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs

Anandmay, Anand Kumar; Dass, L. L.; Sharma, Arvind Kumar; Gupta, M. K.; Singh, Kamla; Roy, B. K.

doi:10.14202/vetworld.2016.1178-1183

Cited by 6 publications

(5 citation statements)

References 27 publications

(29 reference statements)

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“…and 28.00±2.00 sec. after administration of propofol alone and in combination with buprenorphine in dogs (Anandmay et al, 2012). Rapid onset of anaesthesia was recorded in all the three groups in the present study which might be due to the high lipid solubility of propofol and ability to rapidly cross blood-brain barrier.…”

Section: Clinical Parametersmentioning

confidence: 45%

“…Opioids in combination with propofol increase the probability of respiratory depression during anaesthesia (Short and Bufalari, 1999). Similarly, Anandmay et al (2012) also reported significant decrease in respiration rate after propofol alone and in combination with buprenorphine in atropinized dog. Severe respiratory depression was recorded in group DP due to synergistic effect of dexmedetomidine and propofol.…”

Section: Respiration Rate (Breaths Per Minute)mentioning

confidence: 82%

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Clinico-Physiological and Haemodynamic Alterations Following Propofol Induction and Premedication with Butorphanol, Dexmedetomidine or Acepromazine in Dogs

Dewangan,

Pal,

Sharda

et al. 2024

IJBSM

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The present study was conducted during February-October 2021 at Department of Veterinary Surgery and Radiology, College of Veterinary Science & A.H. Anjora, Durg (C.G.), India to evaluate the alternations on clinico-physiological and haemodynamic parameters following propofol induction in dogs premedicated with butorphanol or dexmedetomidine or acepromazine. Eighteen adult dogs of either sex were randomly divided into three groups (BP, DP and AP) with six animals in each. Ten minutes prior to the anaesthetic administration, all the dogs were administered glycopyrrolate @ 0.02 mg kg-1 I/M. The animals of group BP, DP and AP were premedicated intramuscularly with butorphanol @ 0.3 mg kg-1 b.wt., dexmedetomidine @ 10 µg kg-1 b.wt. and acepromazine @ 0.4 mg kg-1 b.wt. respectively. General anaesthesia was induced with propofol @ 7 mg kg-1 b.wt. intravenously. Clinical parameters were recorded following induction with propofol. Physiological and haemodynamic parameters were recorded before (0), 5 min. after sedation, induction and at 10, 20, 40, 60 and 120 min. post propofol anaesthesia. The onset of sedation and anaesthesia was quicker in group DP followed by AP and BP. Duration of anaesthesia and complete recovery were significantly (p<0.05) longer in group DP as compared to group BP and AP. The physiological and haemodynamic parameters showed transient changes which were compensated and remained within normal range during the study period without producing any deleterious effect. Thus, propofol can be safely used as induction agent in dogs premedicated with either dexmedetomidine or butorphanol or acepromazine and does not produce any adverse effect on cardiopulmonary system. However, dexmedetomidine-propofol combination provided longer duration of anaesthesia in dogs as compared to other groups.

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Section: Clinical Parametersmentioning

confidence: 45%

Section: Respiration Rate (Breaths Per Minute)mentioning

confidence: 82%

Clinico-Physiological and Haemodynamic Alterations Following Propofol Induction and Premedication with Butorphanol, Dexmedetomidine or Acepromazine in Dogs

Dewangan,

Pal,

Sharda

et al. 2024

IJBSM

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“…Animals in all the three groups showed smooth transition with no paddling (score 0) to occasional, slow paddling (score 1) movements while induction stage. Lower induction time noticed in group-T and group-P might be due to synergistic effect of opioids and propofol (Anandmay et al, 2016).…”

Section: Quality Of Inductionmentioning

confidence: 84%

Evaluation of Tramadol, Pentazocine Lactate and Meloxicam as Pre-emptive Analgesics for Pain Management in Canine Ovariohysterectomy

Chaithra

Saikia

Konwar

et al. 2021

IJAR

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Background: It is usually accepted that some degree of post-surgical pain will be commonly present. There are different pain scales adopted in veterinary practice to assess these behavioural signs to measure pain. VAS had been used in human medicine for many years to measure pain and was found equally satisfactory in dogs. Pre-emptive analgesia (PEA) is grasping popularity in recent days, the concept of which originated during the time of growing appreciation of dynamic characteristics of pain pathway for obtaining effective analgesia prior to the surgical trauma. Methods: The present study was conducted to evaluate the effects of tramadol, pentazocine lactate and meloxicam as pre-emptive analgesics in dogs premedicated with glycopyrrolate, induction and maintenance with propofol continuous rate infusion (CRI) for certain clinical and physiological parameters. The animals were randomly divided into three equal groups viz. Group-T, Group-P and Group-M comprising six animals in each group and all were premedicated with glycopyrrolate, I/M. After 10 minutes of pre-anaesthetic administration, pre-emptive analgesia was given (Tramadol in Group-T, Pentazocine lactate in Group-P and Meloxicam in Group-M intravenously). After 10 minutes of pre-emptive analgesic administration, induction was achieved with propofol I/V and also maintained by CRI method up to 1 hour. Clinical and physiological parameters were recorded at 0 (baseline) minute before premedication, thereafter at 10 min, 30 min, 1 hr, 2 hr and 3 hr after pre-emptive analgesic administration. Result: There was no sedation observed within 10 min following pre-emptive analgesia and quality of sedation was recorded as score-0 in all the groups. Time for induction was significantly higher in group-M as compared to group-T and P. Quality of induction in all the groups ranged from score-0 to score1, assessment of peri-operative analgesia was recorded as score-0 in group-T and group-P, whereas in group-M it ranged from score-0 to score-1. Depth of anaesthesia was recorded as score-0 to score-1 in all the groups and quality of recovery was recorded as score-0 to score-1 in group-T and group-P and score-1 to score-2 in group-M. Assessment of post-operative analgesia by VAS was significantly lower in group-T as compared to group-P and M. In all the three groups, the heart rate increased significantly at 30 min interval and thereafter it decreased significantly till the end of the study. Respiratory rate also decreased significantly till 1 hr and thereafter it gradually increased till the end of study in all the groups. Rectal temperature, SpO2, systolic pressure and diastolic pressure decreased significantly at 30 min and thereafter increased gradually and approached base values in all the groups.

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“…Pentazocine is used to control mild to moderate postoperative pain. Pentazocine is more or less tolerable in most Dogs but acute toxicity may result in sinus tachycardia, hypotension, hypoventilation and Nystagmus [8].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Nalbuphine and Pentazocine in Controlling Postoperative Pain in Dogs

Rabbani¹,

Hayat²,

Gardezi³

et al. 2018

Matrix sci. medica

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Surgical success in most cases is governed by the quality of post-operative pain management. In Pakistan, most veterinary surgeons face a dire predicament as they fail astutely in this regard. Owing to the controlled dispensing of potent narcotics and their potential misuse, an imperative need for effective post-operative analgesic management of pain exists in dogs. 32 dogs were randomly divided into two groups. Group A was injected Nalbuphine @ 0.5 mg/kg post-operatively while Group B was injected Pentazocine @ 3mg/kg. Subjective and objective analysis of pain was conducted by unbiased observers. Vital signs (Temperature, pulse, respiration) were analyzed along with supplementation of hepatic and renal function tests. Objective and subjective analysis of both groups yielded results in the favor of pentazocine. In group A, temperature, pulse and respiration averaged 101.86±0.58 o F, 83.46±2.75 per minute and 19.26±2.14 per minute respectively. Group 2 demonstrated temperature, pulse and respiration averages of 102.31±0.40 o F, 83.41±2.74 per minute and 19.54±2.14 per minute respectively. Values of hepatic and renal function were also observed to be significantly higher in Nalbuphine treated group. All the results indicate that pentazocine is not only a significantly better analgesic but also has lower hepatotoxic and renal toxic effects.

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Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs

Cited by 6 publications

References 27 publications

Clinico-Physiological and Haemodynamic Alterations Following Propofol Induction and Premedication with Butorphanol, Dexmedetomidine or Acepromazine in Dogs

Clinico-Physiological and Haemodynamic Alterations Following Propofol Induction and Premedication with Butorphanol, Dexmedetomidine or Acepromazine in Dogs

Evaluation of Tramadol, Pentazocine Lactate and Meloxicam as Pre-emptive Analgesics for Pain Management in Canine Ovariohysterectomy

A Comparison of Nalbuphine and Pentazocine in Controlling Postoperative Pain in Dogs

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