Prophylaxe und Therapie akuter Strahlenfolgen an Haut und Schleimhaut

Zimmermann, J.; Wilhelm, R.; Niehoff, Peter; Schneider, R.; Kovács, G.; Kimmig, B.

doi:10.1007/bf03038497

Cited by 21 publications

(16 citation statements)

References 12 publications

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“…The Consensus Development Panel of the National Institutes of Health (Consensus statement, 1990) stated that no drugs can prevent mucositis, an opinion that still holds true to date (Scully and Epstein, 1996;Zimmermann et al, 1998;Karthaus et al, 1999;Plevovà,1999;Sonis et al, 1999;Sutherland and Browman, 2001). Consequently, prevention of mucositis is still limited to reduction of its severity by oral care programs, relief of pain and discomfort, and/or strategies to eliminate micro-organisms that are thought to be involved in the development or promotion of radiation mucositis.…”

Section: Mucositismentioning

confidence: 99%

“…Currently, most oral care programs aim at: removal of mucosal-irritating factors, cleansing of the oral mucosa, maintaining the moisture of the lips and the oral cavity, relief of mucosal pain and inflammation, and prevention or treatment of infection (Miaskowski, 1990;Scully and Epstein, 1996;Zimmermann et al, 1998). Although it has been suggested that good oral hygiene may reduce the development and severity of mucositis, no controlled studies of large numbers of patients have yet been undertaken.…”

Section: Mucositismentioning

confidence: 99%

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Prevention and Treatment of the Consequences of Head and Neck Radiotherapy

Vissink

Burlage

Spijkervet

et al. 2003

Critical Reviews in Oral Biology & Medicine

330

209

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The location of the primary tumor or lymph node metastases dictates the inclusion of the oral cavity, salivary glands, and jaws in the radiation treatment portals for patients who have head and neck cancer. The clinical sequelae of the radiation treatment include mucositis, hyposalivation, loss of taste, osteoradionecrosis, radiation caries, and trismus. These sequelae may be dose-limiting and have a tremendous effect on the patient's quality of life. Most treatment protocols to prevent these sequelae are still based on clinical experience, but alternatives based on fundamental basic and clinical research are becoming more and more available. Many of these alternatives either need further study before they can be incorporated into the protocols commonly used to prevent and treat the radiation-related oral sequelae or await implementation of these protocols. In this review, the various possibilities for prevention and/or treatment of radiation-induced changes in healthy oral tissues and their consequences are discussed.

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Section: Mucositismentioning

confidence: 99%

Section: Mucositismentioning

confidence: 99%

Prevention and Treatment of the Consequences of Head and Neck Radiotherapy

Vissink

Burlage

Spijkervet

et al. 2003

Critical Reviews in Oral Biology & Medicine

330

209

View full text Add to dashboard Cite

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“…As progress has been made in understanding the pathophysiology of RIF lesions, different treatment strategies have been developed in clinical practice. These consist of anti‐oxidants (vitamin‐E [13], superoxide dismutase [14]), angiotensin‐converting enzyme inhibitor (Captopril [14]), interferon‐gamma [15], anti‐inflammatory agents (Brufen [16]) and Pentoxifylline (Trental) [17]. However, all the studies of these strategies were performed in patients with acute radiation morbidity and the results, if any, were short‐lived [13].…”

Section: Discussionmentioning

confidence: 99%

Partial Mastectomy and M. Latissimus Dorsi Reconstruction for Radiation‐induced Fibrosis After Breast‐conserving Cancer Therapy

et al. 2010

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BackgroundPatients with severe complaints of radiation-induced fibrosis after breast-conserving therapy and not responding to conservative therapy, were treated by partial mastectomy and m. latissimus dorsi reconstruction.MethodTo determine the feasibility and outcome of this approach, a retrospective study of nine patients was carried out.ResultsAfter a mean follow-up of 46 months, eight of the nine patients experienced improvement of their complaints and shape of the breast. In only one case did the procedure fail, as evidenced by continuation of all complaints.ConclusionsPartial mastectomy and m. latissimus dorsi reconstruction is the ultimate option in the treatment of radiation fibrosis. The procedure is safe with satisfying results.

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“…The acute and late radiation related morbidity influences the patients quality of life in radiotherapy and it is hard to treat [1]. It is possible, that the difference in the intrinsic radio-sensitivity predisposes individuals to develop more severe side effects.…”

Section: Introductionmentioning

confidence: 99%

Clinical, Molecular- and Cytogenetic Analysis of a Case of Severe Radio- Sensitivity

Greulich-Bode

Zimmermann

Müller³

et al. 2012

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In radiotherapy the normal tissue reaction is often a limiting factor for radiation treatment. Still there is no screening method, which predicts normal tissue reaction on radiotherapy, especially in comparison to tumor tissue, and therefore allows tailoring of the radiation dose to each patient. Here, we present a case of severe radiation-related side effects. We applied classical cytogenetic techniques (Giemsa-banding and staining of centromeric regions), the comet assay as well as multicolor fluorescence in situ hybridization on peripheral blood lymphocytes of this patient in order to determine the radio-sensitivity on the DNA level and to correlate these findings with the clinical outcome. Our investigations revealed abnormalities on chromosome 9, deficiencies in the DNA-repair capacity after radiation exposure and a high number of radiation induced chromosomal aberrations. A detected high amount of residual damage two or three hours after radiation exposure and repair as well as the high number of chromosomal aberrations (ChAs) suggests a correlation between repair capacity and radiation induced ChAs. We concluded that the detected abnormalities might serve as a genetic basis for the radio-sensitive phenotype of this patient. Taken together this report strengthens the idea that intensive DNA genomic analysis of individual patients can serve as the basis for more favourable treatment of cancer patients.

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Prophylaxe und Therapie akuter Strahlenfolgen an Haut und Schleimhaut

Cited by 21 publications

References 12 publications

Prevention and Treatment of the Consequences of Head and Neck Radiotherapy

Prevention and Treatment of the Consequences of Head and Neck Radiotherapy

Partial Mastectomy and M. Latissimus Dorsi Reconstruction for Radiation‐induced Fibrosis After Breast‐conserving Cancer Therapy

Clinical, Molecular- and Cytogenetic Analysis of a Case of Severe Radio- Sensitivity

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