Partial Mastectomy and M. Latissimus Dorsi Reconstruction for Radiation‐induced Fibrosis After Breast‐conserving Cancer Therapy

Geel, Albertus N. van; Lans, Titia E.; Haen, Roel; Wai, R. Tjong Joe; Menke-Pluijmers, Marian B. E.

doi:10.1007/s00268-010-0911-8

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…The exceptional situation is the suspicion of tumor recurrence or second cancer formation where surgical approach is preferable over conservative methods or observation. One publication describes a study performed on a small group of patients with severe RIF after breast conserving therapy for breast cancer 83. In these patients, surgeons performed partial mastectomy and latissimus dorsi muscle reconstruction obtaining a satisfactory reduction of symptoms.…”

Section: Treatmentmentioning

confidence: 99%

Chronic radiation-induced dermatitis: challenges and solutions

Spałek

2016

CCID

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Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients’ quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers. The most severe complication of irradiation is extensive radiation-induced fibrosis (RIF). RIF can manifest in many ways, such as skin induration and retraction, lymphedema or restriction of joint motion. Diagnosis of chronic radiation dermatitis is usually made by clinical examination. In case of unclear clinical manifestation, a biopsy and histopathological examination are recommended to exclude secondary malignancy. The most effective prophylaxis of chronic radiation dermatitis is the use of proper radiation therapy techniques to avoid unnecessary irradiation of healthy skin. Treatment of chronic radiation dermatitis is demanding. The majority of the interventions are based only on clinical practice. Telangiectasia may be treated with pulse dye laser therapy. Chronic postirradiation wounds need special dressings. In case of necrosis or severe ulceration, surgical intervention may be considered. Management of RIF should be complex. Available methods are rehabilitative care, pharmacotherapy, hyperbaric oxygen therapy, and laser therapy. Future challenges include the assessment of late skin toxicity in modern irradiation techniques. Special attention should be paid on genomics and radiomics that allow scientists and clinicians to select patients who are at risk of the development of chronic radiation dermatitis. Novel treatment methods and clinical trials are strongly needed to provide more efficacious therapies.

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Section: Treatmentmentioning

confidence: 99%

Chronic radiation-induced dermatitis: challenges and solutions

Spałek

2016

CCID

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“…Screening and diagnosis of breast cancer can be done by physical examination by qualified healthcare provider, mammography, ductography, ultrasonography or MRI. Though surgery remains the mainstay of breast cancer treatment [7][8][9], other frontline therapeutic approaches are radiation therapy, hormone therapy, chemotherapy or monoclonal antibody based targeted therapy [10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Butea Monosperma Shows Anti-cancer and Anti-Oxidant Activity: In-vitro and In vivo Study

Ajmire

Patel

Kayande³

et al. 2021

JPRI

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Breast cancer is one of the predominant cancers in Indian subcontinent and the global scenario is not very different. Treatment of this type of cancer is possible by chemotherapy, surgery, and radiotherapy, which relieve the patient; however, off target activity and severe toxicity of non-cancerous cells remained the major drawbacks of these chemotherapeutics. In order to overcome these issues, modern cancer therapeutics emphasizes the implication of natural bioactive compounds. In this current piece of work, we have studied the anti-cancer potentiality of Butea monosperma flower in in vitro breast cancer cells. Various extracts of this flower were found to be non-toxic to breast epithelial cells but toxic to breast cancer cells. However, the methanol extract of this flower was most effective amongst all other extracts. Data suggest that Butea monosperma flower induce DNA damage mediated apoptosis and inhibit cell proliferation, angiogenesis and metastasis. It also inhibits the angiogenesis and metastasis in xenograft mice model system. Moreover, the anti-cancer phenomenon was found to be induction of inflammatory cytokines mediated oxidative stress in breast cancer. Collectively, Butea monosperma flower shows excellent cancer therapeutics in order to induce DNA damage, inhibit angiogenesis and metastasis simultaneously.

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“…The autologous reconstruction methods that are most used are breast reconstruction using a transverse rectus abdominis musculocutaneous flap and breast reconstruction using a latissimus dorsi flap, which provide safety and satisfaction for patients and improve their quality of life. 2 , 8 , 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

Patient satisfaction with breast reconstructionusing musculocutaneous flap from latissimus dorsiversus from rectus abdominis: a cross-sectional study

et al. 2018

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Breast cancer is the second most frequent type of cancer in the world and the most common type among women. Overall, it accounts for 28% of new cases of cancer. 1 In developed countries, the five-year survival rate is about 85%, whereas in developing countries, it remains between 50 and 60%. 1 It has been estimated that there will be 59,700 new cases of breast cancer in Brazil in 2018, i.e. 56.33 cases per 100,000 women. 1 Therapeutic and technological advances relating to breast cancer have allowed patients to attain greater life spans, and this has drawn attention to the quality of life of these women. 2-4 Mastectomy is considered to be one of the most devastating types of cancer treatment from a psychological point of view, in that it affects the self-esteem, femininity and body image of these patients. 5,6 However, breast reconstruction can be undertaken immediately after mastectomy or as a delayed procedure. Breast reconstruction procedures have positive impacts on all aspects of quality of life, including body image, particularly among younger women. 2,7 There are several types of breast reconstruction. The autologous reconstruction methods that are most used are breast reconstruction using a transverse rectus abdominis musculocutaneous flap and breast reconstruction using a latissimus dorsi flap, which provide safety and satisfaction for patients and improve their quality of life. 2,8,9,10 Anderson et al. developed a specific questionnaire for patients with breast diseases (named the Breast Evaluation Questionnaire) that has proven to be reliable and valid. It contains 55 questions and was developed to assess patients' satisfaction with their breasts and their contentment

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Partial Mastectomy and M. Latissimus Dorsi Reconstruction for Radiation‐induced Fibrosis After Breast‐conserving Cancer Therapy

Cited by 10 publications

References 27 publications

Chronic radiation-induced dermatitis: challenges and solutions

Chronic radiation-induced dermatitis: challenges and solutions

Butea Monosperma Shows Anti-cancer and Anti-Oxidant Activity: In-vitro and In vivo Study

Patient satisfaction with breast reconstructionusing musculocutaneous flap from latissimus dorsiversus from rectus abdominis: a cross-sectional study

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