Prophylactic Zinc and Therapeutic Selenium Administration Increases the Antioxidant Enzyme Activity in the Rat Temporoparietal Cortex and Improves Memory after a Transient Hypoxia‐Ischemia

Tomás-Sanchez, Constantino; Blanco-Álvarez, Víctor Manuel; Martínez‐Fong, Daniel; Gonzalez-Barrios, Juan-Antonio; Gonzalez-Vazquez, Alejandro; Aguilar-Peralta, Ana Karina; Torres-Soto, Maricela; Soto-Rodríguez, Guadalupe; Limón, Ilhuicamina Daniel; Brambila, Eduardo; Millán-Pérez-Peña, Lourdes; Cebada, Jorge; Orozco-Barrios, Carlos E.; León-Chávez, Bertha Alicia

doi:10.1155/2018/9416432

Cited by 20 publications

(16 citation statements)

References 75 publications

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“…In the same sense with the current findings, a wide variety of animal and human researches have shown an increase in SOD and GSH-Px activity and decrease in MDA, TNFα, and IL-6 with zinc and selenium intake (Asri-Rezaei et al, 2015;El-Demerdash & Nasr, 2014;Hasani et al, 2019;Nido et al, 2016;Prasad, 2014;Tomas-Sanchez et al, 2018;Zhang et al, 2018). Of course, in our study, supplementation with zinc despite increasing the amount of GSH-Px compared to the high-fat group, but it was marginally significant in WAT that one of the reasons could be the low sample size, which affects the amount of P. value or power of statistical tests.…”

Section: F I G U R E 5 Diagram Of Leptin Role As a Mediatorsupporting

confidence: 85%

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Hasani

Saidpour

Irandoost

et al. 2021

Food Science & Nutrition

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This research investigated the effect of co‐supplementation of selenium with zinc on weight control and the inflammatory and oxidative status in relation to obesity. Male Wistar rats (N = 32) were randomly divided into four groups after induction of obesity model: 1) “Zn” was supplemented with zinc sulfate (15 mg/kg BW), 2) “Se” supplemented with selenium as sodium selenate (0.5 mg/kg BW), 3) “Zn + Se” which received Zn (15 mg/kg BW) + Se (0.5 mg/kg BW), and 4) “HFD” as the control group. The intervention was done for eight weeks. At the end of treatment, serum and tissue level of Zn, Se, SOD, GSH‐Px, MDA, leptin, TNF‐α, and IL‐6 was evaluated. Weight and food intake were significantly reduced in the Se group(p < .001), while in the Zn group, weight gain due to obesity was prevented compared to the control group (p = .48). There was a significant and stronger increase in SOD, GSH‐Px levels and a remarkable decrease in MDA, leptin, TNF‐α, and IL‐6 in the group receiving the combination of two supplements than either alone(p < .001). Leptin had a positive correlation with inflammatory factors and lipid peroxidation marker and showed an inverse relationship with Zn and Se levels and anti‐oxidative enzymes(p < .05). The analysis showed the mediating role of leptin in the effects of zinc. Co‐supplementation of selenium and zinc may have a synergistic effect in reduction of oxidative and inflammatory markers. Regarding the effect of zinc on inflammatory factors and lipid peroxidation, leptin can play a mediating role.

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Section: F I G U R E 5 Diagram Of Leptin Role As a Mediatorsupporting

confidence: 85%

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Hasani

Saidpour

Irandoost

et al. 2021

Food Science & Nutrition

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“…Zn is present in cytosolic SOD (SOD1). Mn is well-known for mitochondrial SOD (SOD2), while Se is a co-enzyme of GPx [ 82 , 83 , 84 ].…”

Section: Antioxidants and The Maintenance Of Neutrophilic Tonementioning

confidence: 99%

Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)

2018

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Redox homeostasis may be defined as the dynamic equilibrium between electrophiles and nucleophiles to maintain the optimum redox steady state. This mechanism involves complex reactions, including nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, activated by oxidative stress in order to restore the redox balance. The ability to maintain the optimal redox homeostasis is fundamental for preserving physiological functions and preventing phenotypic shift toward pathological conditions. Here, we reviewed mechanisms involved in redox homeostasis and how certain natural compounds regulate the nucleophilic tone. In addition, we focused on the antioxidant properties of rice and particularly on its bioactive compound, γ-oryzanol. It is well known that γ-oryzanol exerts a variety of beneficial effects mediated by its antioxidant properties. Recently, γ-oryzanol was also found as a Nrf2 inducer, resulting in nucleophilic tone regulation and making rice a para-hormetic food.

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“…Inflammatory response may extend the damage due to ischemia and reperfusion injury as the latter may trigger release of inflammatory cytokines [25]. IL-6 may be one of the important mediators of inflammatory response during cerebral ischemia and reperfusion injury [10,26].…”

Section: Discussionmentioning

confidence: 99%

Cerebro-Protective effect of bosentan in brain ischemia reperfusion injury

Al-Mudhafar¹,

Hussien²,

AlHassani³

et al. 2019

AHRO

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Background: Ischemia reperfusion injury following acute ischemic insult is responsible for extension of injury.Bosentan is an endothelin receptor antagonist, which is currently used as a strong vasoconstrictor. This study aims to investigate the effects of bosentan on ischemia reperfusion injury after brain ischemic stroke in rat model. Methods: Forty male Wistar rats were randomly allocated into four study groups: Sham group: Rats underwent the anesthesia & surgery for an identical period to the other 3 study groups without intervention. Control group: Rats underwent anesthesia & surgery including bilateral common carotid artery ligation (BCCAL) for 30 minutes and then reperfusion for 1 hour. Vehicle group: Four days before ischemia, rats were administered with a vehicle (5% gummi arabicum) and then anesthesia &BCCAL surgery were performed. Bosentan treat group: Four days before Al-Aubaidy et al (2019): Bosentan effect in brain ischemia September 2019 Vol. 22(IV) ©Annals of Tropical Medicine & Public Health SPe145ischemia, rats were administered with bosentan (100mg/ kg/day) and then anesthesia & BCCAL surgery were performed.Results: Bosentan treated group exhibited lower concentration of interleukin 6 (IL-6)in the brain (2168.0±30.67 pg/mL) than in the control group (2571.37±96.58 pg/mL) (P≤0.05). In addition, interleukin 10 (IL-10) levels were significantly high in the bosentan group (275.7±15.97 pg/mL) when compared to the control group (244.05±12.23 pg/mL) (P≤0.05). This was associated with a non-significant reduction in the brain levels of endothelia nitric oxide synthase (eNOS) in the bosentan treated groups (90.23±1.14 ng/mL) when compared to the control group (90.94±2.48), (P>0.05). Conclusion:Bosentan treatment have protective effects against the inflammatory damage following ischemia reperfusion injury following acute myocardial infarction.

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Prophylactic Zinc and Therapeutic Selenium Administration Increases the Antioxidant Enzyme Activity in the Rat Temporoparietal Cortex and Improves Memory after a Transient Hypoxia‐Ischemia

Cited by 20 publications

References 75 publications

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Redox Homeostasis and Natural Dietary Compounds: Focusing on Antioxidants of Rice (Oryza sativa L.)

Cerebro-Protective effect of bosentan in brain ischemia reperfusion injury

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