Prophylactic and curative effects of purslane on bile duct ligation-induced hepatic fibrosis in albino rats

Ali, Sousou I.; Said, Mostafa M.; Hassan, Ehsan Khedre Mohammed

doi:10.1016/s1665-2681(19)31547-9

Cited by 27 publications

(10 citation statements)

References 25 publications

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“…TGF-β accelerates the activation of liver stellate cells and stimulates their conversion to myofibroblasts [48]. Consistent with our findings, Ali et al (2011) stated that PO had a prophylactic and therapeutic value on cholestasis-induced liver fibrosis by inhibiting oxidative stress, reducing the expression of profibrogenic cytokines, collagenolytic activity, and hepatic stellate cells activation [48]. In concordance with previous studies, ligation of the bile ducts significantly increased the expression of proinflammatory genes [49,50,51].…”

Section: Discussionsupporting

confidence: 91%

“…Also, TGF-β is the strongest proinflammatory factor that plays a vital role in initiating and maintaining fibrogenesis. TGF-β accelerates the activation of liver stellate cells and stimulates their conversion to myofibroblasts [48]. Consistent with our findings, Ali et al (2011) stated that PO had a prophylactic and therapeutic value on cholestasis-induced liver fibrosis by inhibiting oxidative stress, reducing the expression of profibrogenic cytokines, collagenolytic activity, and hepatic stellate cells activation [48].…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Portulaca oleracea methanolic extract attenuate bile duct ligation-induced acute liver injury through hepatoprotective and anti-inflammatory effects

Moslemi

Bahrami

Hosseini

et al. 2021

Heliyon

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Introduction: Cholestasis is a liver disease caused by a malfunction of the hepato-biliary system. Oxidative stress as a systemic complication is the main characteristic of cholestasis. The aim of this study was to evaluate the antiinflammatory and hepatoprotective effects of Portulaca oleracea (PO) methanolic extract on liver dysfunction and tissue damage induced by bile duct ligation (BDL) in rats. Materials and methods: Twenty-eight male Wistar rats were randomly divided into four groups: sham control (SC), BDL alone, SC plus 500 mg/kg methanolic extract of PO orally for 1 week, and BDL plus 500 mg/kg methanolic extract of PO orally for 1 week. After 1 week, the animals were anesthetized, and the liver and blood samples were taken from each animal. Biochemical parameters, oxidative stress biomarkers, histopathological changes, as well as the gene expression of IL-1, TNF-α, TGF-β, and α-SMA have been evaluated. Results:The methanolic extract of PO at a dose of 500 mg/kg significantly decreased the plasma levels of aminotransferases, alkaline phosphatase as compared to BDL group (P < 0.05), while it had no significant effect on the levels of oxidative stress markers in the hepatic tissue. The plasma level of malondialdehyde and ferricreducing antioxidant power were markedly elevated in the BDL group in comparison to SC group (P < 0.05), while treatment with PO significantly reduced these markers (P < 0.05). The administration of PO attenuated hydroxyproline content, bile duct proliferation, and inflammation score in the cholestatic liver in contrast to nontreated BDL rats (P < 0.05). Moreover, the methanolic extract of PO markedly declined the expression of TNF-α and TGF-β pro inflammatory genes in contrast to BDL rats. Conclusions: Taken together, our findings showed that PO attenuated liver injury by decreasing liver function tests, inflammation, and hydroxyproline content. As a result, it is suggested that PO can be applied in cholestatic liver damage as a therapeutic or adjuvant agent.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

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Portulaca oleracea methanolic extract attenuate bile duct ligation-induced acute liver injury through hepatoprotective and anti-inflammatory effects

Moslemi

Bahrami

Hosseini

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

“…Preventive effect of purslane on oxidative stress biomarkers such as SOD, CAT, GP, GSH, and MDA,[ 31 ] its effect on increased activities of CAT, SOD, and GPx,[ 32 ] reduction of lipid peroxidation levels, and increase in antioxidant enzyme activities[ 9 ] were reported which support the findings of the present study.…”

Section: Discussionsupporting

confidence: 87%

The effect of Portulaca oleracea and α-linolenic acid on oxidant/antioxidant biomarkers of human peripheral blood mononuclear cells

et al. 2018

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OBJECTIVES:Various pharmacological effects including antioxidant property of Portulaca oleracea L. were reported previously. In the present study, the effect of the extract of the plant and its constituent, α-linolenic acid (ALA), on oxidant and antioxidant markers of PHA/non-stimulated human mononuclear cells was evaluated.MATERIALS AND METHODS:The effect of 10, 40, and 160 μg/ml of P. oleracea and 5, 15, and 45 μg/ml of ALA or dexamethasone (0.1 mM) on nitric oxide (NO), malondialdehyde (MDA), total thiol (SH), superoxide dismutase (SOD), and catalase (CAT) in the supernatant of phytohemagglutinin-A (PHA)- and nonstimulated lymphocytes was examined (n = 6 for each group).RESULTS:In nonstimulated cells, dexamethasone, high concentration of the extract (160 μg/ml), and ALA (45 μg/ml) significantly increased thiol, CAT, and SOD values. Dexamethasone and high concentration of ALA significantly reduced MDA value (P < 0.01 to P < 0.001). However, the levels of NO and MDA due to dexamethasone and 160 μg/ml of the extract and 15 and 45 μg/ml of ALA treatment were also reduced in PHA-stimulated cells (P < 0.001 for all cases). Treatment of stimulated lymphocyte by dexamethasone and two higher concentrations of the extract and ALA also leads to increased levels of thiol, CAT, and SOD (P < 0.05 to P < 0.001).CONCLUSIONS:P. oleracea and ALA, as well as dexamethasone, decreased NO and MDA levels but increased antioxidant agents in human lymphocytes. These results suggest that P. oleracea and ALA may have therapeutic effect in diseases associated with enhancement of oxidation agents as an antioxidant agent.

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“…Also decreases the hepatic antioxidant activity. Conversely, by the administration of P. oleracea, all the disturbing biochemical parameters will return to normal [22]. P. oleracea have a promising role in the treatment of acute renal injury induced by nephrotoxins as cisplatin [23].…”

Section: Introductionmentioning

confidence: 99%

Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

et al. 2019

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Prophylactic and curative effects of purslane on bile duct ligation-induced hepatic fibrosis in albino rats

Cited by 27 publications

References 25 publications

Portulaca oleracea methanolic extract attenuate bile duct ligation-induced acute liver injury through hepatoprotective and anti-inflammatory effects

Portulaca oleracea methanolic extract attenuate bile duct ligation-induced acute liver injury through hepatoprotective and anti-inflammatory effects

The effect of Portulaca oleracea and α-linolenic acid on oxidant/antioxidant biomarkers of human peripheral blood mononuclear cells

Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

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