Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

Abstract

Graphical abstract

Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study

“…The activation of Kupffer cells and resident liver macrophages leads to the release of inflammatory cytokines and ROS, which are responsible for CdCl 2 -induced histopathological injuries [ 28 ]. Similar hepatic and renal histopathological damage has been reported in previous studies [ 8 , 29 , 30 ].…”

Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride

“…Cadmium exposure markedly decreased the activities of superoxide dismutase and catalase. This is consistent with the most recent finding of others [ [64] , [65] , [66] , [67] ]. Cadmium being a Fenton metal [ 7 , 8 ], may have bound to these enzymes, interacted with the covalent bonds of their amino acids residues and thus abruptly inhibited their activities.…”

“…MDA is a product of lipid peroxidation due to elevation of ROS in the physiological system and particularly in tissues [ 2 , 69 ]. Cd is also known to increase MDA in the physiological system [ 2 , 67 ]. Interestingly, hesperidin in this present study ameliorated all the oxidative dysregulations of both the enzymatic and non-enzymatic antioxidants caused by Cd exposure.…”

Chromolaena odorata flavonoids attenuate experimental nephropathy: Involvement of pro-inflammatory genes downregulation

“…CoF significantly downregulated TNF-α and MCP-1 and upregulated TNF-R and IL-10 as previously reported. Our findings here agree with previous report that flavonoid-rich preparations could inhibit production of renal TNF-α and MCP-1 following LPS treatment [ 42 ] and in cadmium toxicity [ 45 ].…”