Properties of osteoconductive biomaterials: Calcium phosphate cement with different ratios of platelet-rich plasma as identifiers

ObjectiveTo evaluate the use of subchondroplasty in the treatment of bone marrow lesions in an initial series of five cases.MethodsThe study included patients aged between 40 and 75 years old, with pain in the knee for at least six months, associated with high-signal MRI lesion on T2 sequences, on the tibia or femur. Patients were assessed using the visual analog pain scale and the KOOS score, one week before surgery and one, three, six, 12, and 24 weeks after the procedure. Subchondroplasty was performed with a technique developed for filling the area of the bone marrow lesion with a calcium phosphate bone substitute.ResultsThe filling was performed on the medial femoral condyle in four patients and medial tibial plateau in one case. The assessment by the KOOS score presented a preoperative average of 38.44 points and 62.7, 58.08, 57.92, 63.34, and 71.26 points with one, three, six, 12, and 24 weeks after surgery, respectively. In the evaluation by the VAS, the average was 7.8 points preoperatively and 2.8, 3, 2.8, 1.8, and 0.6 points over the same periods. All patients were able to ambulate without additional support, on the first day after the procedure. One patient had a minimal graft dislocation to the soft tissue, with local pain, which resolved completely after a week.ConclusionThe subchondroplasty technique provided significant improvements in the parameters of pain and functional capacity in the short-term assessment.

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“…For this function, biphasic calcium phosphate ceramics show good osteoinductive and osteoconductive results 23, 24…”

Section: Discussionmentioning

confidence: 99%

Subchondroplasty for treating bone marrow lesions in the knee – initial experience

Bonadio

Giglio

Helito

et al. 2017

Revista Brasileira de Ortopedia (English Edition)

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“…Finally, a scanning electron microscope (SEM, S3000 N, Hitachi, Japan) was used to observe the fiber distribution in the fractured composites. X-ray diffraction (XRD) and the attenuated total reflectanceFourier transform infrared (ATR-IR) absorption spectra of the PLA/CPC composites were performed to characterize the PLA/CPC composite specimens [17,18]. The results of XRD and FTIR are revealed in supplementary data.…”

Section: Test Methodsmentioning

confidence: 99%

Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications

et al. 2015

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An attempt to maintain the three-dimensional space into restorative sites through the conveniently pack porous fillers are general used strategy. Advancement in the manufacturing protective shells in the scaffolds, which would be filled with brittle ceramic grafts for the development of highly connective pores provides the approach to solve crack problem for generating the tissues. Therefore, multilayered braided and alkalized poly(lactic acid) (PLA) composites with calcium phosphate bone cement (CPC) were synthesized and compared. The PLA/CPC composites were divided into various groups according to a series of heat-treatment temperatures (100-190 °C) and periods (1-3 h) and then characterized. The effects of 24-h immersion on the strength decay resistance of the samples were compared. Results showed that the residual oil capped on the surfaces of alkalized PLA braid was removed, and the structure was unaltered. However, the reduced tensile stress of alkalized PLA braids was due to ester-group formation by hydrolysis. Mechanical test results of PLA/CPC composites showed that the strength significantly increased after heat treatment, except when the heating temperature was higher than the PLA melting point at approximately 160-170 °C. The degree of PLA after recrystallization became higher than that of unheated composites, thereby leading to reduced strength and toughness of the specimen. Braiding fibers of biodegradable PLA reinforced and toughened the structure particularly of the extra-brittle material of thin-sheet CPC after implantation.

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“…6). Numerous studies have confirmed that surfaces with higher hydrophilicity absorb more proteins [26], and these proteins have guiding effects on cell adhesion [27,28], which may be a reason for the superior cell attachment patterns on hydrophilic surfaces. To enhance the ability of the cell to adhere or migrate to surfaces, cells must possess high amounts of extensive focal adhesion proteins, which are generated by combining the integrin on pseudopodia with extracellular matrices, including collagen, elastin, laminin, and fibronectin.…”

Section: Cell Morphology On Varied Surfacesmentioning

confidence: 99%

“…The osteoconductive properties of calcium phosphates can direct the growth of bone cells into the pores, and the release of calcium and phosphorus ions results in enhanced cell mineralization. Researchers have indicated that the detachment of calcium phosphate ceramic-coated implants is occasionally caused by insufficient binding between the calcium phosphate salts and the implant rather than poor integration of the calcium phosphate salts and the bone [17,[24][25][26][27][28]. When force is applied to an implant, pressure is applied to the ductile Ti and brittle calcium phosphate coating, causing a break in the coating and detachment from the implant.…”

Section: Cell Morphology On Varied Surfacesmentioning

confidence: 99%

Effects of Ti surface treatments with silane and arginylglycylaspartic acid peptide on bone cell progenitors

2014

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Achieving optimal aesthetic appearance is a major objective in dental implant design, and the interaction between the materials and the bone cell progenitors is an important factor in the attainment of this objective. In this study, a novel concept was evaluated by varying the surface modifications on titanium (Ti). Different levels of roughness can be attained by machine grinding (M), sand blasting, and acid etching (SLA) of the samples. The behavior of bone cell progenitors (D1) on the surfaces of Ti disks with different surface modifications was investigated. The surfaces of M or SLA disks were silanized (MS or SLAS group) through treatment with silane/Gly-Arg-Gly-Asp-Ser (GRGDS) peptide (MSP or SLASP group) and anchored particles of tetracalcium phosphate (TTCP) on the specimen surfaces (SLA-TTCP group). Physicochemical analysis was performed by metallographic microscopy, scanning electron microscopy, and contact angle analysis. The proliferation and the quantitative alkaline phosphatase (ALP) production of D1 cells on the surface of different sample groups were determined. The SLASP group had a significantly larger D1 cell proliferation than the other groups after 4 and 7 d of incubation (p < 0.05). ALP expression was a very early marker of differentiation, and was the first indication of the increasing number of cells at 7 d of culture. Among the groups in the M substrate series (i.e., M, MS, and MSP) and in the SLA series (i.e., SLA, SLAS, and SLASP), the MSP and SLASP specimens exhibited superior differentiation abilities on respective cultures until day 7 and day 10. A high number of hydrophilic surfaces dominated cell proliferation in the early stage of cell attachment. However, factors affecting the pore structure and the surface morphology can improve cell proliferation and differentiation. According to analyses of proliferation and ALP expression of bone cell progenitors D1, the original SLA implant surface can be improved with surface treatment methods, such as silanization and treatment with graft GRGDS pentapeptide. These methods can be potential candidates for the promotion of bone growth.

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Properties of osteoconductive biomaterials: Calcium phosphate cement with different ratios of platelet-rich plasma as identifiers

Cited by 49 publications

References 38 publications

Subchondroplasty for treating bone marrow lesions in the knee – initial experience

Subchondroplasty for treating bone marrow lesions in the knee – initial experience

Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications

Effects of Ti surface treatments with silane and arginylglycylaspartic acid peptide on bone cell progenitors

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