Properties of ibuprofen ion-selective electrodes based on the ion pair complex of tetraoctylammonium cation

Abstract

), really long lifetime (12 months), dependence of the electrode potential on pH (5.5 -9.0), reproducibility of potential (0.6-1.2 mV) and selectivity coefficients in relation to some organic and inorganic anions. The electrodes were applied for the determination of ibuprofen in tablets by the calibration curve method and the standard addition method. © Versita Sp. z o.o.

Development of a second type electrode based on the silver/silver ibuprofenate pair for ibuprofen quantification in pharmaceutical samples

“…14 However, potentiometry has been the most explored technique for quantifying ibuprofen, due to its good sensitivity, high selectivity, better precision and accuracy, electrodes capable of being miniaturized, easily built, low cost and no destruction of the sample; 15,16 although, just a few potentiometric sensors have been reported for the determination and quantification of ibuprofen. Sensors based in membranes containing ion-exchangers, 17 cyclodextrins, 18 ion pair complexes, 19 and ionophores 20 have been reported for the quantification of ibuprofen with good results, although, the construction of the selective membranes is complicated, expensive, and sometimes responses are attained after prolonged times.…”

“…[16][17][18][19] Compared with other second type potentiometric electrodes, the Ag/AgIbu electrode does not comprise toxic substances like mercury. 22 …”

Potentiometric Electronic Tongue for Taste Assessment of Ibuprofen Based Pharmaceuticals

“…Ibuprofen (IBU) (Figure ) having a bitter taste is an important API in the products from Winthrop Arzneimittel, labelled Ibuflam 4 %. Generally, IBU is one most effective drug for temporary treatment of children and teenagers migraine headaches and causes less undesirable effects than other non‐steroidal antiinflammatory drugs .…”

“…Moreover, the numerous specific and non‐specific ionophores , ionic additives, plasticizers and matrixes give the greatest possibilities to develop the potentiometric array for taste evaluation of IBU containing pharmaceutical formulations. However, a major group of potentiometric sensors from the mentioned publications has been proposed for IBU quantification either in model solutions or tablets . Therefore, the development of the potentiometric ET for taste assessment of the liquid oral formulations could be challenging and bring new benefits.…”

“…It has to be noted that the application of Principal Component Analysis (PCA) has been growing steadily and contributing successfully at processing of electrochemical data obtained with ET . PCA coupled with electrochemical analysis allowed to predict taste of unknown drug substance , to evaluate the effectiveness of various masking agents in orally disintegrating tablets , to simplify the development of a taste masked generic formulation , to detect microencapsulation effect of APIs affecting taste , to detect single substances as well as complex mixtures .…”