Application of PVC in Construction of Ion‐Selective Electrodes for Pharmaceutical Analysis: A Review of Polymer Electrodes for Nonsteroidal, Anti‐Inflammatory Drugs

Lenik, Joanna

doi:10.1002/9781119041412.ch8

Cited by 5 publications

(5 citation statements)

References 61 publications

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“…According to the international classification, household floor coverings are distinguished depending on the level of their resistance to abrasion, which is indicated by two numbers -from 21 to 43. The first digit indicates the type of room (2 -domestic/residential, 3 -public, 4 -industrial), and the second is the load on the floor depending on the level of attendance (1 -low, 2 -medium, 3 -high, 4 -very high) [7,8].…”

Section: Methodsmentioning

confidence: 99%

“…In our previous studies, the effect of silicon dioxide modification on flammability, thermal stability, smoke formation of PVC [2] as well as the properties of PVC [3] materials in the presence of various fillers [4] were studied. The obtained data [5] was however not enough to describe the interaction mechanism of industrial flame retardants based on Sb 2 O 3 [6] in polymer PVC linoleum compositions [7].…”

mentioning

confidence: 99%

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Wpływ dodatków uniepalniających na bazie Sb2O3 na palność PVC

Kurta,

Shevchenko А.,

Khatsevich

et al. 2023

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Zbadano handlowe dodatki uniepalniające na bazie Sb2O3. Wykazują one działanie akceptorowe, termostabilizujące i uniepalniające na linoleum z PVC. Na podstawie spektroskopii IR, analizy DTA, dyfrakcji oraz analizy fluorescencji rentgenowskiej stwierdzono, że jedna z próbek zawiera 100% Sb2O3, natomiast pozostałe zawierają mikrokrystaliczny CaCO3 (50-95%) oraz inne związki np. chloroorganiczne i węglowodory. Mechanizm uniepalniania linoleum z PVC polega na synergicznym działaniu Sb2O3 i CaСО3 poprzez wiązanie gazowego chlorowodoru powstającego podczas spalania i rozkładu termicznego PVC.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Wpływ dodatków uniepalniających na bazie Sb2O3 na palność PVC

Kurta,

Shevchenko А.,

Khatsevich

et al. 2023

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“…This paper describes Ag/AgCl solid contact electrodes for chlorhexidine determination. The construction of the sensor was simple and low-cost and was published in earlier papers and in the chapter of a book [28][29][30]. The novelty of this work consisted of the incorporation of other active substances belonging to macrocyclic compounds, which improved some parameters of the developed electrodes.…”

Section: Introductionmentioning

confidence: 99%

A Novel Polymeric Membrane Sensor for Chlorhexidine Determination

Lenik,

Sokal

2023

Sensors

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In the present work, potentiometric sensors with polymer membranes used for chlorhexidine (CHXD) determination were developed. The polymer membranes were plasticized with bis(2-ethylheksyl)sebacate (DOS) or 2-nitrophenyloctyl ether (o-NPOE). The active compounds used in the membrane were cyclodextrins, crown ethers, and ion exchangers. The best-constructed electrode was based on neutral heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin with lipophilic salt (KTpClBP)—potassium tetrakis(4-chlorophenyl) borate—dissolved in plasticizer, DOS. The presented electrode is characterized by an average cationic slope of 30.9 ± 2.9 mV decade−1 within a linear range of 1 × 10−6 to 1 × 10−3 mol × L−1, while the value of the correlation coefficient is 0.9970 ± 0.0026. The response time was about 5 s when increasing the sample concentration and about 10 s when diluting the sample. The electrode potential is independent of the pH within a range of 4.0–9.5. The polymeric membrane sensor was successfully applied for assays of chlorhexidine digluconate in pure samples and pharmaceutical samples. The relative error from three replicate measurements was determined to be 1.1%. and the accuracy was RSD = 0.3–1.1%.

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“…It is well known that the NSAIDs, by their mechanism of action, are decreasing the pain which can appear in rheumatic diseases when are administered orally repeatedly, but the gastric side effects can also occur [12,22]. Recent studies showed that over 30 millions of people are using substances from this class of drugs, 40 % being over 65 years old [6,14]. Indomethacin (IND) belongs to the NSAIDs class often used in inflammatory pathologies.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Release Performance of Indomethacin From Transdermal Therapeutic Systems

Antonoaea¹

2020

FARMACIA

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By their advantages, transdermal therapeutic systems (TTSs) represent an alternative to the conventional pharmaceutical forms. In this study, 3 formulations of TTSs with indomethacin (IND) were developed, which were subjected to analysis by model-independent (by calculation of the f1 and f2 factors; linearization by simple regression), respectively model-dependent methods (modelling with Higuchi function). Release evaluation of the IND was performed using the Franz diffusion cell method through a synthetic or biological membrane, at pH 5.5 and pH 7.4. The obtained results showed that although differences were observed between the analysed release profiles, at an evaluation of the f2 factors there were observed similarities in the shapes of the release curves. By simple linear regression it was determined the diffusion flux through the membranes, which varied depending on the pH and on the type of membrane: 0.749-80.270 g/cm 2 h. The R² < 1 values denote the influence of the ingredients in the IND release. Under certain experimental conditions, the IND3 formulation maintains the steady state for 28 hours at pH 5.5, respectively 12 hours at pH 7.4. Rezumat Datorită avantajelor pe care le conferă, sistemele terapeutice transdermice (STT) reprezintă o alternativă la formele farmaceutice convenţionale. În acest studiu s-au dezvoltat 3 formulări de STT cu indometacin (IND), care au fost supuse analizei prin metode model-independente (calcularea factorilor f1 și f2; liniarizarea prin regresie simplă), respectiv modeldependente (modelare cu funcția Higuchi). Evaluarea cedării IND s-a realizat prin metoda cu celula difuzimetrică Franz, studiul efectuându-se prin membrană sintetică sau biologică, la pH 5,5 și pH 7,4. Rezultatele obținute au arătat că deși au fost observate diferenţe între curbele de cedare analizate, la o evaluare a factorilor f2 s-a observat o similaritate în alura curbelor de cedare. Prin liniarizarea prin regresie simplă s-a determinat fluxul prin membrane, care a variat în funcţie de pH şi de tipul membranei: 0,749-80,270 g/cm 2 h. Valorile R² < 1 denotă influenţa ingredientelor în cedarea IND. În anumite condiții experimentale, formularea IND3 menține starea de echilibru 28 ore la pH 5,5, respectiv 12 ore la pH 7,4.

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Application of PVC in Construction of Ion‐Selective Electrodes for Pharmaceutical Analysis: A Review of Polymer Electrodes for Nonsteroidal, Anti‐Inflammatory Drugs

Cited by 5 publications

References 61 publications

Wpływ dodatków uniepalniających na bazie Sb2O3 na palność PVC

Wpływ dodatków uniepalniających na bazie Sb2O3 na palność PVC

A Novel Polymeric Membrane Sensor for Chlorhexidine Determination

Comparative Analysis of the Release Performance of Indomethacin From Transdermal Therapeutic Systems

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