Properties and therapeutic potential of solid lipid nanoparticles and nanostructured lipid carriers as promising colloidal drug delivery systems

Özdemir, Samet; Çelik, Burak; Üner, Melike

doi:10.1016/b978-0-12-816913-1.00015-5

Cited by 17 publications

(12 citation statements)

References 201 publications

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“…Drug delivery systems using NPs have been developed in recent decades to solve the major problems of ocular drug administration, resulting in a safe and effective system that delivers the medicine to the appropriate region (Qamar et al, 2019). Development of various nanotechnology-based nanomedicines with different novel systems, including liposomes (Urquhart and Eriksen, 2019), solid lipid NPs (Patil et al, 2019), nanostructured lipid carriers (NLA) (Ozdemir et al, 2019), dendrimers (Villanueva et al, 2016), polymeric NPs (Mandal et al, 2017), inorganic NPs, microemulsion, nanosuspension, nanoemulsion, and noisome, which results in increased retention time, the solubility of hydrophobic drugs, bioavailability, enhanced drug penetration, and target specific sites. The encapsulation of the desired medicine in a nanoparticle also helps to protect it from degradation (Qamar et al, 2019).…”

Section: Synthesis and Characteristics Of Nanoparticlesmentioning

confidence: 99%

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Merlin

2022

Front. Genet.

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Nanoparticles (NPs) are differing in particle size, charge, shape, and compatibility of targeting ligands, which are linked to improved pharmacologic characteristics, targetability, and bioavailability. Researchers are now tasked with developing a solution for enhanced renal treatment that is free of side effects and delivers the medicine to the active spot. A growing number of nano-based medication delivery devices are being used to treat renal disorders. Kidney disease management and treatment are currently causing a substantial global burden. Renal problems are multistep processes involving the accumulation of a wide range of molecular and genetic alterations that have been related to a variety of kidney diseases. Renal filtration is a key channel for drug elimination in the kidney, as well as a burgeoning topic of nanomedicine. Although the use of nanotechnology in the treatment of renal illnesses is still in its early phases, it offers a lot of potentials. In this review, we summarized the properties of the kidney and characteristics of drug delivery systems, which affect a drug’s ability should focus on the kidney and highlight the possibilities, problems, and opportunities.

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Section: Synthesis and Characteristics Of Nanoparticlesmentioning

confidence: 99%

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Merlin

2022

Front. Genet.

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“…This is because they are suitable to hold a high payload of both soluble and insoluble actives; their size range is flexible (50–1,000 nm); greater stability compared to liposomal and polymeric nanoparticles; and are safe within the body even for an extended period due to their low toxicity. The SLN can be made to have a drug enriched core surrounded by a solid lipid shell or the shell could contain the drug and the core be made of solid lipids (Özdemir et al, 2019; Sadegh Malvajerd et al, 2019). For these reasons SLN are very suitable nanocarriers for drug targeting such as for penetrating the BBB (Sadegh Malvajerd et al, 2019).…”

Section: Ultrasound Interaction With Nanoparticlesmentioning

confidence: 99%

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Tharkar

Varanasi

Wong

et al. 2019

Front. Bioeng. Biotechnol.

147

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While ultrasound is most widely known for its use in diagnostic imaging, the energy carried by ultrasound waves can be utilized to influence cell function and drug delivery. Consequently, our ability to use ultrasound energy at a given intensity unlocks the opportunity to use the ultrasound for therapeutic applications. Indeed, in the last decade ultrasound-based therapies have emerged with promising treatment modalities for several medical conditions. More recently, ultrasound in combination with nanomedicines, i.e., nanoparticles, has been shown to have substantial potential to enhance the efficacy of many treatments including cancer, Alzheimer disease or osteoarthritis. The concept of ultrasound combined with drug delivery is still in its infancy and more research is needed to unfold the mechanisms and interactions of ultrasound with different nanoparticles types and with various cell types. Here we present the state-of-art in ultrasound and ultrasound-assisted drug delivery with a particular focus on cancer treatments. Notably, this review discusses the application of high intensity focus ultrasound for non-invasive tumor ablation and immunomodulatory effects of ultrasound, as well as the efficacy of nanoparticle-enhanced ultrasound therapies for different medical conditions. Furthermore, this review presents safety considerations related to ultrasound technology and gives recommendations in the context of system design and operation.

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“…FT-IR test is intended to determine the compatibility between the materials used [11,12]. This test is carried out by analyzing the active substance Adapalen, Precirol® ATO5 solid lipid, and a mixture of Precirol® ATO5-Adapalen solid lipid.…”

Section: Ftir Testingmentioning

confidence: 99%

Development and Characterization of Precirol Ato 88 Base in Nanostructured Lipid Carriers (Nlc) Formulation With the Probe Sonication Method

et al. 2021

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Objective: Adapalene is a medicinal ingredient that can be used to treat acne. Adapalene has a Log P value of 8.6 and has high lipophilic and low solubility in water and is potentially degraded. Adapalene NLC can increase biphasic drug penetration at low doses but has good reactivity and provides occlusive properties that can increase skin hydration, thereby accelerating acne treatment. Methods: Forming Adapalene NLC using the method of heat homogenization followed by ultrasonication probe. The NLC formulas used were Precirol ATO5 ®4.0%, Myritol ® 2%, Cremophor RH 40 1%, Plantacare 1%, Tegocare 1%, and Adapalene 0.3%. Following that is the characterization of particle size, polydispersity index, zeta potential, efficiency entrapment. Results: The results showed the measurement of particle size with a range (150-318 nm), index polydispersion showed (0.12-0.36) and zeta potential (-26)-(-60 mV) and efficient entrapment testing showed results (84-98 %). In the TEM morphological evaluation of images showing spherical and evenly distributed forms, this is in line with the results of the adapalene NLC characterization. Conclusion: These results suggest that NLC containing adapalene showed excellent result.

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Properties and therapeutic potential of solid lipid nanoparticles and nanostructured lipid carriers as promising colloidal drug delivery systems

Cited by 17 publications

References 201 publications

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Development and Characterization of Precirol Ato 88 Base in Nanostructured Lipid Carriers (Nlc) Formulation With the Probe Sonication Method

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