Properties and Stability of Solid Lipid Particle Dispersions Based on Canola Stearin and Poloxamer 188

Abstract

Solid lipid particles (SLP) are one strategy for encapsulating lipophilic molecules, including for controlled release and enhanced bioavailability applications. SLP based on fully hydrogenated canola stearin (CaSt, 5, 10, 20, and 30 wt%) and the non-ionic surfactant Poloxamer 188 (P188, 0.0, 0.5, 1.0, 2.5, 5.0 and 10.0 wt%) were produced by high pressure melt homogenization using a microfluidizer. Spherical particles in the region of 140 nm were formed, depending on compostion and processing parameters. Surfactant concentration and pressure had a significant influence on particle diameter (P \ 0.05), although number of homogenization cycles did not (P [ 0.05). A maximum surfactant surface load of approximately 4 mg m -2 was observed and, at or above 2.5% P188, excess surfactant was present in the continuous phase after production. P188 had the effect of decreasing particle size and facilitating transitions from the a to the b polymorph (P \ 0.05) both through surface nucleation and size reduction effects. A stability study of the 10% CaSt SLP with 0.0, 1.0, or 5.0% P188 revealed particle growth for the 0.0 and 1.0% P188 SLP, especially at 20 versus 4°C, but no changes in the 5.0% P188 SLP, which were exclusively in the b form, at both temperatures for up to 240 days.

Digestibility and β-carotene release from lipid nanodispersions depend on dispersed phase crystallinity and interfacial properties

“…An empty pan served as the reference, instrument calibration was performed using indium and the instrument software, TA Universal Analysis, (TA instruments, Mississauga) was used to determine peak melting temperatures which were designated as a, b 0 , or b based on previous reports. 34 Polymorphic assignments were confirmed by X-ray diffraction (XRD), as previously reported. 34 …”

Determining drug release rates of hydrophobic compounds from nanocarriers

“…Increasing the time further resulted the additional presence of 200 μm aggregates. This is evidence of over processing of particles, which results in aggregation or coalescence if newly formed particles are not adequately stabilized by surfactant or emulsifier [19].…”

Evaluation of the Influence of Process Parameters on the Properties of Resveratrol-Loaded NLC Using 22 Full Factorial Design

“…In Poloxamer ® 188, the hydrophobic polypropylene oxide chains are adsorbed onto the particle surface as the “anchor chain”, while the hydrophilic polyethylene oxide chains are pulled out from the surface to the aqueous medium, thereby creating a stabilizer layer [45]. In addition, Poloxamer ® 188 exhibits low toxicity, can control release and targeted delivery applications, and is stable at high temperatures [46]. Tween ® 80 is a polyethoxylated sorbitan and oleic acid derivative that has high surface activity and low toxicity [39].…”