Prooxidant–antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma

Κολιάκος, Γεώργιος; Befani, Christina; Mikropoulos, Dimitrios G.; Ziakas, Nikolaos; Konstas, A. G. P.

doi:10.1007/s00417-008-0871-y

Cited by 48 publications

(36 citation statements)

References 36 publications

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“…17 The difference between the study of Koliakos et al and ours might be due to the differences in life style, dietary habits and genetic background of the subjects in the two studies. 17 Hence, in another Turkish study, Yılmaz et al reported nonsignificantly lower catalase activities in PEX patients compared to controls, similar to our study. 5 In addition to these studies on PEX, catalase activity was also measured in other disorders of the eye.…”

Section: Discussioncontrasting

confidence: 47%

“…Koliakos et al found that catalase activity in the aqueous humor from PEX (10.1±4.5 U/ml) and PEG (12.2±6 U/ml) patients was significantly lower than that measured in the normal aqueous humor (14.6±1.9 U/ml). 17 Similarly, a significantly lower serum catalase activity was found in PEX (103±21.4 U/ml) and PEG (116±38 U/ml) patients compared to the controls (189.6±84.3 U/ml). 17 The difference between the study of Koliakos et al and ours might be due to the differences in life style, dietary habits and genetic background of the subjects in the two studies.…”

Section: Discussionmentioning

confidence: 96%

“…17 Similarly, a significantly lower serum catalase activity was found in PEX (103±21.4 U/ml) and PEG (116±38 U/ml) patients compared to the controls (189.6±84.3 U/ml). 17 The difference between the study of Koliakos et al and ours might be due to the differences in life style, dietary habits and genetic background of the subjects in the two studies. 17 Hence, in another Turkish study, Yılmaz et al reported nonsignificantly lower catalase activities in PEX patients compared to controls, similar to our study.…”

Section: Discussionmentioning

confidence: 96%

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Ceruloplasmin and Catalase Activites in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Mumcuoğlu¹,

Demirdöğen²,

Ceylan³

et al. 2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Pseudoexfoliation syndrome (PEX) is an age-related systemic disorder primarily with ocular manifestations. PEX is considered as the most common identifiable cause of glaucoma (pseudoexfoliation glaucoma, PEG) and loss of vision. Oxidative stress was suggested to be involved in the pathogenesis of PEX and PEG. Catalase is an antioxidant enzyme which catalyzes decomposition of hydrogen peroxide to water and oxygen. Ceruloplasmin was reported to have antioxidant functions, as well as pro-oxidant activity. This study has aimed to determine whether ceruloplasmin and catalase activities have a role in the development of PEX and/or PEG. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Ceruloplasmin and catalase activities were determined in serum samples of 32 cases of PEX, 30 cases of PEG and 32 control subjects using spectrophotometric methods. R Re es su ul lt ts s: : Ceruloplasmin activities of PEX patients (32.94±16.36 U/L) and PEG patients (29.98±13.15 U/L) were similar and slightly lower than those of controls (35.22±21.32 U/L). However, the differences were not statistically significant. Catalase activites were found to be 61.96±33.95 U/L and 60.44±50.84 U/L in PEX and PEG patients, respectively. Controls had slightly, but insignificantly, higher catalase activities (64.98±58.14 U/L). C Co on nc cl lu us si io on n: : Neither catalase nor ceruloplasmin activities are significantly related with PEX or PEG in the studied Turkish population. As the mean age of populations keeps increasing, PEX may become more common in the future. Therefore, further studies are needed to decipher the pathophysiology of this important disorder.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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Ceruloplasmin and Catalase Activites in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Mumcuoğlu¹,

Demirdöğen²,

Ceylan³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…In our study, we aimed to explore this phenomenon by comparing parameters related to oxidative balance in NTG and PEXG. The oxidant/antioxidant parameters in PEX and PEXG patients has been studied extensively and OS markers were found to have risen, while antioxidants have diminished, resulting in an oxidative balance in favor of oxidants [9][10][11][12][13]. There are fewer studies on NTG, but an increase in OS has been associated with it nonetheless [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…Pseudoexfoliation glaucoma (PEXG) is also associated with OS, in which abnormal extracellular fibrillar material is accumulated in the eye, obstructing humor drainage [8]. PEX syndrome (PEX) is, in fact, an age-related systemic disorder of the extracellular matrix, also observed in the vascular system and various organs [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

Yılmaz¹,

Çoban²,

Bayındır³

et al. 2015

Bosn J of Basic Med Sci

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This study entailed a cross-examination of oxidant/antioxidant balance, high-density lipoprotein (HDL)-linked paraoxonase 1 (PON1) phenotypes, and levels of serum routine lipids among patients with normal tension glaucoma (NTG) or pseudoexfoliative glaucoma (PEXG) compared with healthy control groups. We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. The study included 32 patients with NTG, 31 patients with PEXG, and 40 control subjects. Levels of PON1 and arylesterase enzymatic activity, total oxidant status (TOS), and total antioxidant status were measured by spectrophotometry and OS indexes (OSI) were calculated. The phenotype distribution of PON1 was determined using the dual substrate method. Blood serum levels of HDL, low-density lipoprotein, total cholesterol (TC), and triglyceride (TG) were measured. The TOS and OSI values in the NTG group were significantly higher compared with the other groups (both p < 0.01). The phenotype distribution found in the glaucoma and control groups were NTG: QQ, 59.4%; QR, 37.5%; RR, 3.1%; PEXG: QQ, 45.1%; QR, 48.4%; RR, 6.5%; and in the control group: QQ, 42.5%; QR, 50.0%; RR, 7.5%. Serum TC levels were significantly higher than the control in both NTG and PEXG groups, whereas TG was significantly higher in NTG only (p < 0.01 and p < 0.02, respectively). Hyperlipidemia, OS and variations in phenotype distribution of PON1 may play a role in the pathogenesis of different types of glaucoma.

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Diagnose und Therapie des Pseudoexfoliationsglaukoms

Jünemann

2012

Ophthalmologe

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Pseudoexfoliation (PEX) glaucoma is the most frequent and most important type of secondary glaucoma, accounting for approximately 25% of open angle glaucoma worldwide and currently representing the most common identifiable cause of glaucoma overall. Due to high intraocular pressure levels, marked diurnal pressure fluctuations and spikes, and rapid optic nerve damage and visual field loss, PEX glaucoma represents a relatively severe and progressive type of glaucoma. Therefore, hard and fast lowering of intraocular pressure is necessary. Fixed combinations in medical therapy and early glaucoma surgery are recommended. When considering a surgical procedure (e.g. selective laser trabeculoplasty, bleb-dependent or bleb-independent surgery) the timing of cataract surgery plays a major role. Pathogenesis, clinical characteristics and therapeutic aspects of PEX glaucoma are described in the following article.

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Prooxidant–antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma

Abstract: These findings suggest that in XFS oxidative stress is counterbalanced in the aqueous, whereas the development of XFG is accompanied by a disruption of this balance in favour of oxidants.

Cited by 48 publications

References 36 publications

Ceruloplasmin and Catalase Activites in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Ceruloplasmin and Catalase Activites in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Higher serum lipids and oxidative stress in patients with normal tension glaucoma, but not pseudoexfoliative glaucoma

Diagnose und Therapie des Pseudoexfoliationsglaukoms

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