2016
DOI: 10.2147/ijn.s109552
|View full text |Cite
|
Sign up to set email alerts
|

Promotion of the transdermal delivery of protein drugs by <em>N</em>-trimethyl chitosan nanoparticles combined with polypropylene electret

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
6
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 19 publications
(11 citation statements)
references
References 40 publications
2
6
0
Order By: Relevance
“…Similar results were obtained in a study by Murthy et al which showed that Teflon electrets were unable to enhance delivery of high molecular weight drugs [162]. To this regard, a novel approach has been suggested by Tu et al to address the issue of delivering high molecular weight drugs [158]. The study shows that using drug loaded N-trimethyl chitosan nanoparticles (TMC NPs) in combination with PP electret films enhances transdermal delivery of protein drugs, thanks in part to the mucoadhesive ability of chitosan to be absorbed across mucosa epithelia.…”
Section: Electret Mediated Delivery Of Drugssupporting
confidence: 73%
See 2 more Smart Citations
“…Similar results were obtained in a study by Murthy et al which showed that Teflon electrets were unable to enhance delivery of high molecular weight drugs [162]. To this regard, a novel approach has been suggested by Tu et al to address the issue of delivering high molecular weight drugs [158]. The study shows that using drug loaded N-trimethyl chitosan nanoparticles (TMC NPs) in combination with PP electret films enhances transdermal delivery of protein drugs, thanks in part to the mucoadhesive ability of chitosan to be absorbed across mucosa epithelia.…”
Section: Electret Mediated Delivery Of Drugssupporting
confidence: 73%
“…TDD, a process of administrating drugs/therapeutic agents through intact skin) [152,153]. for different types of drug formulations [158,160,161]. In one of the studies, it was observed that electrets of various surface potentials alone enhanced the permeation of meloxicam, a low molecular weight drug (< 1 kDa), more than the chemical enhancer on its own [161].…”
Section: Electret Mediated Delivery Of Drugsmentioning
confidence: 99%
See 1 more Smart Citation
“…Chitosan possesses numerous benefits including its biodegradability, bioavailability, and high safety profile [ 18 , 19 ]. Most importantly, CS exhibits permeability enhancing properties due to its cationic nature which enhances skin penetration through interacting with the oppositely charged SC, loosening the tight junction, thus enhancing penetration to subcutaneous adipocytes [ 20 , 21 ]. CS nanoparticles are commonly assembled via ionic crosslinking between positive amino groups present in the CS chains with an oppositely charged agent such as sodium tripolyphosphate (TPP)—a multivalent non-toxic anion (TPP) [ 22 , 23 , 24 , 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…The advantage of the low concentration requirement of chitosan along with body temperature-activated rheology proved chitosan as the cost-effective polymer for its use. As a new multiplatform for dermal use, Tu et al [91] combined the use of N -trimethyl chitosan nanoparticles (TMCNPs) with polypropylene electret to promote the dermal delivery of protein drugs. Electret is a dielectric material that can hold onto its electric charge for a long time.…”
Section: Diversity Of Chitosan-based Local Drug Deliverymentioning
confidence: 99%