Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon, Biranche; Magaz, Adrián; Balint, Richard; Blaker, Jonny J.; Cartmell, Sarah H.

doi:10.1016/j.addr.2017.12.012

Cited by 140 publications

(130 citation statements)

References 303 publications

(447 reference statements)

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“…The electroactive biomaterials are smart systems, which are able to deliver electrical stimulation (ES) to the surrounding media to impart an effect on the behavior of biological systems [1,2]. In particular, these biomaterials take advantage of the effect of a direct current (DC) or an electrical field on both cell proliferation and differentiation, stimulating, for instance, the regeneration of muscles, organs, and/or bones [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

et al. 2020

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Applying electrical stimulation (ES) could affect different cellular mechanisms, thereby producing a bactericidal effect and an increase in human cell viability. Despite its relevance, this bioelectric effect has been barely reported in percolated conductive biopolymers. In this context, electroactive polycaprolactone (PCL) scaffolds with conductive Thermally Reduced Graphene Oxide (TrGO) nanoparticles were obtained by a 3D printing method. Under direct current (DC) along the percolated scaffolds, a strong antibacterial effect was observed, which completely eradicated S. aureus on the surface of scaffolds. Notably, the same ES regime also produced a four-fold increase in the viability of human mesenchymal stem cells attached to the 3D conductive PCL/TrGO scaffold compared with the pure PCL scaffold. These results have widened the design of novel electroactive composite polymers that could both eliminate the bacteria adhered to the scaffold and increase human cell viability, which have great potential in tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

et al. 2020

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“…Their molecular structures can be modified either prior to or after polymerization, and they often show good biocompatibility and low toxicity. Thus, ICPs are under active investigation for diverse applications in biomedical engineering [5] including biosensing [6], cellular interfacing [7], controlled drug release [8], and tissue engineering [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and 3D Printing of Conducting Alginate–Polypyrrole Ionomers

Wright

Molino

Chung

et al. 2020

Gels

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Hydrogels composed of calcium cross-linked alginate are under investigation as bioinks for tissue engineering scaffolds due to their variable viscoelasticity, biocompatibility, and erodibility. Here, pyrrole was oxidatively polymerized in the presence of sodium alginate solutions to form ionomeric composites of various compositions. The IR spectroscopy shows that mild base is required to prevent the oxidant from attacking the alginate during the polymerization reaction. The resulting composites were isolated as dried thin films or cross-linked hydrogels and aerogels. The products were characterized by elemental analysis to determine polypyrrole incorporation, electrical conductivity measurements, and by SEM to determine changes in morphology or large-scale phase separation. Polypyrrole incorporation of up to twice the alginate (monomer versus monomer) provided materials amenable to 3D extrusion printing. The PC12 neuronal cells adhered and proliferated on the composites, demonstrating their biocompatibility and potential for tissue engineering applications.

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“…CPHs are nontoxic and compatible with living tissue or cells [182], [109], [166], [57]. CPH properties offer their use in various interesting fields, particularly in biomedicine and energy storage, and are among the most promising trends in materials science, which have been and are still widely studied [183], [149], [150], [151], [152], [138]. Some common features of CPHs are discussed below, among which the sub-standard is their inhomogeneity.…”

Section: Conducting Polymer Hydrogelsmentioning

confidence: 99%

“…The family of electroactive biomaterials is considered a new generation of smart materials that allow the direct delivery of electrical signals by converting their chemical, electrical and physical properties ( Fig. 8A) [183]. These biomaterials include CPs, piezoelectrics, photovoltaic materials, and electrets.…”

Section: Drug Delivery Systems Containing Icpsmentioning

confidence: 99%

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Tomczykowa

Płońska‐Brzezińska

2019

Preprint

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This review is focused on current state-of-the-art research on electroactive-based materials and their synthesis, as well as their physicochemical and biological properties. Special attention is paid to pristine intrinsically conducting polymers (ICPs) and their composites with other organic and inorganic components, well-defined micro- and nanostructures, and enhanced surface areas compared with those of conventionally prepared ICPs. Hydrogels, due to their defined porous structures and being filled with aqueous solution, offer the ability to increase the amount of immobilized chemical, biological or biochemical molecules. When other components are incorporated into ICPs, the materials form composites; in this particular case, they form conductive composites. The design and synthesis of conductive composites result in the inheritance of the advantages of each component and offer new features because of the synergistic effects between the components. The resulting structures of ICPs, conducting polymer hydrogels and their composites, as well as the unusual physicochemical properties, biocompatibility and multi-functionality of these materials, facilitate their bioapplications. The synergistic effects between constituents have made these materials particularly attractive as sensing elements for biological agents, and they also enable the immobilization of bioreceptors such as enzymes, antigen–antibodies, and nucleic acids onto their surfaces for the detection of an array of biological agents. Currently, these materials have unlimited applicability in biomedicine. In this review, we have limited discussion to three areas in which it seems that the use of ICPs and materials, including their different forms, are particularly interesting, namely, biosensors, delivery of drugs and tissue engineering.

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Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Cited by 140 publications

References 303 publications

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

Electroactive 3D Printed Scaffolds Based on Percolated Composites of Polycaprolactone with Thermally Reduced Graphene Oxide for Antibacterial and Tissue Engineering Applications

Synthesis and 3D Printing of Conducting Alginate–Polypyrrole Ionomers

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

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