Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

Association Between Postoperative Long-Term Heart Rate Variability and Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Prospective Cohort Study

“…While life expectancy is rising, the health span has not kept up with it (Partridge et al, 2018). The aging process has been linked to the occurrence of chronic diseases and functional impairments, including frailty and metabolic and neurodegenerative diseases (Niccoli and Partridge, 2012;Rivero-Segura et al, 2020). Except for old-old population with hip fractures, a considerable part of the patients who underwent orthopedic surgery were youngold patients who suffered from arthritis.…”

“…As a common chronic disease in the elderly, an European cross-sectional survey indicates that nearly 50% of elderly patients with symptomatic knee osteoarthritis show fragility (Salaffi et al, 2020). Particularly, fragility is not only a reflection of biologic rather than chronologic age but also an important predisposing factor of delirium (Bersani et al, 2020;Rivero-Segura et al, 2020;Susano et al, 2020).…”

Precision Medicine and Precision Nursing: The Era of Biomarkers and Precision Health

“…Cardiovascular disease, cancer and, more in general, chronic diseases, that are also linked to human aging, have been considered optimal fields to study the role of several biomarkers. 20 …”

“…Cardiovascular disease, cancer and, more in general, chronic diseases, that are also linked to human aging, have been considered optimal fields to study the role of several biomarkers. 20 Considering the aging process, we can follow consecutive clinical manifestations related to the same pathological process. For example, the studies by Serra et al showed how varicocele in a patient can predict the onset of inguinal hernia and chronic venous disease (CVD) in a more advanced age relating also this progression with extracellular matrix (ECM) alterations due to abnormal matrix metalloproteinase (MMP) activity that can even be measured in the blood as well as pathological tissues.…”

Physical Frailty: A Biological Marker of Aging?

“…Clinical studies are now ongoing looking at the effect of metformin as a retardant of the aging process (23). In addition, there is evidence that vaccinations such as influenza and diphtheria/ tetanus may lower the risk of dementia by modulating the T-cell immune response (24).…”