Physical Frailty: A Biological Marker of Aging?

Morley, John E.

doi:10.1007/s12603-020-1531-0

Cited by 4 publications

(2 citation statements)

References 49 publications

(46 reference statements)

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“…Intrinsic capacity is defined as the resilience that an individual has to overcome a variety of environmental, physical and psychological factors. When a person declines at a more rapid rate than the age-related decline in intrinsic capacity, they are said to be exhibiting frailty [27]. Physical frailty was operationalized by Fried et al [28], who defined it as being the presence of three or more of the following: fatigue, weight loss, weakness, slow walking gait and limited physical activity.…”

Section: Discussionmentioning

confidence: 99%

A prospective cohort study of the risk factors for new falls and fragility fractures in self-caring elderly patients aged 80 years and over

et al. 2021

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Background This study aimed to prospectively analyze the risk factors for new falls and fragility fractures in self-caring elderly patients and to find suitable evaluation tools for community screening and follow-up interventions. Methods: A total of 300 participants (187 male and 113 female), aged 80 or above and capable of caring for themselves, were enrolled in this study and observed for a period of 12 months. Their medical histories were collected, various indicators were measured, and the risk factors for new falls and fragility fractures were analyzed. Results A total of 290 participants were included in the statistical analysis. Eighty-seven participants (30%) had new falls. The incidence was negatively correlated with the activities of daily living (ADL, represented by the Barthel Index) score (P=0.008) but was positively correlated with the timed up-and-go (TUG) test score> 12 s (P=0.021). The results also revealed that 33 fragility fractures occurred in 29 patients (10.0%), which was positively correlated with new falls (P=0.000). New fragility fractures were negatively correlated with the bone mineral density (BMD) of the lumbar vertebrae (P=0.012) and walking speed (P=0.000). Conclusion TUG, walking speed, the ADL score, and the fall risk assessment scale can simply and effectively assess the risk of new falls and fragility fractures in the elderly population, and their use should be widely implemented in the community.

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Section: Discussionmentioning

confidence: 99%

A prospective cohort study of the risk factors for new falls and fragility fractures in self-caring elderly patients aged 80 years and over

et al. 2021

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“…Biochemical for intrinsic capacity and frailty are nucleic acid‐based, protein‐based, and metabolic‐based. Frailty is significantly associated with biomarkers (Morley, 2020 ). Patients with schizophrenia may have elevated level of certain adverse biochemical markers due to their long‐term use of antipsychotics (Kraguljac et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Prediction of physiological state, cognition, sensory function, and biomarkers for frailty in patients aged 55 years or more with schizophrenia

Tsai

Chang

2023

Nursing Open

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Aim We explored the performance of demographic characteristics, physiological state, cognitive function, sensory function, and biomarkers when used as predictors of frailty for patients with schizophrenia. Design A cross‐sectional study design was adopted. Methods Demographic data and data on physiological state, cognitive function, sensory function, biochemical indices, and frailty status of patients with schizophrenia were collected. The data were analysed using descriptive statistics, a chi‐square test, one‐factor analysis of variance, and logistic regression. Results The results revealed that frailty was prevalent among patients with lower educational attainment, longer hospital stay, higher skeletal muscle mass, higher basal metabolic rate, lower cognitive function, the use of tranquillisers and sleeping pills, and the use of assistive equipment as well as having fallen in the past year. In addition, cognitive function (p < 0.05), use of a wheelchair (p < 0.05), and use of an assistive walker (p < 0.001) were used as predictors of frailty condition of patients with schizophrenia. Patient Contribution Patients with schizophrenia have higher risk of having complications than patients with other chronic illnesses. Therefore, medical staff should regularly assess the levels of frailty risk to help patients with schizophrenia.

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Prediction of Physical Frailty at Hospital Discharge in Critically Ill Older Patients

Nonoyama,

Kubota,

Takayama

et al. 2024

Physical & Occupational Therapy In Geriatrics

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Physical Frailty: A Biological Marker of Aging?

Cited by 4 publications

References 49 publications

A prospective cohort study of the risk factors for new falls and fragility fractures in self-caring elderly patients aged 80 years and over

A prospective cohort study of the risk factors for new falls and fragility fractures in self-caring elderly patients aged 80 years and over

Prediction of physiological state, cognition, sensory function, and biomarkers for frailty in patients aged 55 years or more with schizophrenia

Prediction of Physical Frailty at Hospital Discharge in Critically Ill Older Patients

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