Prominent Decrease of Tear Meniscus Height With Contact Lens Wear and Efficacy of Eye Drop Instillation

Nagahara, Yukiko; Koh, Shizuka; Maeda, Naoyuki; Nishida, Kohji; Watanabe, Hitoshi

doi:10.1097/icl.0000000000000134

Cited by 27 publications

(27 citation statements)

References 37 publications

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“…41 A human study also showed the increased tear meniscus height after topical application of 3% diquafosol eye drops, proving its efficacy for contact lens wearers. 42 Diquafosol improves tear stability, vital staining score, and symptoms. 43 If diquafosol is not sufficient, a punctal plug could be an option.…”

Section: Treatment Targeting the Tear Filmmentioning

confidence: 96%

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Kojima

2018

Invest. Ophthalmol. Vis. Sci.

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Contact lens wearers complain of various types of contact lens discomfort (CLD), which may result in the discontinuation of contact lenses. CLD is often associated with dry eye disease. A contact lens divides the tear film into two layers: the pre-and post-lens tear film. This change leads to instability of the pre-lens tear film, thinning of pre-and post-lens tear film thickness, and increased friction between the contact lens and the ocular surface. The Japanese Dry Eye Society recommends the diagnosis of tear film abnormality first (tear film-oriented diagnosis [TFOD]) and the treatment of dry eye disease based on TFOD (tear film-oriented therapy [TFOT]). These concepts can be applied for contact lens-associated dry eye disease (CLADE). Noninvasive tear film breakup time, tear volume evaluation, vital staining, and assessment of Meibomian glands are performed to evaluate the tear film. On vital staining analysis of CLADE, lid wiper epitheliopathy and conjunctival edge staining are major findings. In TFOT of CLADE, secretagogues of water or mucins, such as diquafosol and rebamipide, have been first used in Japan. Material, design, wettability, and friction coefficient of the contact lens could affect CLADE. Changes of contact lens may be an option in TFOD. However, the effects of contact lens properties on the tear film and ocular surface are still unclear. Further controlled studies are needed in the future.

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Section: Treatment Targeting the Tear Filmmentioning

confidence: 96%

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Kojima

2018

Invest. Ophthalmol. Vis. Sci.

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“…70,71 Several biophysical changes in the tear film, such as increased evaporation, decreased stability, decreased prelens lipid layer thickness, decreased tear volume, and changes in the tear composition, have been associated with contact lens discomfort. 72,73 Blurry, fluctuating vision associated with contact lens discomfort has been a common problem for soft contact lens wearers. 74 A significant decrease in the retinal image quality associated with soft contact lens wear has been determined by measuring the point spread function of the eye, 75 visual acuity for low-contrast letters, 76 and corneal light scattering.…”

Section: Prelens Tear Filmmentioning

confidence: 99%

“…73,79 The biocompatibility of a lens material in tear fluid is largely dependent on the wetting nature of the material. 80 With new technologies entering the market, several options, such as lenses with internal wetting agents and silicone hydrogel lenses, have become available for patients seeking relief from contact lens-related dryness.…”

Section: Prelens Tear Filmmentioning

confidence: 99%

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

Koh

Higashiura

Maeda

2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Quality of vision has been emphasized in ophthalmologic clinical practice in recent years. The optical or visual performance of the human eye is not static and fluctuates over time. Considering the major origins of temporal fluctuations in optical or visual performance, quantitative assessment of the dynamic changes in the optical quality of the entire eye is important. This review provides an overview of the clinical application of the objective methods for assessing dynamic changes in optical quality, particularly those associated with accommodation, the precorneal tear film, the prelens tear film, and contact lens movement and fitting.

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“…Artificial tears and tear retention agents have been widely used as possible options for tear supplementation during CL wear. Our previous preliminary investigation in a limited number of subjects showed a significant increase in TMH at 5 minutes after instillation of 3% diquafosol ophthalmic solution (Diquas, ophthalmic solution 3%; Santen Pharmaceutical, Osaka, Japan) during high-water-content CL wear 2. Diquafosol ophthalmic solution stimulates secretion of tear fluid and mucin.…”

Section: Introductionmentioning

confidence: 99%

Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

Nagahara

Koh

Nishida

et al. 2015

OPTH

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PurposeThis study aimed to evaluate the increase in tear meniscus height (TMH) induced by 3% diquafosol ophthalmic solution in eyes with contact lens (CL).MethodsTen healthy subjects wearing high-water-content CLs received topical instillation of two ophthalmic solutions – 3% diquafosol ophthalmic solution in one eye and artificial tears in the other eye. Lower TMH was measured at 5 minutes, 10 minutes, 15 minutes, 30 minutes, and 60 minutes after instillation by anterior segment optical coherence tomography.ResultsTMH increased significantly (P<0.001) at 5 minutes and 15 minutes after instillation of saline compared with the baseline values. After instillation of 3% diquafosol ophthalmic solution, TMH significantly increased (P<0.05) at 5 minutes, 15 minutes, 30 minutes, and 60 minutes compared with the baseline values. Increases in TMH after diquafosol instillation were significantly greater (P<0.05) at 15 minutes, 30 minutes, and 60 minutes than increases in TMH after saline instillation.ConclusionTopical instillation of 3% diquafosol ophthalmic solution increases TMH for up to 60 minutes in eyes with high-water-content CLs.

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Prominent Decrease of Tear Meniscus Height With Contact Lens Wear and Efficacy of Eye Drop Instillation

Cited by 27 publications

References 37 publications

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

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Prominent Decrease of Tear Meniscus Height With Contact Lens Wear and Efficacy of Eye Drop Instillation

Cited by 27 publications

References 37 publications

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Overview of Objective Methods for Assessing Dynamic Changes in Optical Quality

Prolonged increase in tear meniscus height by&nbsp;3%&nbsp;diquafosol ophthalmic solution in eyes with&nbsp;contact lenses

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Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses