Prolonged increase in tear meniscus height by&amp;nbsp;3%&amp;nbsp;diquafosol ophthalmic solution in eyes with&amp;nbsp;contact lenses

Nagahara, Yukiko; Koh, Shizuka; Nishida, Kohji; Watanabe, Hitoshi

doi:10.2147/opth.s86173

Cited by 17 publications

(12 citation statements)

References 14 publications

(19 reference statements)

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“…41 They also conducted a clinical study and found that increased tear meniscus in contact lens wearers was maintained 60 minutes after topical application of 3% diquafosol eye drops. 57 Further studies are needed to evaluate the efficacy of topical 3% diquafosol eye drops to treat CLADE.…”

Section: Recent Advances In Japanmentioning

confidence: 99%

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Kojima

2018

Invest. Ophthalmol. Vis. Sci.

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Contact lens wearers complain of various types of contact lens discomfort (CLD), which may result in the discontinuation of contact lenses. CLD is often associated with dry eye disease. A contact lens divides the tear film into two layers: the pre-and post-lens tear film. This change leads to instability of the pre-lens tear film, thinning of pre-and post-lens tear film thickness, and increased friction between the contact lens and the ocular surface. The Japanese Dry Eye Society recommends the diagnosis of tear film abnormality first (tear film-oriented diagnosis [TFOD]) and the treatment of dry eye disease based on TFOD (tear film-oriented therapy [TFOT]). These concepts can be applied for contact lens-associated dry eye disease (CLADE). Noninvasive tear film breakup time, tear volume evaluation, vital staining, and assessment of Meibomian glands are performed to evaluate the tear film. On vital staining analysis of CLADE, lid wiper epitheliopathy and conjunctival edge staining are major findings. In TFOT of CLADE, secretagogues of water or mucins, such as diquafosol and rebamipide, have been first used in Japan. Material, design, wettability, and friction coefficient of the contact lens could affect CLADE. Changes of contact lens may be an option in TFOD. However, the effects of contact lens properties on the tear film and ocular surface are still unclear. Further controlled studies are needed in the future.

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Section: Recent Advances In Japanmentioning

confidence: 99%

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Kojima

2018

Invest. Ophthalmol. Vis. Sci.

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“…Topical administration of cyclosporine has been shown to increase tear fluid secretion, goblet cell density and decreases epithelial cell apoptosis and inflammatory cytokines in the conjunctiva and lacrimal glands, but it is clear that many patients with DED do not show a consistent therapeutic response to topical cyclosporine 11 – 13 . Diquafosol stimulates section of fluid and mucin from the conjunctiva directly on the ocular surface by interacting with the P2Y2 receptors to increase the tear film stability 14 . Fujihara T et al .…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of hydroxyproline-GQDGLAGPK in desiccation stress-induced experimental dry eye mouse

Lee

Kim

Ahn

et al. 2017

Sci Rep

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The purpose of this study has been the investigation of the effect of novel peptide hydroxyproline-GQDGLAGPK (Hyp-GQDGLAGPK) in desiccation stress-induced dry eye mouse model and compared medicines for dry eye disease including cyclosporine, diquafosol and sodium hyaluronate. Seventy eight NOD.B10.H2 b mice were injected with scopolamine and exposed to an air draft for 10 days, and then the mice were treated with normal saline (n = 13), 1% Hyp-GQDGLAGPK (n = 13), 0.05% cyclosporine (n = 13), 3% diquafosol (n = 13), and 0.1% hyaluronate (n = 13) for 10 days. Thirteen mice were used for histopathologic analysis at DS 10d. The desiccation stress significantly decreased tear production, but the topical treatment of Hyp-GQDGLAGPK recovered to the baseline levels, which was similar to cyclosporine and diquafosol. In addition, Hyp-GQDGLAGPK improved facilitating epithelium stabilization including the corneal irregularity score, fluorescein score and detachment of the corneal epithelium. These improvements in stabilization of the corneal epithelium was superior to that in the cyclosporine and sodium hyaluronate groups. Furthermore, desiccation stress markedly induced expression of autoimmune inflammation-related factors in the lacrimal glands, but it was significantly suppressed by Hyp-GQDGLAGPK treatment. Overall, we found that novel peptide Hyp-GQDGLAGPK has multi-functional effects such as stabilizing the tear film and inhibiting inflammation.

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“…10,11 Diquafosol stimulates the secretion of sialic acid, which is a mucin-like substance, as well as mucin from the conjunctiva, directly onto the ocular surface. 12,13 Several studies demonstrated that diquafosol promotes tear fluid and a good safety profile with clinical improvement of the ocular surface in patients with severe DE. [13][14][15] However, some studies have reported that diquafosol may not act on the lacrimal glands directly or not provide a major improvement in symptoms related to DE.…”

mentioning

confidence: 99%

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

Lee

Jeon

Kim

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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The aim of this study was the investigation of the effect of sulglycotide (SOS), a polysulfated glycopeptide derived from porcine duodenal mucin, for the treatment of dry eye disease. METHODS. NOD.B10.H2 b mice were exposed to an air draft for 10 days, and, simultaneously, scopolamine hydrobromide was injected subcutaneously. The mice were randomly divided into nine groups as follows: four kinds of SOS formulations and three kinds of commercial medicine. After 10 days of treatment, we estimated the effect of treatment on tear production, epithelium stabilization, mucin secretion, and inflammation. RESULTS. The desiccation stress significantly decreased tear production and corneal epithelium stabilization, as well as markedly decreased the numbers of goblet cells and mucin-stained cells in conjunctiva. However, the topical 4% SOS eye drops markedly increased tear production and corneal stabilization, which recovered to baseline levels. In addition, topical 4% SOS significantly induced an increase in the numbers of goblet cells and the expression of membrane-associated mucins including MUC1, MUC4, and MUC16, as well as the gel-forming mucin, MUC5AC. Furthermore, SOS formulations provided anti-inflammatory improvement in a dose-dependent manner. CONCLUSIONS. In summary, we suggest that a new ophthalmic pharmaceutical formulation, topical sulglycotide, enhances the ocular mucin secretion in dry eye disease and can be used as a new ophthalmic pharmaceutical material to treat dry eye disease.

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Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

Cited by 17 publications

References 14 publications

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Contact Lens-Associated Dry Eye Disease: Recent Advances Worldwide and in Japan

Anti-inflammatory effect of hydroxyproline-GQDGLAGPK in desiccation stress-induced experimental dry eye mouse

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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