Prolonged Apnœa Following Injection of Succinyldicholine

Forbat, Andrew F.; Lehmann, H.; Silk, E.

doi:10.1016/s0140-6736(53)90670-9

Cited by 37 publications

(19 citation statements)

References 12 publications

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“…It was only a year following the elucidation of the metabolic fate of suxamethonium that Forbat et al [88] reported two brothers both of whom had very low levels of plasma cholinesterase activity. They concluded 'further cases of sensitivity to succinyldicholine should be published and, if a low pseudocholinesterase level is found which cannot be explained by disease, malnutrition or poisoning, their families should be investigated for a hereditary or racial basis of abnormally low pseudocholinesterase level'.…”

Section: Inherited Variationsmentioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

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SummaryPlasma cholinesterase is an enzyme which has importance to the anaesthetist primarily for its rôle in the metabolism of suxamethonium, although other anaesthetic related drugs that this enzyme metabolises are also increasingly important. In this article we review current thoughts on the function, profile and chemistry of plasma cholinesterase. Causes of variations in the activity of the enzyme are described and the basis of genetic variations is explained.

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Section: Inherited Variationsmentioning

confidence: 99%

Cholinesterase Its significance in anaesthetic practice

1997

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“…It had already been suggested that there could be an hereditary basis for the low serum cholinesterase levels where hepatic function appeared normal (Forbat et al, 1953;Lehmann and Ryan, 1956;Lehmann et al, 1958). The use of dibucaine now became the means of confirming this hypothesis.…”

Section: Pharmacogenetics Ofsuxamethaniummentioning

confidence: 97%

Assay of Cholinesterase in Clinical Chemistry

1979

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“…3.1.1.8) and their enzymatic hydrolysis is responsible for the termination of their toxicity. 5,6 Drugs that inhibit PChE, therefore, may increase the toxicity of succinylcholine and local anaesthetics.7 '8 Esmolol and its metabolite may inhibit PChE, based on their chemical structure. Such an inhibition may prolong the duration of neuromuscular block of succinylcholine and increase the toxicity of ester-type local anaesthetics.…”

Section: -[4-(2-hydrory-3-(isopropylamino)propoxy)-phenyl]propionic mentioning

confidence: 99%