Prolonged activated partial thromboplastin time in thromboprophylaxis with unfractionated heparin in patients undergoing cesarean section

Matsubara, Shigeki; Usui, Rie; Ohkuchi, Akihide; Okuno, Satsuki; Izumi, Akio; Watanabe, Takashi; Seo, Norimasa; Suzuki, Michitaka

doi:10.1111/j.1447-0756.2009.01107.x

Cited by 13 publications

(9 citation statements)

References 9 publications

(19 reference statements)

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“…As described previously, 4 our institute employed ‘universal’ heparin thromboprophylaxis after CS. All patients received heparin irrespective of risk, excluding cases at risk of hemorrhagic complications by heparin administration.…”

Section: Methodsmentioning

confidence: 99%

“…Thromboprophylaxis and APTT were measured as described previously 4 . In short, APTT was measured before CS (from 28 days until just before CS) (preoperative APTT).…”

Section: Methodsmentioning

confidence: 99%

“…The activated partial thromboplastin time (APTT) reflects the clotting status, and thus the general hemorrhagic tendency. Previously, we showed how UH thromboprophylaxis increased APTT 4 . How does LMWH increase APTT if it is used soon after CS?…”

Section: Introductionmentioning

confidence: 95%

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No increase in hemorrhagic complications with thromboprophylaxis using low‐molecular‐weight heparin soon after cesarean section

Watanabe¹,

Matsubara²,

Usui³

et al. 2011

J of Obstet and Gynaecol

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Section: Methodsmentioning

confidence: 99%

“…Thromboprophylaxis and APTT were measured as described previously 4 . In short, APTT was measured before CS (from 28 days until just before CS) (preoperative APTT).…”

Section: Methodsmentioning

confidence: 99%

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No increase in hemorrhagic complications with thromboprophylaxis using low‐molecular‐weight heparin soon after cesarean section

Watanabe¹,

Matsubara²,

Usui³

et al. 2011

J of Obstet and Gynaecol

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“…Activated Partial Thromboplastin Time. To determine whether heparin retained its functional activity when conjugated onto the CNCs, an aPTT assay was used to determine the anticoagulant effect of the CNC-H. 54,55 In vitro aPTT tests revealed that the CNCs conjugated with heparin effectively prolonged the time until in vitro clot formation of blood (Figure 5A). The CNC-H successfully induced the return of aPTT to its normal value, whereas the CNC-only treatment reduced aPTT to less than half of the normal value.…”

Section: Preparation Of Heparin-conjugated Carbon Nanocapsulesmentioning

confidence: 99%

Treatment of Acute Thromboembolism in Mice Using Heparin-Conjugated Carbon Nanocapsules

Tang¹,

Chang²,

Tang³

et al. 2012

ACS Nano

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The unsurpassed properties in electrical conductivity, thermal conductivity, strength, and surface area-to-volume ratio allow for many potential applications of carbon nanomaterials in various fields. Recently, studies have characterized the potential of using carbon nanotubes (CNTs) as a biomaterial for biomedical applications and as a drug carrier via intravenous injection. However, most studies show that unmodified CNTs possess a high degree of toxicity and cause inflammation, mechanical obstruction from high organ retention, and other biocompatibility issues following in vivo delivery. In contrast, carbon nanocapsules (CNCs) have a lower aspect ratio compared with CNTs and have a higher dispersion rate. To investigate the possibility of using CNCs as an alternative to CNTs for drug delivery, heparin-conjugated CNCs (CNC-H) were studied in a mouse model of acute hindlimb thromboembolism. Our results showed that CNC-H not only displayed superior antithrombotic activity in vitro and in vivo but they also had the ability to extend the thrombus formation time far longer than an injection of heparin or CNCs alone. Therefore, the present study showed for the first time that functionalized CNCs can act as nanocarriers to deliver thrombolytic therapeutics.

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“…Pulmonary embolism (PE) develops mainly from deep vein thrombosis (DVT) in pregnant women, especially during labor and immediately after delivery . A transient inferior vena cava filter (IVC filter) has been employed for PE prophylaxis during these periods .…”

Section: Introductionmentioning

confidence: 99%

Thrombus just beneath a retrievable inferior vena cava filter in a pregnant woman with deep vein thrombosis: Its removal requiring catheter thrombus fragmentation with fibrinolysis

Horie

Suzuki

Ohkuchi

et al. 2013

J of Obstet and Gynaecol

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Recently, transient inferior vena cava (IVC) filters have been employed to protect against pulmonary embolism (PE) in pregnant women with deep vein thrombosis. A 34-year-old primiparous Japanese woman with a history of myomectomy was diagnosed with deep vein thrombosis by ultrasound at 27 weeks of gestation. Unfractionated heparin was administered, which soon ameliorated swelling in the right thigh. A transient IVC filter was implanted just before cesarean section. An enhanced computed tomography scan 2 days after cesarean section revealed a wide thrombus just distal to the filter. We performed catheter thrombus fragmentation with fibrinolysis just before the removal of the IVC filter, resulting in re-canalization of blood flow. No significant PE occurred. Although a transient IVC filter may work well for the prophylaxis of PE during labor and delivery, catheter fragmentation with fibrinolysis may become necessary at removal of the filter.

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Prolonged activated partial thromboplastin time in thromboprophylaxis with unfractionated heparin in patients undergoing cesarean section

Cited by 13 publications

References 9 publications

No increase in hemorrhagic complications with thromboprophylaxis using low‐molecular‐weight heparin soon after cesarean section

No increase in hemorrhagic complications with thromboprophylaxis using low‐molecular‐weight heparin soon after cesarean section

Treatment of Acute Thromboembolism in Mice Using Heparin-Conjugated Carbon Nanocapsules

Thrombus just beneath a retrievable inferior vena cava filter in a pregnant woman with deep vein thrombosis: Its removal requiring catheter thrombus fragmentation with fibrinolysis

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