No increase in hemorrhagic complications with thromboprophylaxis using low‐molecular‐weight heparin soon after cesarean section

Abstract

Compared with thromboprophylaxis with unfractionated heparin, thromboprophylaxis with early administration of LMWH after cesarean section did not increase the incidence of hemorrhagic complications and caused less prolongation of the activated partial thromboplastin time in Japanese women.

Safety and efficacy of thromboprophylaxis using enoxaparin sodium after cesarean section: A multi-center study in Japan

“…Whether the hematoma was related to administration of enoxaparin sodium, or placement or removal of the subcutaneous drain is unknown. The study findings are broadly comparable with other reports in which Japanese women received enoxaparin sodium after C/S according to a similar protocol [11]. Currently there are no reported incidences of DVT in women receiving thromboprophylaxis using unfractionated heparin or LMWH after C/S.…”

“…Many investigators have reported that LMWH is a safe means of providing thromboprophylaxis after C/S [8e12]. Enoxaparin sodium was only recently granted a license in Japan for thromboprophylaxis and there have been few evaluations of its safety in pregnant Japanese women [11]. The efficacy of enoxaparin sodium has been established in a series of studies that used the clinical signs of VTE after major surgery [10,13,14].…”

A comparison of the safety of two different enoxaparin doses for thromboprophylaxis following cesarean section

“…In another study, it was calculated that to prevent each DVT, treatment with LMWH would cause two major hemorrhages, seven wound hematoma, and si transfusion cases (3,21). In contrast, Watanabe et al reported that enoxaparin started immediately after caesarean did not increase the incidence of hemorrhagic complications and showed that of 131 cases, there was only one case of potential incision hematoma, and no change was recorded in hemoglobin (22). In the current study, of the 25 patients who received 40mg/day enoxaparin, WSI developed in two patients and no cases of WSH or DVT were observed.…”

Low molecular weight heparin: a promising anticoagulant in pregnancy

“…19 In a study in Japanese women, there was no increase in hemorrhagic complications and less prolongation of activated partial thromboplastin time with thromboprophylaxis using LMWH compared to UFH soon after cesarean section. 20 Enoxaparin versus fractionated heparin in recurrent abortion secondary to antiphospholipid syndrome. Conclusion: LMWH plus low dose aspirin (LDA) was successfully used as an alternative to UFH plus LDA in the management of recurrent abortion secondary to AntiPhospholipid Syndrome (APS).…”