Prolactin gene polymorphism in Nili‐Ravi buffaloes in relation to Sahiwal and Achai Cattle

Ishaq, Rafaqat; Suleman, Muhammad; Riaz, Muhammad Naeem; Yousaf, Muhammad; Shah, Abdullah; Ghafoor, Abdul

doi:10.1111/j.1471-0307.2012.00875.x

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…(-) ) frequency was 0.76, and was found to be more prominent than the A allele. This result is similar to the findings of earlier researchers, who reported genotype frequencies in various regions of the world with different breeds and sample sizes (Dybus et al, 2002;Miceikienė et al, 2006;Alipanah et al, 2008;Mehmannavaz et al, 2009;Rorie et al, 2009;Kaplan & Boztepe 2010;Sodhi et al, 2011;Alfonso et al, 2012;Boleckova et al, 2012;Das et al, 2012;Ishaq et al, 2012). However, Dybus et al (2005) found a lower G allele frequency in Jerseys.…”

Section: Methodssupporting

confidence: 80%

“…The most important polymorphism was located and identified by RsaI endonuclease using PCR-RFLP (Mitra et al, 1995;Brym et al, 2005). These polymorphic structures have been studied by many researchers, who confirmed statistically significant associations between these polymorphic variants and milk production traits in cattle (Dybus et al, 2005;Brym et al, 2005;He et al, 2006;Alipanah et al, 2008;Mehmannavaz et al, 2009;Rorie et al, 2009;Alfonso et al, 2012;Boleckova et al, 2012;Ishaq et al, 2012;Akyuz et al, 2012;Akyuz & Cınar, 2014;Ozkan Unal et al, 2015). It was suggested that PRL variants could be useful in direct selection programmes for improving milk traits in livestock (He et al, 2006;Alipanah et al, 2008;Rorie et al, 2009;Alfonso et al, 2012;Boleckova et al, 2012;Akyuz et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Prolactin-RsaI gene polymorphism in East Anatolian Red cattle in Turkey

Sönmez¹,

Özdemir²

2017

SA J. An. Sci.

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Prolactin (PRL) plays an important role in regulating mammary gland development, secreting milk, and expressing milk protein genes; making it a potential genetic marker and a candidate gene for production traits in dairy animals. The aim of the study was to determine by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method the gene and genotype frequencies of PRL gene in native East Anatolian Red (EAR) cattle, which are raised as a genetic resource in Turkey. PCR-RFLP analysis involved the use of the RsaI restriction enzyme. Three patterns of fragments were obtained. The AA, AG, and GG genotype frequencies were 0.07, 0.34, and 0.59 in the cattle population, respectively. For Prolactin-RsaI (PRL-RsaI) polymorphism, the population was in Hardy-Weinberg equilibrium. Heterozygosity was found at a medium rate as 0.338 and the calculated F IS value was 0.072.

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Section: Methodssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Prolactin-RsaI gene polymorphism in East Anatolian Red cattle in Turkey

Sönmez¹,

Özdemir²

2017

SA J. An. Sci.

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“…The low G allele (0.8750) at NTB might be due to limited number of the heterozygous AG genotype in this population. The G allele frequency of the PRL gene at exon 4 of bali cattle identified in this study was higher than those in some cattle breeds such as Chinese Holstein (0.8754, Dong et al, 2013;0.893, Lü et al, 200), Iranian Holstein (0.931, Mehmannavaz et al, 2009), Colombia Holstein (0.833, Rincon et al,20), Sahiwal (0.810, Ishaq et al, 2013), Achai (0.560, Ishaq et al,203), and Black-and-White, (0.887, Brym et al, 2005). Brym et al (2005) in their study about association of bovine prolactin gene exon 4 polymorphism with milk performance traits in Black-and-White cattle revealed that cows with AG genotype showed the highest milk yield, while cows with GG genotype showed the highest fat content.…”

Section: Genetic Polymorphism Of the Prl Genecontrasting

confidence: 46%

The Genetic Variability of Prolactin and Signal Transducers and Activators of Transcription 5A (STAT5A) Genes in Bali Cattle

Paramitasari

Sumantri

Jakaria

2015

Med Pet

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The aim of this study was to identify the genetic variability of PRL and STAT5A genes in Bali cattle from Bali, West Nusa Tenggara (NTB), and South Sulawesi (SS) using PCR-RFLP method. A total of 262 Bali cattle were identified using RsaI (PRL) and AvaI (STAT5A) restriction enzymes. PRL gene exon 3, PRL gene exon 4, and STAT5A gene exon 7 amplifications resulted fragments with the lengths of 156 bp, 294 bp, 215 bp, respectively. Genotyping of PRL gene both at exon 3 and 4 produced three genotypes in Bali population and two genotypes in NTB and SS population. For the PRL gene, frequencies of A allele (exon 3) and G allele (exon 4) were dominant to the B allele (exon 3) and A allele (exon 4) across all populations. The results showed that STAT5A|AvaI loci had monomorphic C allele. Heterozygosity values were found low at both exons 3 and 4 of PRL gene in all population. Sequence analysis results of PRL gene both for exons 3 and 4 showed that there was a mutation between adenine (A) and guanine (G) bases in the RsaI recognized site, whereas in STAT5A gene we can confirm the existence of AvaI restriction site (C|CCGAG).

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“…The frequencies of PRL alleles obtained in this study are similar to those reported in some earlier studies (e.g., Mitra et al, 1995;Chung et al, 1996;Chrenek et al, 1998bChrenek et al, , 1999Dybus, 2002a;Alipanah et al, 2007Alipanah et al, , 2008Kumari et al, 2008) for the different taurine cattle breeds as indicated in Table 6 (Swiss Brown, Slovak Pinzgauer, Korean cattle breeds, Red Angus, Russian Red Pied, Jersey, Russian Black Pied, Red Pied, etc.). Studies of the PRL gene of cattle from different countries reported that the frequency of the A allele was higher in some European Bos taurus cattle breeds (Mitra et al, 1995;Chung et al, 1996;Chrenek et al, 1998aChrenek et al, , 1998b and lower in the Bos indicus cattle breeds (Mitra et al, 1995;Kumari et al, 2008;Sodhi et al, 2011;Dayal Das et al, 2012;Mahajan et al, 2012;Ishaq et al, 2013), as shown in Table 6.…”

Section: Prl Polymorphismmentioning

confidence: 99%

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

Ünal¹,

Kepenek²,

Dinç³

et al. 2015

Turk J Zool

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IntroductionGenetic research in farm animals focuses mainly on the identification of genes influencing economically important traits that could be useful in breeding programs. In dairy cattle, most studies have researched the genes that may determine variations in milk yield and milk composition (Komisarek and Dorynek, 2009). The polymorphisms of several genes including growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) have been shown to affect milk yield and milk composition traits in dairy cattle.GH belongs to a family of somatolactogenic hormones including prolactin, placental lactogen, and a number of hematopoietic growth factors (Cosman et al., 1990). GH is located on the 19th chromosome in the q26-qter band region (Hediger et al., 1990). The GH gene of cattle is approximately 1800 bp in size and contains 5 exons and 4 introns. This gene encodes an mRNA with a size of 786 bp (Woychik et al., 1982). Although a number of polymorphisms have been observed in the GH gene of cattle, the 2 polymorphisms that are located in intron 3 and exon 5 have been found to be significant in their effects on milk and meat yield parameters (Lucy et al., 1991(Lucy et al., , 1993Høj et al., 1993). The polymorphism in intron 3 of GH is observed when GH is digested by the restriction enzyme MspI (GH-MspI) (Zhang et al., 1993). Two alleles are observed as a result of digestion with this enzyme. The first allele, GH-MspI ( -) contains a T insertion at the +837 position, and the second allele has a C-G transition at the +837 position (Lee et al., 1994). Zhang et al. (1993b) reported that the polymorphism in exon 5 could be observed when digested by the AluI enzyme (GH-AluI) and the 2 alleles called L (leucine in the 127th codon) and V (valine in the 127th codon) occur.The PRL gene is located on chromosome 23 and is composed of 5 exons and 4 introns (Camper et al., 1984, as cited by Skinkyte et al., 2005. A silent A-G mutation of the 103rd codon in exon 3 of the bovine PRL gene led to a polymorphic RsaI site (Lewin, 1992, as cited by Skinkyte et al., 2005). The polymorphism leading to the RsaI enzyme restriction site of the bovine PRL gene determines milk production traits including milk yield, milk fat, and milk protein contents (Lewin et al., 1992). The significant effect of the PRL locus on milk production traits was later shown by Chung et al. (1996, as cited by Dybus, 2002a as well.

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Prolactin gene polymorphism in Nili‐Ravi buffaloes in relation to Sahiwal and Achai Cattle

Cited by 9 publications

References 16 publications

Prolactin-RsaI gene polymorphism in East Anatolian Red cattle in Turkey

Prolactin-RsaI gene polymorphism in East Anatolian Red cattle in Turkey

The Genetic Variability of Prolactin and Signal Transducers and Activators of Transcription 5A (STAT5A) Genes in Bali Cattle

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

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