Projeto, fabricação e avaliação de implantes craniofaciais personalizados: proposta de utilização de materiais combinados

Bertol, Liciane Sabadin; Escobar, Camila Ferreira; Kindlein, Wilson; Santos, Luís Alberto dos; Medeiros, Eubirajara Bezerra; Torriani, Marcos Antônio; Bergmann, Carlos Pérez

doi:10.4322/rbeb.2012.081

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…It is notable that the calcium phosphate compounds induce a minimal inflammatory reaction and are well tolerated, inert and bioactive (Bertol et al, 2010), having been used in various clinical specialties such as orthopedics, orthodontics and plastic surgery in general (Nakadate et al, 2008;Marukawa et al, 2010). However, its use in ophthalmic plastic surgery is still fairly rare (Oriá et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Gomes

Oriá

Neto

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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The purpose of this study was to evaluate the macroscopy and microstructure of a double setting alphatricalcium phosphate bone cement sphere provided with interconnection channels (alpha-TCP-i), as well as the integration of the implant with the rabbits' orbital tissue, through macroscopic analysis and histopathology. The external and internal surfaces of the alpha-TCP-i were evaluated macroscopically and by electron microscopy. Twelve New Zealand rabbits received 12mm implants of alpha-TCP-i following enucleation of the left eye. The clinical assessment was undertaken daily during the first 15 days, followed by fortnightly assessment until the end of the study period. For the morphological analysis, exenteration was performed in 3 animals per experimental period (15, 45, 90 and 180 days). The external and internal surfaces of the implant appeared solid, smooth and compact, with six channels which interconnected centrally. The micro-architecture was characterized by the formation of columns of hexagonal crystals. No signs of infection, exposure, dehiscence of sutures or extrusion of the implant were noted in any of the animals during the entire period of the study. The morphological evaluation demonstrated the presence of a thin capsule around the implant, from whence appeared fibro-vascular projections, which penetrated it through the interconnecting channels. In the first days after the insertion of the implant, an intense inflammatory reaction was noted. At 180 days, however, there were no signs of inflammation. The alpha-tricalcium phosphate cement implant was well tolerated in this rabbit model and appeared to be relatively inert with some fibrovascular ingrowth through the large channels.Keywords: implant, eye, prosthesis RESUMO Avaliaram-se a macroscopia e a microestrutura de esferas compostas por cimento ósseo de alfa-fosfato tricálcico de dupla pega munido de canais de interconexão (alfa-TCP-i) e a integração do implante ao tecido orbital de coelhos através de análise macroscópica e histopatológica. A superfície interna e externa do alfa-TCP-i foi avaliada macroscopicamente e por microscopia eletrônica. Após enucleação do bulbo ocular esquerdo, 12 coelhos da raça Nova Zelândia receberam implantes do alfa-TCP-i com 12mm de diâmetro. A avaliação clínica foi realizada diariamente nos primeiros 15 dias e depois a cada quinze dias até o fim do período de estudo. Para análise morfológica, seguiu-se a exenteração de três animais por período experimental (15, 45, 90 e 180 dias). As superfícies externa e interna do implante mostraram-se compactas

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Section: Introductionmentioning

confidence: 99%

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Gomes

Oriá

Neto

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…Bertol et al (2010) conducted a study regarding the fabrication of custom implants, focusing on different alloplastic biomaterials (polymethylmethacrylate, titanium and calcium phosphate cements) and presented results similar to this study, although in that study, the implants were manufactured manually. In that case, the implant quality is dependent on the manual skill of the biomodeler.…”

Section: Discussionmentioning

confidence: 99%

Manufacture of custom-made cranial implants from DICOM® images using 3D printing, CAD/CAM technology and incremental sheet forming

Castelan¹,

Schaeffer

Daleffe

et al. 2014

Rev. Bras. Eng. Bioméd.

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Introduction: This work aims to pre-operatively manufacture custom-made low-cost implants and physical models ('biomodels') of fractured skulls. The pre-operative manufacturing of biomodels and implants allows physicians to study and plan surgery with a greater possibility of achieving the expected result. Customization contributes to both the esthetic and functional outcome of the implant because it considers the anatomy of each patient, while the low cost allows a greater number of people to potentially benefi t. Methods: From CT images of a fractured skull, a CAD model of the skull (biomodel) and a restorative implant were constructed digitally. The biomodel was then physically constructed with 3D Printing, and Incremental Sheet Forming (ISF) was used to manufacture the implant from a sheet of pure grade 2 titanium. Before cutting the implant's fi nal shape from a pre-formed sheet, heat treatment was performed to avoid deformations caused by residual stresses generated during the ISF process. Results: A comparison of the dimensions of the implant and its respective CAD biomodel revealed geometric discrepancies that can affect both functional and aesthetic effi ciency. Nevertheless, the fi nal shape preserved symmetry between the right and left sides of the skull. Electron microscopy analysis did not indicate the presence of elements other than pure titanium. Conclusions: Dimensional variability can be decreased with changes in the manufacturing process (i.e., forming and cutting) and the heating ramp. Despite biomedical characteristics, there was no contamination of the implant by harmful chemical elements. 3D Printing was effective in making the biomodel, enabling pre-operative planning and improving physicianpatient communication. Current results indicate that ISF is a process that can be used to obtain custom-made implants.

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“…A norma ASTM C1161 -18 [17], bem como os trabalhos de BERTOL et. al [18] e de BOEHM et. al [19] foram usados como referência na condução do ensaio.…”

Section: Ensaios De Flexão a Três Pontosunclassified

Análise das propriedades mecânicas e biológicas do cimento ósseo de fosfato de cálcio bifásico nanoestruturado de cura rápida

et al. 2020

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RESUMO Nas últimas duas décadas intensificaram-se os estudos para desenvolvimento de novas terapêuticas para aplicações em doenças degenerativas do tecido ósseo, bem como formas menos invasivas de tratamentos de traumas de acidentes viários. Neste cenário, biocimentos de fosfato de cálcio (CFCs) de cura rápida para aplicações injetáveis e/ou moldáveis, permitem o uso através de técnicas cirúrgicas minimamente invasivas. Matrizes de CFCs têm atraído grande interesse para uso em ortopedia e odontologia como substitutos para partes danificadas do sistema osteocondral, permitindo sua utilização na reparação ou preenchimento ósseo. Neste trabalho foram processados CFCs constituídos por dois diferentes fosfatos de cálcio bifásicos (BCP), um com distribuição micrométrica e outro com distribuição nanométrica, fosfato de sódio e carboximetilcelulose, visando a utilização deste material em procedimentos cirúrgicos. As matérias primas foram caracterizadas físico-quimicamente por difração de raio X, microscopia eletrônica de varredura acoplada com espectroscopia de energia dispersiva de raios X. O tempo de pega do material foi avaliado pelo ensaio de Vicat e a resistência mecânica do CFC foi avaliada através dos ensaios de Flexão (resistência mecânica a tração) e Ultramicrodureza (módulo de elasticidade). As propriedades biológicas foram avaliadas através dos ensaios in vitro de degradação em solução Tris-HCL e citotoxicidade em cultura de bactérias e ensaio in vivo pelo método de HET-CAM. Os resultados mostraram um melhor desempenho do BCP nanométrico, tendo tempo de pega final baixo, 22 minutos, e resistência mecânica da ordem de 4 MPa, compatível com a expectativa esperada para osso esponjoso. Os ensaios biológicos confirmaram a resposta biológica satisfatória destes nanocompósitos. Isso demonstra que o material tem potencial para aplicação clínica em substituição ao cimento acrílico hoje largamente utilizado.

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Projeto, fabricação e avaliação de implantes craniofaciais personalizados: proposta de utilização de materiais combinados

Cited by 4 publications

References 2 publications

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: A potential implant for the anophthalmic socket

Manufacture of custom-made cranial implants from DICOM® images using 3D printing, CAD/CAM technology and incremental sheet forming

Análise das propriedades mecânicas e biológicas do cimento ósseo de fosfato de cálcio bifásico nanoestruturado de cura rápida

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