Progressive Lateral Ventricular Enlargement in Schizophrenia: A Meta-Analysis of Longitudinal Mri Studies

A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

“…Interestingly, these regions appear to be among the hippocampal-cortical memory system, which are overlapped with default mode network [33]. The results indicate a progressive disconnection of hippocampal connectivity with default mode network in chronic phases of schizophrenia [47]. This increase is related to more severe positive symptoms at follow-up, supporting that progressive disconnection is predominantly associated with poor outcome among patients.…”

A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

“…Some longitudinal MRI studies have shown progressive brain tissue changes during the early years of first-episode SCZ (Cahn et al, 2002;Ho et al, 2003;Olabi et al, 2011;Andreasen et al, 2011), whereas other studies have failed to reveal such progressive loss in brain volume during the early phases of the illness (Dickey et al, 2004;Zipursky et al, 2004;DeLisi and Hoff, 2005;Schaufelberger et al, 2011;Roiz-Santianez et al, 2012; for a review, see Kempton et al, 2010;Olabi et al, 2011).…”

The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies

“…Moreover, in the case of studies that reported separately brain volumes for subgroups of patients treated with different pharmacologic treatments, we entered the results as if they were from separate studies. This technique was adopted by previous meta-analyses (8,32).…”

“…These abnormalities are largely evident from the first episode of schizophrenia (6) and are detectable before illness onset in prodromal/highrisk individuals (7). Longitudinal magnetic resonance imaging (MRI) studies have shown that these brain volume abnormalities in schizophrenia are progressive, with evidence that whole-brain and cortical GM volumes decrease and lateral ventricle volumes increase over time both in first-episode and chronic schizophrenia (8)(9)(10)(11). The nature of the pathophysiologic process underlying such progressive brain changes is still largely a matter of speculation.…”