A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Duan, Hongbo; Gan, Jing; Yang, Jia-ming; Cheng, Zhengxiang; Cun-you, Gao; Shi, Zhen-Juan; Zhu, Xiquan; Liang, Xuejun; Zhao, Long

doi:10.1016/j.bbr.2015.01.022

Cited by 33 publications

(26 citation statements)

References 52 publications

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“…In addition to previous research (e.g. Duan et al, 2015;Garrity et al, 2007) which found exclusively predictive relationship between connectivity strengths and positive symptom severity, we found that negative symptom severity was also a significant predictor. A potential explanation for this may reside in our choice of a DCM based directed connectivity assessment, i.e.…”

Section: Discussionsupporting

confidence: 71%

Effective connectivity of the hippocampus can differentiate patients with schizophrenia from healthy controls: a spectral DCM approach

Uscătescu

Kronbichler

Stelzig-Schöler

et al. 2020

Preprint

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We applied spectral dynamic causal modelling (spDCM; Friston et al., 2014) to analyze the effective connectivity differences between the nodes of three resting state networks (i.e. Default mode network/DMN, Salience network/SAN and Dorsal attention network/DAN) in a dataset of 31 healthy controls (HC) and 25 patients with schizophrenia (SZ), all male. Patients showed increased connectivity from the left hippocampus (LHC) to the dorsal anterior cingulate cortex (DACC), right anterior insula (RAI), left frontal eye fields (LFEF) and the bilateral inferior parietal sulcus (LIPS & RIPS), as well as increased connectivity from the right hippocampus (RHC) to the bilateral anterior insula (LAI & RAI), right frontal eye fields (RFEF) and RIPS. Moreover, negative symptoms predicted the connectivity strengths from the LHC to the DACC, the left inferior parietal sulcus (LIPAR) and the RHC, while positive symptoms predicted the connectivity strengths from the LHC to the LIPAR and from the RHC to the LHC. These results reinforce the crucial role of hippocampus dysconnectivity in SZ pathology and its potential as a biomarker of disease severity.

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Section: Discussionsupporting

confidence: 71%

Effective connectivity of the hippocampus can differentiate patients with schizophrenia from healthy controls: a spectral DCM approach

Uscătescu

Kronbichler

Stelzig-Schöler

et al. 2020

Preprint

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“…Functional imaging studies in patients with and at risk for schizophrenia consistently report changes in activation during verbal encoding and retrieval in the hippocampus and regions of the prefrontal cortex (Allen et al, 2011;Hofer et al, 2003;Kubicki et al, 2003;Ragland et al, 2001;Zierhut et al, 2010). Further studies also suggest abnormal resting state connectivity between the hippocampus and regions of the prefrontal cortex (Knochel et al, 2014;Kuhn et al, 2013;Cui et al, 2015;Zhou et al, 2008;Kraguljac et al, 2014;Duan et al, 2015;Tang et al, 2016). The same patients who had abnormal connectivity between the hippocampus and prefrontal cortex also had reduced hippocampal volume and abnormal white matter fibre integrity in the tracts connecting the hippocampus to regions of the frontal lobe (Knochel et al, 2014).…”

Section: Discussionmentioning

confidence: 98%

Reduction in human Lyme neuroborreliosis associated with a major epidemic among roe deer

Andersen

Skarphéðinsson

Knudtzen

et al. 2018

Ticks and Tick-borne Diseases

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Lyme neuroborreliosis is the most severe clinical manifestation of Lyme borreliosis. In most of Denmark, and also Europe, the overall prevalence of Lyme borreliosis seems to be stabilising. This is not the case on the island of Funen, Denmark, where the number of human Lyme neuroborreliosis cases has markedly declined throughout the last decade. We propose the reason for the decline is a major epidemic among roe deer, killing almost half of their population, resulting in a reduction in the tick population which make it less likely to get a tick bite and therefore to contract Lyme neuroborreliosis. This is the first time such a relationship is described as a naturally occurring phenomenon in Europe.

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“…It is intriguing that ketamine induces cortico-hippocampal circuitry alterations that are similar to those seen in schizophrenia 15 - 18 but does not replicate hippocampal connectivity abnormalities to the thalamus and to the striatum 13 - 15 , 61 , an area rich in dopaminergic innervation. This possibly reflects a dissociation of glutamate and dopamine system abnormalities, which is in agreement with prior studies failing to reverse ketamine induced psychosis with haloperidol, a dopamine D 2 receptor antagonist, in healthy subjects and volunteers with schizophrenia 22 , 62 .…”

Section: Discussionmentioning

confidence: 99%

“…Resting state functional Magnetic Resonance Imaging (fMRI) allows approximation of neuronal activity by measuring the temporal covariation of low frequency fluctuations of the blood oxygen level dependent (BOLD) signal 12 . In schizophrenia, aberrant hippocampal resting state connectivity to frontal areas including the anterior cingulate cortex (ACC), medial prefrontal cortex (MPFC), parietal areas including the posterior cingulate cortex (PCC) and precuneus, as well as the thalamus 13 , 14 and striatum 15 - 18 suggests disorganized neuronal activity, possibly related to NMDAR hypofunction 15 . Unfortunately, even contemporary imaging techniques cannot readily quantify NMDAR function in vivo .…”

Section: Introductionmentioning

confidence: 99%

Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers

et al. 2016

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A growing body of evidence suggests glutamate excess in schizophrenia and that N-methyl-d-aspartate receptor (NMDAR) hypofunction on γ-aminobutyric acid (GABA) interneurons disinhibiting pyramidal cells may be relevant to this hyperglutamatergic state. To better understand how NMDAR hypofunction affects the brain, we used Magnetic Resonance Spectroscopy and resting state functional MRI to study the effects of ketamine on hippocampal neurometabolite levels and functional connectivity in 15 healthy human subjects. We observed a ketamine induced increase of hippocampal Glx (glutamate+glutamine; F= 3.76; p= 0.04), a decrease in fronto-temporal (t=4.92, pFDR< .05, kE= 2198, x= -30, y= 52, z= 14) and temporo-parietal functional connectivity (t=5.07, pFDR< .05, kE= 6094, x= -28, y= -36, z= -2), and a possible link between connectivity changes and elevated Glx. Our data empirically support that hippocampal glutamatergic elevation and resting state network alterations may arise from NMDAR hypofunction and establish a proof of principle whereby experimental modelling of a disorder can help mechanistically integrate distinct neuroimaging abnormalities in schizophrenia.

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A longitudinal study on intrinsic connectivity of hippocampus associated with positive symptom in first-episode schizophrenia

Cited by 33 publications

References 52 publications

Effective connectivity of the hippocampus can differentiate patients with schizophrenia from healthy controls: a spectral DCM approach

Effective connectivity of the hippocampus can differentiate patients with schizophrenia from healthy controls: a spectral DCM approach

Reduction in human Lyme neuroborreliosis associated with a major epidemic among roe deer

Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers

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