A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Ferro, Adele; Roiz-Santiáñez, Roberto; Foz, Víctor Ortiz‐García de la; Tordesillas‐Gutiérrez, Diana; Ayesa-Arriola, Rosa; Fuente-González, Noemi de La; Fañanás, Lourdes; Brambilla, Paolo; Crespo‐Facorro, Benedicto

doi:10.1016/j.pscychresns.2014.10.023

Cited by 20 publications

(13 citation statements)

References 49 publications

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“…between gender and ICV and therefore brain size ( Table 8 ). Figures of regional volumes and coefficients of variation (CV) are also in line with the literature [ 18 , 40 , 71 – 73 ].…”

Section: Discussionsupporting

confidence: 86%

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Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases

et al. 2017

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Accurately describing the anatomy of individual brains enables interlaboratory communication of functional and developmental studies and is crucial for possible surgical interventions. The human parietal lobe participates in multimodal sensory integration including language processing and also contains the primary somatosensory area. We describe detailed protocols to subdivide the parietal lobe, analyze morphological and volumetric characteristics, and create probabilistic atlases in MNI152 stereotaxic space. The parietal lobe was manually delineated on 3D T1 MR images of 30 healthy subjects and divided into four regions: supramarginal gyrus (SMG), angular gyrus (AG), superior parietal lobe (supPL) and postcentral gyrus (postCG). There was the expected correlation of male gender with larger brain and intracranial volume. We examined a wide range of anatomical features of the gyri and the sulci separating them. At least a rudimentary primary intermediate sulcus of Jensen (PISJ) separating SMG and AG was identified in nearly all (59/60) hemispheres. Presence of additional gyri in SMG and AG was related to sulcal features and volumetric characteristics. The parietal lobe was slightly (2%) larger on the left, driven by leftward asymmetries of the postCG and SMG. Intersubject variability was highest for SMG and AG, and lowest for postCG. Overall the morphological characteristics tended to be symmetrical, and volumes also tended to covary between hemispheres. This may reflect developmental as well as maturation factors. To assess the accuracy with which the labels can be used to segment newly acquired (unlabelled) T1-weighted brain images, we applied multi-atlas label propagation software (MAPER) in a leave-one-out experiment and compared the resulting automatic labels with the manually prepared ones. The results showed strong agreement (mean Jaccard index 0.69, corresponding to a mean Dice index of 0.82, average mean volume error of 0.6%). Stereotaxic probabilistic atlases of each subregion were obtained. They illustrate the physiological brain torque, with structures in the right hemisphere positioned more anteriorly than in the left, and right/left positional differences of up to 10 mm. They also allow an assessment of sulcal variability, e.g. low variability for parietooccipital fissure and cingulate sulcus. Illustrated protocols, individual label sets, probabilistic atlases, and a maximum-probability atlas which takes into account surrounding structures are available for free download under academic licences.

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“…between gender and ICV and therefore brain size ( Table 8 ). Figures of regional volumes and coefficients of variation (CV) are also in line with the literature [ 18 , 40 , 71 – 73 ].…”

Section: Discussionsupporting

confidence: 86%

“…We consider this to be driven by leftward asymmetries of the postCG and SMG, and it may well be related to the majority of subjects being right handed (left-hemisphere dominant). Previously, this slight leftward asymmetry has been reported by some authors [ 18 , 73 ], but no asymmetry has been found by others [ 71 ].…”

Section: Discussionmentioning

confidence: 53%

Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases

et al. 2017

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“…The postcentral gyrus is known as the primary somatosensory cortex and plays a role in the representation of somatotopic information and the sensory reception of touch and kinesthesia. 52 Previous studies have found that schizophre nia patients have reduced white matter integrity of 2 major ascending tracts to the primary somatosensory cortex, 53 and reduced grey matter volume of the postcentral gyrus. 54 These findings are supported by decreased functional activation of the postcentral gyrus in schizophrenia.…”

Section: Discussionmentioning

confidence: 97%

Neurobiological commonalities and distinctions among 3 major psychiatric disorders: a graph theoretical analysis of the structural connectome

Wang

Gong

Zhong

et al. 2020

jpn

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Background: White matter network alterations have increasingly been implicated in major depressive disorder, bipolar disorder and schizophrenia. The aim of this study was to identify shared and distinct white matter network alterations among the 3 disorders. Methods: We used analysis of covariance, with age and gender as covariates, to investigate white matter network alterations in 123 patients with schizophrenia, 123 with bipolar disorder, 124 with major depressive disorder and 209 healthy controls. Results: We found significant group differences in global network efficiency (F = 3.386, p = 0.018), nodal efficiency (F = 8.015, p < 0.001 corrected for false discovery rate [FDR]) and nodal degree (F = 5.971, p FDR < 0.001) in the left middle occipital gyrus, as well as nodal efficiency (F = 6.930, p FDR < 0.001) and nodal degree (F = 5.884, p FDR < 0.001) in the left postcentral gyrus. We found no significant alterations in patients with major depressive disorder. Post hoc analyses revealed that compared with healthy controls, patients in the schizophrenia and bipolar disorder groups showed decreased global network efficiency, nodal efficiency and nodal degree in the left middle occipital gyrus. Furthermore, patients in the schizophrenia group showed decreased nodal efficiency and nodal degree in the left postcentral gyrus compared with healthy controls. Limitations: Our findings could have been confounded in part by treatment differences. Conclusion: Our findings implicate graded white matter network alterations across the 3 disorders, enhancing our understanding of shared and distinct pathophysiological mechanisms across diagnoses and providing vital insights into neuroimaging-based methods for diagnosis and research. to Fei Wang). The authors thank Dr.

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“…This CT increase is speculated to occur as a consequence of positive symptoms, which has been supported previously by findings of a positive correlation between post-central gyri-volumes and SAPS scores. 23 …”

Section: Discussionmentioning

confidence: 99%

Age-related cortical thickness trajectories in first episode psychosis patients presenting with early persistent negative symptoms

et al. 2016

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Recent work has clearly established that early persistent negative symptoms (ePNS) can be observed following a first episode of psychosis (FEP), and can negatively affect functional outcome. There is also evidence for cortical changes associated with ePNS. Given that a FEP often occurs during a period of ongoing complex brain development and maturation, neuroanatomical changes may have a specific age-related component. The current study examines cortical thickness (CT) and trajectories with age using longitudinal structural imaging. Structural T1 volumes were acquired at three time points for ePNS (N=21), PNS due to secondary factors (N=31), non-PNS (N=45) patients, and controls (N=48). Images were processed using the CIVET pipeline. Linear mixed models were applied to test for the main effects of (a) group, (b) time, and interactions between (c) time and group membership, and (d) age and group membership. Compared with the non-PNS and secondary PNS patient groups, the ePNS group showed cortical thinning over time in temporal regions and a thickening with age primarily in prefrontal areas. Early PNS patients also had significantly different linear and quadratic age relationships with CT compared with other groups within cingulate, prefrontal, and temporal cortices. The current study demonstrates that FEP patients with ePNS show significantly different CT trajectories with age. Increased CT may be indicative of disruptions in cortical maturation processes within higher-order brain regions. Individuals with ePNS underline a unique subgroup of FEP patients that are differentiated at the clinical level and who exhibit distinct neurobiological patterns compared with their non-PNS peers.

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A cross-sectional and longitudinal structural magnetic resonance imaging study of the post-central gyrus in first-episode schizophrenia patients

Cited by 20 publications

References 49 publications

Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases

Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases

Neurobiological commonalities and distinctions among 3 major psychiatric disorders: a graph theoretical analysis of the structural connectome

Age-related cortical thickness trajectories in first episode psychosis patients presenting with early persistent negative symptoms

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