Progression of diabetic retinopathy correlated with muscle perfusion disturbances of the lower limbs, with clinically important diagnostic recommendations

Tryniszewski, Wiesław; Gadzicki, Mariusz; Maziarz, Zbigniew; Kusmierczyk, Jaroslaw; Goś, Roman; Rysz, Jacek; Banach, Maciej

doi:10.5114/aoms.2010.19300

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Previous studies suggested that the progression of diabetic retinopathy correlated with muscle-perfusion disturbances of the lower limbs. 31–33 Consistent with these prior findings, our current data provided firsthand evidence that patients with muscle cramps showed a higher prevalence of DR and PDR, and that cramps were significantly associated with these two disorders. Intriguingly, we did not ascertain a relationship between NPDR and muscle cramps; the possible reason for this might be that the microvascular impairment of muscle in patients with NPDR was not as severe as in patients with PDR.…”

Section: Discussionsupporting

confidence: 91%

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Hu¹,

Wang²,

Liang³

et al. 2022

DMSO

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Aim Patients with type 2 diabetes (T2DM) often suffer from muscle cramps of varying severity. Studies have shown that muscle cramp is closely related to local microcirculation perfusion disorders. Diabetic retinopathy can not only reflect the microcirculation perfusion in the eye but also the systemic microcirculation in patients with diabetes. The aims of this study were to investigate the relationship between muscle cramps and diabetic retinopathy in patients with type 2 diabetes. Methods A total of 150 adult patients with type 2 diabetes were enrolled and administered a questionnaire on muscle cramping, along with a visual analogue scale for pain. Diabetic retinopathy (DR) was determined by using fundus photography and graded as non-proliferative DR (NPDR) and proliferative DR (PDR). To assess whether there was an association between the muscle cramps and diabetic retinopathy, we conducted binomial logistic regression analysis. Results Our study revealed that 48% of patients with T2DM experienced muscle cramps in the past three months. Patients self-reported suffering from muscle cramps exhibited a higher prevalence of DR (61% vs 38%, P < 0.05) and PDR (22% vs 4%, P < 0.05) compared with patients without muscle cramps. Serum 25-(OH) vitamin D, calcium, and magnesium levels were not significantly different between patients with and without muscle cramps. After adjusting for age, duration of diabetes, HbA1c, vitamin D, potassium, calcium, and magnesium, we demonstrated that diabetic retinopathy (OR, 2.18; 95% CI, 1.01–4.69; P< 0.05) and albumin (OR, 0.90; 95% CI, 0.82–1.00; P< 0.05) were highly associated with muscle cramps. Binomial logistic regression analysis also indicated that severity of DR is associated with muscle cramps. In addition, DR and PDR were found to be associated with muscle cramp frequency (P for trend < 0.05), duration (P for trend < 0.05), and pain severity (P for trend < 0.05). Conclusion Muscle cramps occur frequently in diabetes and are correlated with diabetic retinopathy and albumin. Patients with PDR exhibited a higher frequency, severity, and longer duration relative to those with NPDR or without DR. Our findings suggested that muscle cramps in individuals with T2DM might be a result of microvascular dysfunction. Modulation of microvascular perfusion might thus provide a therapeutic target for alleviating muscle cramps.

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Section: Discussionsupporting

confidence: 91%

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Hu¹,

Wang²,

Liang³

et al. 2022

DMSO

View full text Add to dashboard Cite

show abstract

“…This indicated that patients with abnormally low ABI have not only the kidneys at stake but also their vision 14 . Other studies have shown similar results indicating ABI as a marker of not only PAD but also diabetic retinopathy 15,16,17,18 . According to Joint Asia Diabetes Evaluation Program, 12,777 patients with type 2 diabetes had borderline ABI, which was associated with increased prevalence of microvascular complications.…”

Section: Discussionsupporting

confidence: 60%

Correlation of Ankle-Brachial Index with Diabetic Retinopathy in Patients of Type 2 Diabetes

Mazhar

Malik²,

Ali³

et al. 2020

pak J Ophthalmol

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Objectives: To find out a relationship of diabetic retinopathy with ankle-brachial (ABI) in patients of type 2 diabetes. Material and Methods It was a cross-sectional observational study carried out in Arif Memorial Teaching hospital and Rashid Latif Medical College from January 2019 to June 2019. 120 patients were selected by purposive convenient sampling from outpatient department of Arif Memorial Teaching hospital. After clinical history, complete ocular examination was performed. Random blood sugar levels were measured using Glucometer. Ankle-brachial index was calculated by dividing the systolic pressure at ankle by the systolic blood pressure at arm. Statistical analysis was done using SPSS 25. Independent sample t test and chi square tests were used to find out the significance of the results. Results: In this study of 120 diabetic patients, 80 (66.7%) were female and 40 (33.3%) were males. Mean Ankle Branchial Index (ABI) of Males was 0.96±0.11 and for females was 0.97±0.14.Among 120 participants of this study, 73 (60.83 %) patients had no signs of diabetic retinopathy, 35 (29.16 %) patients had NPDR and 12 (10%) patients had PDR. ABI was not associated with gender and duration of diabetes.However, there was negative and weak linear relationship between BSR and ABI (r= -0.221). This correlation was higher in diabetics of less than 5 year duration (r=-0.286) than in patients of more than 5 years duration of diabetes (r=-0.129). Conclusion: Our study indicates that ABI is not significantly related with diabetic retinopathy. However, there is a positive relationship of ABI with high blood sugar levels.

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“…Many factors have been identified for the cause of in-stent restenosis including; residual stenosis, stent fracture and stress, multiple stenting, long length of stent and lesion, diabetes and neoplasms. [38][39][40] Diabetes and its complications are important therapeutic problems in patient with vascular disease 41 . In the current study most of our patient has diabetes, therefore, high rates of restenosis can be expected in such cohort.…”

Section: Discussionmentioning

confidence: 99%

Midterm Outcomes after Primary Stenting in Treatment of Atherosclerotic Iliac Arteries

Atay

Saydam²,

Şerefli

et al. 2021

Arch Med Sci

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IntroductionThe purpose of this study was to report the midterm outcomes of primary stenting of iliac arteries with additional factors which affect the outcome and to compare the results between patients with simple and complex aorta iliac occlusive disease (AOID).Material and methodsFrom January 2015 and March 2018, the study consisted of 103 lesions in 93 patients with common iliac artery (CIA) and/or external iliac artery (EIA) lesions which accompanied with severe claudication or critical limb ischemia. Balloon-expandable stents (BMS), self-expandable stents (SES) and covered stents (CS) were used to treat the lesions.ResultsLesions of 93 patients that were in CIA and/or EIA and treated with ET were included to the study (n=103). Seventy-one (68.9%) lesions were classified as simple AIOD group (TASCII A-B) while 32(31.1%) were classified as complex AIOD (TASCII C-D) group. In 72.8% of the lesions only mild calcification was detected while 27.2% lesions had moderate or severe calcification. Mean stent diameter for CIA position was 8.26±0.8mm and for EIA position was 7.52±0.8mm. Mean lesion length in patients treated with BMS were 52.5±21.0mm while SES were 63.6±28.3(p=0.03). Technical success was achieved in 101(98.1%) lesions. Significant differences in primary (93% vs 63%) and secondary (98% vs 82%) patency rates at 24 months were found between patients in simple and complex AIOD group (p<0.001 p=0.001)ConclusionsConclusion: In our study, it was found that the primary stenting in patients who had AIOD had satisfactory results with high immediate success, low complication rates and acceptable midterm outcomes.

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Progression of diabetic retinopathy correlated with muscle perfusion disturbances of the lower limbs, with clinically important diagnostic recommendations

Cited by 5 publications

References 13 publications

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Relationship Between Muscle Cramps and Diabetic Retinopathy in Patients with Type 2 Diabetes

Correlation of Ankle-Brachial Index with Diabetic Retinopathy in Patients of Type 2 Diabetes

Midterm Outcomes after Primary Stenting in Treatment of Atherosclerotic Iliac Arteries

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