Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Fathil, M. F. M.; Arshad, M. K. Md; Ruslinda, A. Rahim; Gopinath, Subash C. B.; Adzhri, R.; Hashim, U.

doi:10.1016/j.aca.2016.06.012

Cited by 29 publications

(7 citation statements)

References 90 publications

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“…However, the high consumption of human resources, time, and money limited its expansion in community clinics. 150 Besides, the risky concentration of cTnI is lower than the normal detection limit. Based on that, the high area to volume ratio makes nanomaterials conjugate with more capture antibodies, thus enhancing the combined cTnI in the blood sample.…”

Section: Discussionmentioning

confidence: 99%

New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials

Shi

Huang

et al. 2022

eBioMedicine

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Section: Discussionmentioning

confidence: 99%

New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials

Shi

Huang

et al. 2022

eBioMedicine

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“…Although these techniques have demonstrated powerful trace analysis with high sensitively and excellent reproducibility, but there are some drawbacks including time consuming, sophisticated equipment and long sample preparation process which are defense the on-situ and real time detection [14]. Thus, in recent years, alternative ways for the detection of the pesticide has been illustrated such as Capacitive-based sensors [15]- [18], field effect transistor (FET) based sensors [19], [20] Micro-Electro-Mechanical systems (MEMS) [21], Quartz Crystal Microbalance (QCM) [8], [22], [23] and Film Bulk Acoustic Resonator (FBAR) [24], [25]. In this review, we investigate and discuss the current techniques used for chemicals and pesticides detection, taking into account the use of recognitions elements, including the enzymes, antibodies, aptamers, and molecular imprinted polymers.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Development of Biosensors for Chemicals and Pesticides Detection

et al. 2020

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Chemicals and pesticides contamination in the food, drinking water, and environment ecosystem have become one of the most serious problems for human public health in the world due to their large amount used and wide application in the agriculture industry. Therefore, the detection and analysis of contamination in the food and drinking water by using techniques that are simple and suitable for fast screening are important. This review gives an overview of the last trends and recent advances biosensors for chemicals and pesticides detection based on electrochemical, optical and mechanical transducers strategies. Furthermore, the biosensors are classified according to their immobilized biorecognition elements including aptamer, antibodies, enzymes, and molecularly imprinted polymers. The implementation of nanomaterials such as graphene, carbon nanotubes, and metals nanoparticles are also emphasized and discussed in this review, these nanomaterials provides remarkable features to the biosensors such highly sensitive and accurate which allowing efficient pesticides detection. In addition to highlighting and summarizing various novel sensors, this review also provided some drawbacks, challenging, prospects as well as the current efforts to enhanced optical sensors. INDEX TERMS Biosensors, chemical detection, electrochemical transducer, mechanical transducer, optical transducer, pesticides detection.

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“…7. Progression of cTn biomarkers devices detection from the past, present, and future perspective, a transition from benchtop towards translational research [33].…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

FET-biosensor for cardiac troponin biomarker

2017

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Abstract. Acute myocardial infarction or myocardial infarction (MI) is a major health problem, due to diminished flow of blood to the heart, leads to higher rates of mortality and morbidity. The most specific markers for cardiac injury are cardiac troponin I (cTnI) and cardiac troponin T (cTnT) which have been considered as 'gold standard'. Due to higher specificity, determination of the level of cardiac troponins became a predominant indicator for MI. Currently, field-effect transistor (FET)-based biosensors have been main interest to be implemented in portable sensors with the ultimate application in point-of-care testing (POCT). In this paper, we review on the FET-based biosensor based on its principle of operation, integration with nanomaterial, surface functionalization as well as immobilization, and the introduction of additional gate (for ambipolar conduction) on the device architecture for the detection of cardiac troponin I (cTnI) biomarker.

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Progression in sensing cardiac troponin biomarker charge transductions on semiconducting nanomaterials

Cited by 29 publications

References 90 publications

New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials

New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials

Recent Progress in the Development of Biosensors for Chemicals and Pesticides Detection

FET-biosensor for cardiac troponin biomarker

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