Progresses and Challenges of Omics Studies and Their Impacts in Personalized Medicine

Bencharit, Sompop

doi:10.4172/2153-0645.1000e105

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Similar study designs should be considered to see if salivary proteins can be detected in adverse reaction to orthodontic treatment . In the future, personalized orthodontics may provide use of point‐of‐care salivary biomarker detection system …”

Section: Discussionmentioning

confidence: 99%

“…26 In the future, personalized orthodontics may provide use of point-of-care salivary biomarker detection system. 27 It is also important to note the limitation of this systematic review, which only selected studies that included proteins in saliva as well as identified protein markers. The limitations included articles that were excluded at the final stage, the grey literature/publication bias and the heterogeneity of the study subjects.…”

Section: Discussionmentioning

confidence: 99%

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Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

Allen

Edelmann

Abdulmajeed

et al. 2019

Orthod Craniofacial Res

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Structured Abstract Objective Saliva can provide a non‐invasive approach to indicate changes in the oral and systemic conditions. Salivary proteomics allows the discovery of new protein biomarkers associated with certain conditions. The effectiveness and physiological effects of orthodontic tooth movement in theory can be measured using salivary protein biomarkers. Setting and Sample Population This study applied a systematic review to analyse current literature to define and summarize salivary biomarkers associated with orthodontic tooth movement identified by mass spectrometry proteomics and other protein detection techniques. Materials and Methods Peer‐reviewed articles published through the 15th of November 2018 via the PubMed, EMBASE, Web of Science and Dentistry & Oral Sciences databases were reviewed. Only studies analysing protein biomarkers in saliva samples collected from human subjects associated with orthodontic treatments were included. Results Out of 482 articles, 7 studies were selected. Sample size ranged from 3 to 72 subjects. Minor variations of unstimulated whole saliva sample collection protocol were noted. Mass spectrometry proteomics and ELISA represented the majority of biomarker discovery and targeting, respectively. Twenty biomarkers were identified or chosen as target biomarkers. Conclusion Salivary proteins may be used to indicate effectiveness of orthodontic treatment and orthognathic treatment as well as adverse treatment consequence, such as root resorption.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%