Progress in understanding the role of lncRNA in programmed cell death

Jiang, Na; Zhang, Xiaoyu; Gu, Xuejun; Li, Xiaozhuang; Shang, Lei

doi:10.1038/s41420-021-00407-1

Cited by 128 publications

(99 citation statements)

References 93 publications

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“…Moreover, various types of RCD mechanisms have recently been identified along with conventional RCD mechanisms, such as apoptosis [ 174 ]. Moreover, RCDs can play an important role in skin.…”

Section: Signals and Signaling Pathways In Hfscsmentioning

confidence: 99%

A systematic summary of survival and death signalling during the life of hair follicle stem cells

Zhang

et al. 2021

Stem Cell Res Ther

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Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult stem cells. HFSCs are particularly useful because of their self-renewal and differentiation properties. Additionally, the cyclic growth of hair follicles is driven by HFSCs. There are high expectations for the use of HFSCs as favourable systems for studying the molecular mechanisms that contribute to HFSC identification and can be applied to hair loss therapy, such as the activation or regeneration of hair follicles, and to the generation of hair using a tissue-engineering strategy. A variety of molecules are involved in the networks that critically regulate the fate of HFSCs, such as factors in hair follicle growth and development (in the Wnt pathway, Sonic hedgehog pathway, Notch pathway, and BMP pathway), and that suppress apoptotic cues (the apoptosis pathway). Here, we review the life cycle, biomarkers and functions of HFSCs, concluding with a summary of the signalling pathways involved in HFSC fate for promoting better understanding of the pathophysiological changes in the HFSC niche. Importantly, we highlight the potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing.

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Section: Signals and Signaling Pathways In Hfscsmentioning

confidence: 99%

A systematic summary of survival and death signalling during the life of hair follicle stem cells

Zhang

et al. 2021

Stem Cell Res Ther

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“…Several lines of evidence have shown that lncRNAs are capable of influencing different cellular functions that are critical to tumorigenesis, such as cell proliferation, differentiation, migration, immune response, and apoptosis [41][42][43][44][45][46][47]. Furthermore, lncRNAs have been found to act as tumor suppressors or oncogenes [48][49][50][51], and, of note, a number of lncRNAs have been reported to be significantly deregulated in tumors [52][53][54][55].…”

Section: Long Non-coding Rna Structures and Functionsmentioning

confidence: 99%

Circulating Long Non-Coding RNAs as Novel Potential Biomarkers for Osteogenic Sarcoma

Moonmuang

Chaiyawat

Jantrapirom

et al. 2021

Cancers

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Circulating cell-free nucleic acids recently became attractive targets to develop non-invasive diagnostic tools for cancer detection. Along with DNA and mRNAs, transcripts lacking coding potential (non-coding RNAs, ncRNAs) directly involved in the process of tumor pathogenesis have been recently detected in liquid biopsies. Interestingly, circulating ncRNAs exhibit specific expression patterns associated with cancer and suggest their role as novel biomarkers. However, the potential of circulating long ncRNAs (c-lncRNAs) to be markers in osteosarcoma (OS) is still elusive. In this study we performed a systematic review to identify thirteen c-lncRNAs whose altered expression in blood associate with OS. We herein discuss the potential impact that these c-lncRNAs may have on clinical decision-making in the management of OS. Overall, we aimed to provide novel insights that can contribute to the development of future precision medicine in oncology.

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“…lncRNAs play an important role in many life activities, such as epigenetic regulation, cell cycle regulation, and regulation of cell differentiation [ 10 ]. In particular, the abnormal function or expression of lncRNA may be closely related to various biological processes, including ferroptosis [ 11 ]. For example, the lncRNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competitive endogenous RNA [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of seven novel ferroptosis-related long non-coding RNA signatures as a diagnostic biomarker for acute myeloid leukemia

Zheng

Lin

et al. 2021

BMC Med Genomics

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Background Ferroptosis is a newly discovered type of programmed cell death that participates in the biological processes of various cancers. However, the mechanism by which ferroptosis modulates acute myeloid leukemia (AML) remains unclear. This study aimed to investigate the role of ferroptosis-related long non-coding RNAs (lncRNAs) in AML and establish a corresponding prognostic model. Methods RNA-sequencing data and clinicopathological characteristics were obtained from The Cancer Genome Atlas database, and ferroptosis-related genes were obtained from the FerrDb database. The “limma” R package, Cox regression, and the least absolute shrinkage and selection operator were used to determine the ferroptosis-related lncRNA signature with the lowest Akaike information criteria (AIC). The risk score of ferroptosis-related lncRNAs was calculated and patients with AML were divided into high- and low-risk groups based on the median risk score. The Kaplan–Meier curve and Cox regression were used to evaluate the prognostic value of the risk score. Finally, gene set enrichment analysis (GSEA) and single-sample gene set enrichment analysis (ssGSEA) were performed to explore the biological functions of the ferroptosis-related lncRNAs. Results Seven ferroptosis-related lncRNA signatures were identified in the training group, and Kaplan–Meier and Cox regression analyses confirmed that risk scores were independent prognostic predictors of AML in both the training and validation groups (All P < 0.05). In addition, the area under the curve (AUC) analysis confirmed that the signatures had a good predictive ability for the prognosis of AML. GSEA and ssGSEA showed that the seven ferroptosis-related lncRNAs were related to glutathione metabolism and tumor immunity. Conclusions In this study, seven novel ferroptosis-related lncRNA signatures (AP001266.2, AC133961.1, AF064858.3, AC007383.2, AC008906.1, AC026771.1, and KIF26B-AS1) were established. These signatures were shown to accurately predict the prognosis of AML, which would provide new insights into strategies for the development of new AML therapies.

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Progress in understanding the role of lncRNA in programmed cell death

Cited by 128 publications

References 93 publications

A systematic summary of survival and death signalling during the life of hair follicle stem cells

A systematic summary of survival and death signalling during the life of hair follicle stem cells

Circulating Long Non-Coding RNAs as Novel Potential Biomarkers for Osteogenic Sarcoma

Identification of seven novel ferroptosis-related long non-coding RNA signatures as a diagnostic biomarker for acute myeloid leukemia

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