Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering

Abstract

The discovery of novel methods to fabricate optimal scaffolds that mimic both mechanical and functional properties of the extracellular matrix (ECM) has always been the “holy grail” in tissue engineering.

Nanoengineered electrospun fibers and their biomedical applications: a review

“…However, from the perspective of biomimicry, it is difficult for single-component electrospun fibers to achieve the biomimetic properties of ECM. Nanocomposite electrospun fibers incorporating organic and inorganic nanoparticles like zincoxide, graphene oxide, hydroxyl apatite or cellulose nanocrystals have all been used with the aim to enhance properties of scaffolds for tissue engineering [156]. However, challenges in nanoparticle enhanced fibers still remain in achieving homogeneous dispersions and good alignment of 1D or 2D nanoparticles, especially at high filler concentrations.…”

Diamond in medical devices and sensors: An overview of diamond surfaces

“…Both forms of ND-composite have shown enhancement in mechanical properties and effectively support cell adhesion and growth (Ahn et al, 2018;Houshyar et al, 2019Houshyar et al, , 2020Nistor & May, 2017a). ND-loaded nanofibrous scaffolds also show improved growth and adhesion of cells when compared to thin films, as the cells are highly sensitive to the physical properties of the underlying scaffold (Kromka et al, 2010;Nistor & May, 2017a (Gao et al, 2019).…”

“…The ND‐loaded nanfibre scaffolds are suitable for tissue engineering as they have large surface area and a high aspect ratio coupled with small pore structures. They have desirable properties for scaffolds of extracellular matrix (ECM) analogues, including their topological structure which can imitate the ECM to enhance cell migration and proliferation (Gao et al, 2019).…”

“…ND‐modified nanofibre scaffolds have also been used for drug delivery with better efficacy and safety in comparison with existing drug delivery systems. This is due to the mechanical properties and surface functional groups of NDs, which provide the ability to create a multifunctional‐specific scaffold for delivering the drug to a specific site (Gao et al, 2019; Pramatarova, 2011; Qian et al, 2019; Rehman et al, 2020). In a different study, ND‐doxorubicin complexes were used to treat drug‐resistant breast and liver cancers in a model (Locharoenrat, 2019).…”

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

“…Acknowledging the beneficial features, the electrospun nanofibers offers great possibility in the regeneration of various tissues in the human body as depicted in the Figure 7 [101]. Therefore, to date enormous progress have shown that the electrospun based scaffolds are greatly enhanced the repair/regeneration of different of tissues (e.g., bone, skin, nerve, heart, vascular and muscoskeletal system) due to its inherent properties of large surface area, porosity, stacking/pattering nature, alignment, mechanical strength, complex interface topology and easy functionalization nature [31,47,[102][103][104][105][106][107][108]. Therefore, we evidently discuss potential of electrospun nanofibers in the engineering of various tissues in the following sections.…”