Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury

Abstract

Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day. The RDW, PLT, and RPR values on the 3rd and 7th day were significantly associated with the outcomes of severe burn patients (P < 0.01). High RPR was significantly associated with a 90-day mortality rate at the two time points. However, the RDW and PLT did not provide independent predictive values. Our results indicated that the RPR values on the 3rd and 7th day were associated with the mortality rates of severe burn patients (P < 0.01). Meanwhile, the RDW and PLT values at these time points failed to provide independent values for burn mortality prediction. Thus, the RPR can serve as an independent and novel marker for mortality rates prediction in severe burn patients.

<p>The Association of Red Blood Cell Distribution Width to Platelet Count Ratio and 28-Day Mortality of Patients with Sepsis: A Retrospective Cohort Study</p>

“…Celik et al 31 reported that admission RPR dependently correlated with the no-reflow phenomenon in patients who were diagnosed with myocardial infarction and had undergone a primary percutaneous coronary intervention. Besides, RPR showed good predictive ability for mortality of acute pancreatitis and severe burn injury, 14,32 which are common causes of sepsis. Therefore, we hypothesized RPR also related to sepsis.…”

Red Cell Distribution Width to Platelet Count Ratio as a Promising Indicator of Mortality for Acute Traumatic Brain Injury: a Study on Large ICU&nbsp;Cohorts

“…As a routinely available marker, RPR was recognized as a strong predictor for hepatic brosis and hepatitis [31,32], in ammation in acute pancreatitis [33], ascending thoracic aortic aneurysm [34], and myocardial infarction [35]. In addition, high RPR on days 3 and 7 could be observed in patients with severe burn injury, which indicated poor prognosis of the disease [36]. Parallel to these studies, the increased RPR was also reported to be correlated with the severity (disease scores) of in ammatory factors in systemic lupus erythematosus [37].…”

The Value of Neutrophil to Lymphocyte Ratio, Platelet Count and Red Cell Distribution Width to Platelet Ratio as Prognostic Markers in Burn Patients

“…Moreover platelet count was also found to be lower in the mortality group. On extended search of literature we could find only one study done by Li Qui et al [24] that studied its role in prognosis of burn patients. Li Qui et al's study established that a higher RPR value is seen in patients with severe burn and such patients have a poorer prognosis.…”