2020
DOI: 10.2147/tcrm.s268523
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<p>The Association of Red Blood Cell Distribution Width to Platelet Count Ratio and 28-Day Mortality of Patients with Sepsis: A Retrospective Cohort Study</p>

Abstract: Background: Sepsis is a life-threatening and inflammatory disease with high morbidity and mortality. Red blood cell distribution width to platelet count ratio (RPR) was known as an inflammatory biomarker and was related to poor outcomes of various diseases. Aim: This study was intended to explore the association between RPR and mortality of sepsis patients. Methods: A retrospective cohort study was undertaken in patients with sepsis, and the data were collected from a public database called Medical Information… Show more

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Cited by 13 publications
(24 citation statements)
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References 34 publications
(36 reference statements)
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“…In addition, RPR also showed good predictive ability for mortality in patients with sepsis, breast cancer, severe burn injury and neonates. 21–23 46 Similarly, our study is consistent with previous results. In this study, we found that RPR was an independent predictor of in-hospital mortalityin critically ill patients with AMI.…”
Section: Discussionsupporting
confidence: 93%
“…In addition, RPR also showed good predictive ability for mortality in patients with sepsis, breast cancer, severe burn injury and neonates. 21–23 46 Similarly, our study is consistent with previous results. In this study, we found that RPR was an independent predictor of in-hospital mortalityin critically ill patients with AMI.…”
Section: Discussionsupporting
confidence: 93%
“…Ge et al revealed that the basal RPR is associated with an increased risk of death in individuals with sepsis, 18 consistent with our findings. The study measured RPR only once; however, in our study, an increased amplitude in RPR was used as exposure of interest.…”
Section: Discussionsupporting
confidence: 93%
“…The severity of the inflammatory response is considered to be reflected by a single RPR at baseline, which can be used to predict the sepsis-related adverse outcomes. 18 According to the two previous studies, RPR has a significant diagnostic and prognostic potential in paediatric and neonatal sepsis. 19 20 Furthermore, baseline RPR has been recommended as a potentially valuable prognostic index for breast cancer, 21 liver fibrosis, 22 severe burn injuries 23 and deep-seated intracerebral bleeding.…”
Section: Introductionmentioning
confidence: 97%
“…In the inflammatory process, in addition to sepsis-related anemic events, inflammatory cytokines may inhibit the maturation of RBCs and thus alter the RDW ( 32 ) whereas platelets are known to be placed on the intersection of an immune response and coagulation in infectious diseases ( 33 ). Thus, a marker as RPR, which takes into account both potential reflections of the inflammatory process, may be more accurate than non-specific markers such as CRP ( 34 , 35 ). Also, in the anticipation of further complications in the course of treatment of ICH (e.g., renal replacement therapy), non-specific markers such as CRP have been reported to be less predictive than those that are considered more specific for inflammatory processes, such as PCT ( 6 ).…”
Section: Discussionmentioning
confidence: 99%