Prognostic Value of the Modified Systemic Inﬂammation Score in Patients With Extranodal Natural Killer/T-Cell Lymphoma

Huang, He; Chen, Li Min; Fang, Xiao Jie; Guo, Cheng; Lin, Xiao; Huang, Hong; Li, Xi; Wang, Zhao; Tian, Ying; Chen, Mei Ting; Yao, Y.; Chen, Zegeng; Li, Xiao Qian; Pan, Fei

doi:10.3389/fphar.2020.593392

Cited by 20 publications

(23 citation statements)

References 40 publications

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“…The mSIS was modified from the SIS to include a fixed value of 3.4 for the LMR as opposed to the median. Recently, more scholars have adopted the mSIS ( 7 , 8 , 23 , 26 ). We found that the mSIS was significantly correlated with postoperative unplanned admission to the ICU in patients with NSCLC, especially in patients with a mSIS of 2 (ALB < 4.0 g/d and LMR < 3.4).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of modified systemic inflammation score for postoperative unplanned ICU admission in patients with NSCLC

Wang

Zhang²,

Huang³

et al. 2022

Front. Surg.

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BackgroundThe purpose of this study was to investigate the predictive value of the modified systemic inflammation score (mSIS) in postoperative unplanned admission to the intensive care unit (ICU) in patients with non-small-cell lung cancer (NSCLC).MethodsThe clinical data of 1,321 patients with NSCLC treated with thoracic surgery in our hospital from August 2019 to June 2021 were analyzed retrospectively. The preoperative mSIS, which takes into account the serum albumin (ALB) level and lymphocyte-to-monocyte ratio (LMR), was recorded as 0, 1 or 2 and then was used to identify high-risk patients with unplanned admission to the ICU. The independent risk factors for unplanned admission to the ICU in patients with NSCLC after surgery were identified by multivariate logistic regression analysis.ResultsA total of 1,321 patients, including 549 (41.6%) males and 772 (58.4%) females, were included. The median age was 57 years (range 16–95 years). The incidence of unplanned admission to the ICU in patients with mSIS = 2 was significantly higher than that in those with mSIS = 0 and mSIS = 1. The multivariate analysis showed that an mSIS of 2 (OR = 3.728; P = 0.004; 95% CI, 1.520–9.143), an alcohol consumption history (OR = 2.791, P = 0.011; 95% CI, 1.262–6.171), intraoperative infusion volume (OR = 1.001, P = 0.021; 95% CI, 1.000–1.001) and preoperative underlying diseases (OR = 3. 57, P = 0.004; 95% CI, 1.497–8.552) were independent risk factors for unplanned admission to the ICU after lung cancer surgery. In addition, the multivariate logistic regression model showed that the C-statistic value was 0.799 (95% CI: 0.726∼0.872, P < 0.001).ConclusionsThe mSIS scoring system can be used as a simplified and effective predictive tool for unplanned ICU admission in patients with NSCLC.

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Section: Discussionmentioning

confidence: 99%

Predictive value of modified systemic inflammation score for postoperative unplanned ICU admission in patients with NSCLC

Wang

Zhang²,

Huang³

et al. 2022

Front. Surg.

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“…Recently, many studies have reported that mSIS, which is determined according to the LMR and serum albumin concentration before surgery, is the new inflammation-related prognosis scoring system. Researchers have identified that mSIS is of prognostic value for GC, lymphoma, and ESCC ( 12 – 14 ). It takes into account the effects of systemic inflammation together with the nutritional status on cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Galizia et al have first reported that a new scoring system according to the LMR and albumin concentration in serum, which was called the modified systemic inflammation score (mSIS) and it might comprehensively reflect nutritional status and systemic inflammation in patients with cancer (11). The mSIS was strongly related to the survival for patients with GC, esophageal squamous cell carcinoma (ESCC), and lymphoma (12)(13)(14). Besides, it is suggested that, compared with other prognostic factors, including the modified Glasgow Prognostic Score and the original systemic inflammation score, the mSIS is more accurate in predicting survival (12,13).…”

Section: Introductionmentioning

confidence: 99%

Modified Systemic Inflammation Score Is an Independent Predictor of Long-Term Outcome in Patients Undergoing Surgery for Adenocarcinoma of the Esophagogastric Junction

Xiong

Kang²,

Ma³

et al. 2021

Front. Surg.

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Background: The modified systemic inflammation score (mSIS), which is calculated by a composite score of the lymphocyte-to-monocyte ratio and the albumin content in serum, is identified as the new score to predict the prognosis for various cancers. However, its significance for patients with adenocarcinoma of esophagogastric junction (AEJ), who receive surgery, remains unclear.Methods: This study retrospectively analyzed 317 patients with AEJ receiving surgery between September 2010 and December 2016. The associations between the mSIS and the clinicopathological features, overall survival (OS), as well as relapse-free survival (RFS), were assessed. In addition, the time-dependent receiver operating characteristic (t-ROC) curve analysis was performed for comparing the value of those scoring systems in predicting patient prognosis.Results: Of the 317 cases, 119 were rated as mSIS 0, 123 as mSIS 1, and 75 as mSIS 2. Besides, mSIS was significantly related to age and tumor size. On multivariate analysis, mSIS was identified as a predictor to independently predict OS (p < 0.001) along with RFS (p < 0.001), and a significantly strong correlation was observed at the advanced pTNM stages based on the mSIS system. In the subgroup analysis of adjuvant chemotherapy and surgery alone, mSIS was still the predictor for independently predicting patient OS (p < 0.001) together with RFS (p < 0.001) for the two groups. T-ROC analysis showed that mSIS was more accurate than controlling nutritional status score in predicting OS and RFS.Conclusions: The mSIS can serve as an easy, useful scoring system to independently predict the preoperative survival for AEJ cases undergoing surgery.

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“…The important issue here is which factor should be added to the traditional inflammatory parameters for mSIS. While Chang et al used Alb for modification, Huang He et al used CRP [ 20 ]. Both of these two parameters have been recently been added to the SIS scoring system.…”

Section: Dıscussıonmentioning

confidence: 99%

The diagnostic value of modified systemic ınflammation score in predicting post-operative outcomes of cutaneous melanoma patients who underwent ısolated limb perfusion

et al. 2021

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Background In-transit metastasis is considered a locoregional disease in cutaneous melanoma (CM) patients. Isolated limb perfusion (ILP) is among the treatment options in selected cases. The aim of this study was to determine the success of pre- and post-perfusion mSIS values in predicting the potential complications and the prognosis of the disease by investigating the early and long-term results of mSIS values calculated before and after ILP in CM cases with in-transit metastases. Materials and methods Patients who underwent ILP within the period from 2014 to 2020 in our department were retrospectively scanned. A total of 20 patients were found to undergo ILP. The scores obtained from modified inflammation score (mSIS) were formulated according to albumin (Alb) and lymphocyte to monocyte ratio (LMR) scores. Results The mean follow-up time was 20.47 months. Complications requiring surgical intervention developed in three patients. According to the Wieberdink local toxicity classification, the majority (70%) of the patients were found to be grade II. Based on pre-perfusion mSIS values, 8 patients were classified as mSIS 0 while six patients were classified as mSIS 1 and 2. Based on post-perfusion mSIS values, 14 patients and one patient were classified as mSIS 2 (70%) and mSIS 0, respectively. Accordingly, univariate analysis showed that mSIS 1 and mSIS 2 were negative prognostic factors for mean survival in the pre-perfusion period (HR 0.162, 95% CI 0.036–0.729; p = 0.018 and HR: 0.223, 95% CI 0.049–1.019; p = 0.053) whereas albumin (Alb) and lymphocyte to monocyte ratio (LMR) were not independent prognostic factors for mean survival. Conclusion The mSIS values calculated in the pre-perfusion period can give an opinion about the OS of the patients whereas post-perfusion mSIS values may predict potential surgical complications and local toxicities.

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Prognostic Value of the Modified Systemic Inﬂammation Score in Patients With Extranodal Natural Killer/T-Cell Lymphoma

Cited by 20 publications

References 40 publications

Predictive value of modified systemic inflammation score for postoperative unplanned ICU admission in patients with NSCLC

Predictive value of modified systemic inflammation score for postoperative unplanned ICU admission in patients with NSCLC

Modified Systemic Inflammation Score Is an Independent Predictor of Long-Term Outcome in Patients Undergoing Surgery for Adenocarcinoma of the Esophagogastric Junction

The diagnostic value of modified systemic ınflammation score in predicting post-operative outcomes of cutaneous melanoma patients who underwent ısolated limb perfusion

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