Prognostic value of platelet/lymphocyte ratio and CAMI-STEMI score for major adverse cardiac events in patients with acute ST segment elevation myocardial infarction after percutaneous coronary intervention

Abstract

The aim of this study was to investigate the predictive value of the platelet-to-lymphocyte ratio (PLR) and the China Acute Myocardial Infarction registry-ST segment elevation myocardial infarction (CAMI-STEMI) score for major adverse cardiovascular events (MACE) in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) within 6 months.We enrolled STEMI patients who received emergency PCI in the First Hospital of Lianyungang from January 2016 to December 2019. The clinical characteristics of the patients, the PLR, and the CAMI-STEMI score were recorded. The MACE included heart failure, nonfatal re-infarction, recurrent angina pain, re-hospitalization for cardiovascular-related illness, repeat PCI, coronary artery bypass grafting, and all-cause mortality. According to the incidence of MACE during the follow-up the patients were divided into the MACE group (96 cases, 24.8%) and the non-MACE group (291 cases, 75.2%).The PLR, 147.62 (121.13–205.20) in MACE group, was 111.19 (90.23–146.42) in the non-MACE group in comparison, the PLR was higher in MACE group than that in non-MACE group (P < .01). Multivariate regression analysis showed that PLR (odds ratio (OR) = 1.007, 95% confidence interval (CI) 1.002–1.012, P < .01) and CAMI-STEMI score (OR = 1.575, 95% CI: 1.311–1.892, P < .01) were independent predictors of MACE. Besides, I-BIL was also an independent predictor of MACE (OR = 1.007, 95% CI: 1.011–1.146, P = .021). Reciever-operating characteristic curve showed that the area under curve of PLR was 0.704 (95%CI 0.644–0.763, P < .001). The cutoff value was 112.6, the sensitivity and specificity were 84.4% and 51.9%, respectively.PLR and CAMI-STEMI scores were independent risk factors of MACE after PCI in STEMI patients.

Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

“…Wang et al reported that PLR could predict major adverse cardiac events (MACE) at long-term follow-up in patients with STEMI undergoing percutaneous coronary intervention (PCI) [ 66 ]. PLR was significantly high in the MACE group (147.62 in the MACE group and 111.19 in the non-MACE group).…”

Association of Neutrophil to Lymphocyte Ratio With Plaque Rupture in Acute Coronary Syndrome Patients With Only Intermediate Coronary Artery Lesions Assessed by Optical Coherence Tomography

“…PLR dramatically increased in plaque rupture group while PDW and MPV remained unchanged. Unfortunately, PLR was not closely related to plaque rupture in intermediate lesions analyzed by multivariate analysis although it has been suggested to have a prognostic value in ACS patients (24,25). On the other hand, it is worth emphasizing that EDTA, an anticoagulant used in blood sample collection may induce platelet swelling and thus increasing the value of PDW and MPV (26).…”

The Prognostic Significance of Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR) and Platelet to Lymphocyte Ratio (PLR) on Long-Term Survival in Off-Pump Coronary Artery Bypass Grafting (OPCAB) Procedures

“…In patients with STEMI treated with coronary angioplasty, PLR was a no-reflow phenomenon predictor [ 87 ] and long-term mortality [ 88 ]. The usage of PLR, obtained before angioplasty, for adverse events and long-term mortality prediction, has been reported [ 89 , 90 , 91 , 92 ]. Qiu et al [ 85 ] performed a meta-analysis of 14 studies presenting an association between PLR and chronic coronary syndrome.…”