Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Seo, In-Ho; Lee, Yong-Jae

doi:10.3390/biomedicines10112697

Cited by 24 publications

(10 citation statements)

References 80 publications

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“…33 Particularly, emerging evidence suggests that PLR has also been proposed as a marker for kidney diseases. 34 In this study, we found that the patients with poor treatment effects, whose serum ALB levels were less than 30g/L at 6 months or who did not reach CR at the end of the follow-up, had numerically higher PLR. Especially for patients with CR or not, the difference was near to statistic significant.…”

Section: Discussionmentioning

confidence: 54%

The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study

Zhang¹,

Dai²,

Zhang³

et al. 2023

JIR

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Background: Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients continue to progress and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the major antigen of PMN, the clinical features do not often parallel with the antibody titers. Therefore, it is significant to find relative credible markers to predict the treatment response. Methods: One hundred and eighteen PMN patients were recruited. The response to treatment was defined as ALB≥30g/L at 6 months and complete remission (CR) or not at the end of the follow-up. Renal outcome endpoint was defined as 50% or more Cr increase at the end. Results: The patients with poor treatment effects had numerically higher platelet-lymphocytes ratio (PLR). For patients with CR or not, the difference was near to statistic significant (P=0.095). When analyzing CR or not, the fitting of the binary logistic regression model including both PLA2R Ab titer and PLR (Hosmer-Lemeshow test: χ 2 =8.328, P = 0.402; OR (PLA2R Ab titer) = 1.002 (95% CI 1.000-1.004, P = 0.042); OR (PLR) = 1.006 (95% CI 0.999-1.013, P = 0.098)) was markedly better than that with only PLA2R Ab titer (Hosmer-Lemeshow test: χ 2 =13.885, P = 0.016). The patients with renal function deterioration showed significantly higher monocyte-lymphocyte ratio (MLR) (0.26 (0.22-0.31) vs 0.18 (0.13-0.22), P = 0.012). Conclusion: PMN patients with poor treatment response tended to have higher PLR at the time of renal biopsy, and a higher MLR was associated with poor renal outcomes. Our findings suggested that PLR and MLR might be used to predict treatment efficacy and prognosis for PMN patients, respectively.

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Section: Discussionmentioning

confidence: 54%

The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study

Zhang¹,

Dai²,

Zhang³

et al. 2023

JIR

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“…Some studies showed that PLR could be potentially valuable in the accurate evaluation of in ammatory activity [14] , and others demonstrated that high PLR was associated with venous thrombosis [25] . Particularly, emerging evidence suggests that PLR has also been proposed as a marker for kidney diseases [15] . In this study, we found that the patients with poor treatment effects, whose serum ALB levels were less than 30g/L at 6 months or who didn't reach CR at the end of the follow-up, had numerically higher PLR.…”

Section: Discussionmentioning

confidence: 99%

“…These monocytes differentiate into macrophages and create an in ammatory state [15] . Some kidney macrophages have been demonstrated to be able to promote kidney brosis [28] .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have found that the ratios of different blood cell components are new in ammatory and immunoreactive markers, such as neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocytes ratio (PLR), and systemic immune-in ammation index (SII, calculated by platelet count × neutrophil count/lymphocyte count), which have good predictive value in the outcome of cancer, chronic kidney disease, cardiovascular disease, rheumatic disease, type 2 diabetes, metabolic syndrome, and so on [10][11][12][13][14][15][16][17] . To our knowledge, limited studies have focused on evaluating the involvement of these markers in PMN, as well as their predictive value for treatment and progression in PMN.…”

Section: Introductionmentioning

confidence: 99%

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The value of peripheral blood cell ratios in primary membranous nephropathy

Zhang

Dai

Zhang

et al. 2023

Preprint

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Background Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients still continue to progress and worsen and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the major antigen of PMN in adults, the clinical features don’t often parallel with the antibody titers. Therefore, it is significant to find relative credible markers to predict the treatment response in patients with PMN. Methods In this study, 118 patients with PMN were recruited. The response to treatment was defined as ALB≥30g/L at 6 months and complete remission (CR) or not at the end of the follow-up visit. Renal outcome endpoint was defined as 50% or more Cr increase at the end. Results The patients with poor treatment effects had numerically higher platelet-lymphocytes ratio (PLR). Especially for patients with CR or not, the difference was near to statistic significant (P=0.095). It is noteworthy that when analyzing CR or not, the fitting of the binary logistic regression model including both PLA2R Ab titer and PLR (Hosmer-Lemeshow test: χ2=8.328, P=0.402; OR (PLA2R Ab titer) =1.002 (95% CI 1.000-1.004, P=0.042); OR (PLR) =1.006 (95% CI 0.999-1.013, P=0.098) was markedly better than that with only PLA2R Ab titer (Hosmer-Lemeshow test: χ2=13.885, P=0.016). The patients with renal function deterioration showed significantly higher monocyte-lymphocyte ratio (MLR) (0.26 (0.22-0.31) vs 0.18 (0.13-0.22), P=0.012). Conclusion PMN patients with poor treatment response tended to have higher PLR at the time of renal biopsy, and a higher MLR was associated with poor renal outcomes. Our findings suggested that PLR and MLR might be used to predict treatment efficacy and prognosis for PMN patients, respectively.

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“…These leukocyte-derived indices integrate information from the innate and adaptive immunity to avoid relying on the absolute value of a single leukocyte subtype caused by infection or dehydration. Evidence from observational studies has demonstrated a significant association between these inflammation indices and the incidence and severity of many cardiovascular diseases, such as heart failure, myocardial infarction, and hypertension [ 10 ]. However, to date, no studies have investigated the predictive value of inflammation indices for LAT in VAF patients.…”

Section: Introductionmentioning

confidence: 99%

Association of inflammation indices with left atrial thrombus in patients with valvular atrial fibrillation

Zhou

Song

et al. 2023

BMC Cardiovasc Disord

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Background Inflammation has been implicated in the progressive exacerbation of valvular atrial fibrillation (VAF) and thrombogenesis. This study aimed to analyze the association of systemic inflammation as measured by six indices with left atrial thrombus (LAT) in patients with VAF. Methods This comparative cross-sectional analytical study included 434 patients with VAF. Logistic regression analysis was used to assess the predictive value of LAT using six inflammation indices: neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio (MLR), white blood cell-to-mean platelet volume ratio, neutrophil-to-mean platelet volume ratio, systemic immune inflammation index, and systemic inflammation response index. Receiver operating characteristic curves were plotted, and the area under these curves (AUC) were calculated to evaluate the discriminative ability of the indices. Results Transesophageal echocardiography revealed LAT in 143 (32.9%) patients. All six indices reflected a positive correlation with C-reactive protein levels. Multivariate logistic analysis revealed that these indices were independent predictors of LAT, and MLR appeared to perform best (odds ratio 12.006 [95% confidence interval (CI) 3.404–42.347]; P < 0.001; AUC 0.639 [95% CI 0.583–0.694]; P < 0.001). Conclusions Selected inflammatory indices were significantly and independently associated with LAT among patients with VAF.

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Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review

Cited by 24 publications

References 80 publications

The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study

The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study

The value of peripheral blood cell ratios in primary membranous nephropathy

Association of inflammation indices with left atrial thrombus in patients with valvular atrial fibrillation

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