Association of Neutrophil to Lymphocyte Ratio With Plaque Rupture in Acute Coronary Syndrome Patients With Only Intermediate Coronary Artery Lesions Assessed by Optical Coherence Tomography

Jiang, Jintong; Zeng, Huasu; Yang, Zhuo; Wang, Changqian; Gu, Jun; Zhang, Junfeng; Zhang, Huili

doi:10.3389/fcvm.2022.770760

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…The possible mechanism of CBI caused by CEA is that NLR is related to the vulnerability of atherosclerotic plaque, that is, patients with increased NLR are more likely to have plaque rupture and microembolism. Multiple clinical studies have con rmed the correlation between NLR and atherosclerotic plaque vulnerability [23,24]. A retrospective study in China composed of 588 patients with acute ischemic stroke and 309 healthy controls free of carotid plaque showed that NLR is independent predictors of vulnerable carotid plaque in patients with acute ischemic stroke [25].…”

Section: Discussionmentioning

confidence: 99%

The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study

Han,

Lai,

Zhang

et al. 2024

Preprint

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Background Neutrophil to lymphocyte ratio (NLR) is a biomarker which is related with inflammation and atherosclerosis. Higher NLR is associated with vulnerability of carotid atherosclerotic plaques. Covert brain infarction (CBI) following carotid endarterectomy (CEA) indicates poor prognosis in cognization. In this study, we aimed to investigate the relationship between NLR and CBI in patients who accepted CEA. Methods In this observational and retrospective cohort study, 333 patients who underwent CEA due to severe carotid artery stenosis were enrolled. NLR was acquired from routine blood tests upon admission. Postoperative CBI was detected on magnetic resonance imaging. Logistic regression analysis was used to examine the association between NLR and CBI. Results Patients with CBI had higher NLR (CBI patients: 2.45[1.76–3.58] vs non-CBI patients: 2.31[1.82–2.88]; P = 0.05). NLR is a strong independent factor predicting the risk of CBI following CEA (odds ratio [OR], 1.740; 95% confidence interval [CI]: 1.325–2.286; P < 0.001). Furthermore, the predictive risk value by NLR is not affected by other related factors. Conclusions NLR is associated with the risk of CBI in patients underwent CEA. NLR is a convenient and low-cost biomarker that can be used for risk stratification management of perioperative carotid stenosis patients.

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Section: Discussionmentioning

confidence: 99%

The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study

Han,

Lai,

Zhang

et al. 2024

Preprint

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“…22 Recent publications have demonstrated a link between elevated NLR and plaque rupture in coronary artery lesions assessed by optical coherence tomography in acute coronary syndrome. 23…”

Section: Characteristics Associated With Underlying Icadmentioning

confidence: 99%

Incidence, predictors, and impact on outcome of underlying intracranial atherosclerotic disease in acute vertebrobasilar artery occlusion undergoing endovascular therapy: Data from ANGEL-ACT registry

Sun

Tong

et al. 2023

International Journal of Stroke

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Background and Purpose: Intracranial atherosclerotic disease (ICAD) is a common etiology of acute vertebrobasilar artery occlusion (VBAO) in Asia, which complicated endovascular treatment (EVT). We aimed to investigate the incidence, impacts, and predictors of ICAD in VBAO. Methods: Subjects were selected from the ANGEL-ACT registry and divided into two groups based on whether underlying ICAD existed. Underlying ICAD was determined when the following situations arise in the occlusion site during EVT: 1) fixed stenosis degree >70% or 2) stenosis >50% with distal blood flow impairment or evidence of repeated reocclusion. Multivariable regression models were used to investigate the effect of underlying ICAD on outcomes measured by modified Rankin Scale (mRS) score at 90 days, and to identify baseline characteristics associated with underlying ICAD. Results: Among the 315 patients enrolled, 171 (54.3%) had underlying ICAD. Favorable functional outcomes (mRS 0-3) occurred in 79 of 163 patients (48.5%) with ICAD and 69 of 137 patients (50.4%) without ICAD (P=0.743). Outcomes were similar between the two groups and remained similar after adjusting for the confounders. History of hypertension and elevated admission neutrophil to lymphocyte ratio (NLR) were strong predictors of underlying ICAD, whereas history of atrial fibrillation and distal basilar artery occlusion were negative predictors. Conclusions: In our study, underlying ICAD was recognized in approximately half of the VBAO patients, leading to comparable outcomes after more complex EVT strategies. Some baseline characteristics were identified to be predictors for underlying ICAD, which were helpful to guide the EVT strategies before the procedure. Data access statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

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“…Lymphopenia indicates chronic inflammation and occurs secondary to the release of stress-related cortisol. An inverse relationship has been observed between lymphocyte counts and cardiac outcomes [12,13].…”

Section: Introductionmentioning

confidence: 99%

Clinical Utiliy of Serum Lactate Levels in Diabetic Ketoacidosis in Adult Patients Admitted to Emergency Department

Çetin¹,

Kilic²,

Yeşilaras³

et al. 2022

Ann Med Res

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Aim: To evaluate serum lactate and its clinical utility for disease severity among patients admitted to the emergency department with a diagnosis of diabetic ketoacidosis (DKA). Material and Methods: This is a retrospective data review that included patients ≥18 years of age and admitted to the department with a DKA diagnosis. Patients with a blood glucose level of ≥250 mg/dL between 01 January 2016 to 30 June 2021 with DKA were included. Patients without arterial blood gas or urine ketone analyses, or diagnosed with isolated hyperglycemia were excluded. DKA was defined as a blood glucose level ≥250 mg/dL, pH <7.3, HCO3 <18 mEq/L, and urine ketone positivity at admission. The DKA severity was graded based on the degree of metabolic acidosis based on pH and HCO3 levels. Results: A total of 230 patients were included (82 mild, 126 moderate, and 22 severe DKA). The median age was 44 years, and 50.4% of patients were males. Patient age (p=0.27), sex (p=0.63), and blood glucose levels (p=0.69) were similar between DKA groups. But, DKA severity was moderately and negatively correlated with pH (r=-0.44, p<0.001), weakly and negatively correlated with HCO3 (r=-0.25, p<0.001), and moderately and positively correlated with lactate (r=0.41, p<0.001). Conclusions: The primary outcome of this study was that serum lactate level is significantly correlated with DKA moderate, and monitoring the normalizing levels during treating the DKA may be utilized as a marker of efficiency in the emergency department.

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Association of Neutrophil to Lymphocyte Ratio With Plaque Rupture in Acute Coronary Syndrome Patients With Only Intermediate Coronary Artery Lesions Assessed by Optical Coherence Tomography

Cited by 7 publications

References 30 publications

The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study

The association between neutrophil to lymphocyte ratio and covert brain infarction after carotid endarterectomy: a single center retrospective study

Incidence, predictors, and impact on outcome of underlying intracranial atherosclerotic disease in acute vertebrobasilar artery occlusion undergoing endovascular therapy: Data from ANGEL-ACT registry

Clinical Utiliy of Serum Lactate Levels in Diabetic Ketoacidosis in Adult Patients Admitted to Emergency Department

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