Prognostic Usefulness of Serum Uric Acid After Acute Myocardial Infarction (The Japanese Acute Coronary Syndrome Study)

Kojima, Sunao; Sakamoto, Tomohiro; Ishihara, Masaharu; Kimura, Kazuo; Miyazaki, Shunichi; Yamagishi, Masakazu; Tei, Chuwa; Hiraoka, Hisatoyo; Sonoda, Masahiro; Tsuchihashi, Kazufumi; Shimoyama, Nobuo; Honda, Takashi; Ogata, Yasuhiro; Matsui, Kunihiko; Ogawa, Hisao

doi:10.1016/j.amjcard.2005.04.007

Cited by 154 publications

(165 citation statements)

References 15 publications

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“…COPD chronic obstructive pulmonary disease, ACE angiotensin converting enzyme, ARB angiotensin receptor blockers, PCI percutaneous coronary intervention, MI myocardial infarction, GFR glomerular filtration rate, AMI acute myocardial infarction, LN left main coronary artery, CABG coronary artery bypass graft, EF ejection fraction Intern Emerg Med after AMI, Kojima et al [13] find that the total mortality rate of patients whose serum UA concentrations are in the highest quartile is about 3.7 times higher than in those whose UA concentrations are in the lowest quartile. In their retrospective study (the Japanese Acute Coronary Syndrome Study), the Authors conclude that serum UA is a Comparisons have been performed with v 2 or Fisher's exact test for categorical variables and with Kruskal-Wallis (between tertiles of uric acid) and Mann-Whitney U (between gender) for continuous variables BMI body mass index, GFR glomerular filtration rate, AMI acute myocardial infarction, EF ejection fraction, PCI percutaneous coronary intervention, HbA1c glycosilated hemoglobin, Tn I troponin I, NT-proBNP N terminal-pro brain natriuretic peptide, ESR erythrocyte sedimentation rate, CRP C-reactive protein, HDL high density lipoprotein, LDL low-density lipoprotein Intern Emerg Med suitable marker for predicting AMI-related future.…”

Section: Discussionmentioning

confidence: 99%

“…Less is known about UA as a potential prognosticrisk factor for outcomes in patients affected specifically by acute myocardial infarction [11][12][13][14][15], and several studies suggest that a higher UA is independently associated with poorer survival in these patients. However, studies on this topic differ in number size, time of UA measurement (early phase vs within the first 48 h), and type of reperfusion [thrombolysis vs. percutaneous coronary intervention (PCI)].…”

Section: Introductionmentioning

confidence: 99%

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Uric acid in the early risk stratification of ST-elevation myocardial infarction

et al. 2011

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Controversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary percutaneous coronary intervention (PCI) whether uric acid (UA) levels are associated with in-hospital mortality and complications. Killip classes III--IV were more frequent in the 3°UA tertile that was associated with the highest values of peak Tn I (p = 0.005), NT-proBNP (p \ 0.001), and fibrinogen (p = 0.036). Uric acid was associated with mortality (crude OR: 1.24; 95% CI 1.03-1.51; p = 0.025), but, when adjusted for Tn I and renal failure (as inferred by eGFR \60 ml/min/1.73 m 2 ), uric acid lost its statistical significance, while Tn I (100 pg/ml step OR: 1.002; 95% CI 1.000-1.003; p = 0.007) and renal failure (OR 9.16; 95% CI 3.60-23.32; p \ 0.001) were independent predictors for in-ICCU mortality. Uric acid remained as independent predictor for in-ICCU complications (1 mg/dl step OR: 1.11; 95% CI 1.01-1.21; p = 0.030) together with admission glycemia (1 g/dl step OR: 1.50; 95% CI 1.19-1.91; p \ 0.001) and renal failure (OR: 1.46; 95% CI 0.99-2.16; p \ 0.001). In STEMI patients submitted to PCI, increased uric acid levels identify a subgroup more prone to in-ICCU complications, probably because hyperuricemia stems from several complex mechanisms ranging from pre-existing risk factors to the degree of myocardial ischemia (as indicated by Killip class, ejection fraction) and to the acute metabolic response (as inferred by glucose levels). Hyperuricemia is not independently associated with early mortality when adjusted for renal function and the degree of myocardial damage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uric acid in the early risk stratification of ST-elevation myocardial infarction

et al. 2011

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“…[11] Hyperuricemia is recognized a good predictor of heart failure and death in patients after AMI. [12][13][14] Compared with such markers as brain natriuretic peptide and high-sensitivity C-reactive protein, which have been widely used in assessing the prognosis of AMI, [15,16] whether SUA could be an independent predictor of heart failure and death after myocardial infarction remains to be confi rmed by further studies.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid in patients with acute ST-elevation myocardial infarction

Chen

Qiao

et al. 2012

World Journal of Emergency Medicine

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“…Here was a relationship between Killip class on day of admission and serum uric acid level. [10] Another studies showed that serum uric acid level rises in cardiac failure. [11] In present study, statistically significant correlation found between the uric acid level in serum and (p=0.001) on day 3 in Killip class and patients for Killip class 3 and 4 had increased levels of uric acid as paralleled to patients of class 1 and 2.…”

Section: Effects Of High Uric Acidmentioning

confidence: 99%

Prevalence of Uric Acid in Patient with Acute Myocardial Infarction

Jaiswal¹,

Singh²,

Anand³

et al. 2018

AIMDR

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Background: The uric acid in serum (SUA) is significantly related with cardiovascular disease, it is proved by clinically. The increased level of uric acid in the serum lead to highly platelet reactivity mediating inflammation and stimulate of smooth muscle cell production which probably degrades acute thrombosis. Methods: The blood samples were collected and sent to biochemistry laboratory for estimation of uric acid. This study conducted in the Departments of Biochemistry, Dr. Ram Manohar Lohia Medical College Lucknow. Results: In this study 200 patients included with acute myocardial infarction. Among the 200 patients, 148 (74%) were male and 52 (26%) were female. Among the 25-70 Age group , most of people from 56-70 age group. Mean of uric acid level in male cases was 5.6 and female cases was 5.2 , male controls was 4.2 and female controls was 3.6. Conclusion: The uric acid level in the serum are high in patients which had acute myocardial infarction as compare to other persons. It is also higher with the killips classes. The Killips classification and uric acid level in the serum is a good analyst of mortality after acute myocardial infarction, if is combined.

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Prognostic Usefulness of Serum Uric Acid After Acute Myocardial Infarction (The Japanese Acute Coronary Syndrome Study)

Cited by 154 publications

References 15 publications

Uric acid in the early risk stratification of ST-elevation myocardial infarction

Uric acid in the early risk stratification of ST-elevation myocardial infarction

Serum uric acid in patients with acute ST-elevation myocardial infarction

Prevalence of Uric Acid in Patient with Acute Myocardial Infarction

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